Keywords: VIGS; virus-induced gene silencing; TRV; tobacco rattle virus; PDS; phytoene desaturase; CRISPR; clustered regularly interspaced short palindromic repeats; LB; left border; RB; right border; RdRp; RNA-dependant RNA polymerase; MP; movement protein; 16K; 1
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Keywords: PET-RAFT; Lipase; RDRP; Protein-polymer hybrid; Grafting-from;
Keywords: SaV; Sapovirus; NSs; nonstructural proteins; GIII; genogroup III; RdRp; RNA-dependent RNA polymerase; ORF; open reading frame; UTR; untranslated region; nt; nucleotides; aa; amino acid; Sapovirus; Viral metagenomics; Genotype; Phylogenetic tree; Complete
Keywords: 2VP; 2-vinylpyridine; 4VP; 4-vinylpyridine; AA; acrylic acid; ATRP; atom transfer radical polymerization; CA; contact angle; CTAB; cetyltrimethylammonium bromide; CNT; carbon nanotubes; DA; decanoic acid; DCE; 1,2-dichloroethane; DEAEMA; 2-(diethylamino)e
Keywords: AFM; atomic force microscopy; AIBN; azobisisobutyronitrile; AN; acrylonitrile; ARGET; activators regenerated by electron transfer; ATRP; atom transfer radical polymerization; ATRA; atom transfer radical addition; BA; n-butyl acrylate; BIPE; bis(2-iodoprop
Keywords: 7DCMA; 7-deaza-2â²-C-methyladenosine; DENV; dengue virus; EV-A71; enterovirus A71; MTase; methyltransferase; NS5; non-structural protein 5; RAFI; rigid amphipathic fusion inhibitor; RdRp; RNA-dependent RNA polymerase; SAH; S-adenosyl-l-homocysteine; TBEV
Keywords: Heat shock protein 27; Sea perch; Nervous necrosis virus; Apoptosis; Interferon; HSP; heat shock protein; RGNNV; red spotted grouper nervous necrosis virus; IFN; interferon; Cyto; cytochrome c; APAF-1; apoptotic protease activating factor-1; Bcl-2; B-cell
Keywords: BYDV; Barley yellow dwarf virus; BWYV; Beet western yellows virus; CABYV; Cucurbit aphid-borne yellows virus; CYDV; Cereal yellow dwarf virus; DDA; data dependent analysis; ELISA; enzyme-linked immunosorbent assay; FDR; false discovery rate; LDV; Lactate
Keywords: AGET; activators generated by electron transfer; AIBN; azobisisobutyronitrile; ARGET; activators regenerated by electron transfer; ATRP; atom transfer radical polymerization; BDE; bond dissociation energy; BPMODA; bis(2-pyridylmethyl)octadecylamine; BPN;
Keywords: 5â²REN; 5â²-proximal replication enhancer element; AS; activator sequence; cPR; complementary promoter; Ct; C-terminal; CNV; cucumber necrosis virus; DI; defective interfering; DL; downstream linker; eEF1A; elongation factor 1A; ESCRT; endosomal sorting
Keywords: ASPV; Atlantic salmon paramyxovirus; CR; conserved region; CTD; C-terminal domain; FLDV; Fer-de-Lance virus; HeV; Hendra virus; HMPV; human metapneumovirus; L; large polymerase subunit; MeV; measles virus; MT; methyltransferase; MuV; mumps virus; N; nucle
Keywords: ARGET; activators regenerated by electron transfer; ATRP; atom transfer radical polymerization; CLD; chain length distribution; CFD; computational fluid dynamics; CRP; controlled radical polymerization (also known as RDRP); cmc; critical micelle concentra
Keywords: Microbial forensic methods; 454 sequencing; RT-qPCR; SYBR green; TSV; tobacco streak virus; SMV; soybean mosaic virus; BPMV; bean pod mottle virus; DIBA; dot-immunobinding assay; TRSV; tobacco ringspot virus; TomRSV; tomato ringspot virus; MP; movement pr
Keywords: CHIKV; chikungunya virus; SINV; Sindbis virus; SFV; Semliki Forest virus; Sur; suramin; nsP; nonstructural protein; RdRp; RNA-dependent RNA polymerase; RTCs; replication and transcription complexes; CPE; cytopathic effect; CC50; half maximal cytotoxic con
Keywords: ATRP; atom transfer radical polymerization; ARGET ATRP; activator regenerated by electron transfer ATRP; FRP; free radical polymerization; CLD; chain length distribution; CRP; controlled radical polymerization; ICAR ATRP; initiator for continuous activato
Keywords: SSR; simple sequence repeat; cSSR; compound simple sequence repeat; IMEx; imperfect microsatellite extraction; RD; relative density; RA; relative abundance; RDRP; RNA dependent RNA polymerase; TGB1-2-3; triple gene block 1-2-3; ORF; open reading frame; CP
Keywords: DAA; NS3/4A Protease Inhibitor; Nucleoside/Nucleotide; Non-nucleoside; DAA; direct-acting antiviral agent; DCV; daclatasvir; HCV; hepatitis C virus; HTA; host-targeted antiviral agent; IFN; interferon; ISG; interferon-stimulated gene; NI; nucleoside inhib
Keywords: HAstVs; human astroviruses; ORF; open reading frame; RdRp; RNA dependent RNA polymerase; DDSS; Diarrheal Disease Surveillance System; icddr,b; International Centre for Diarrhoeal Disease Research, Bangladesh; ELISA; enzyme-linked immunosorbent assay; RT-P
Keywords: DENV; dengue virus; WNV; West Nile virus; YFV; yellow fever virus; TBEV; tick-borne encephalitis virus; HCV; hepatitis C virus; WEEV; Western equine encephalitis virus; VSV; vesicular stomatitis virus; HBV; hepatitis B virus; HIV; human immunodeficiency v
High detection rate and genetic diversity of picobirnavirus in a sheep flock in Brazil
Keywords: Picobirnavirus; Sheep; RdRp; Genogroup I;
HSP70 Copurifies with Zika Virus Particles
Keywords: AHI; allosteric HSP70 inhibitor; DAA; direct acting antiviral; DGC; density-gradient centrifugation; HCV; hepatitis C virus; HSP; heat shock protein; MOI; multiplicity of infection; MTase; methyltransferase; NBD; nucleotide binding domain; NCR; non-coding
Genomic characterization of a RdRp-recombinat nebovirus strain with a novel VP1 genotype
Keywords: VP1; the major capsid protein; VP2; the minor capsid protein; RdRp; RNA-dependent RNA polymerase; nt; nucleotide; aa; amino acid; ORFs; open reading frames; UTR; untranslated region; Cattle disease; Novel nebovirus; Genome; RdRp recombination; VP1;
De novo assembly of honey bee RNA viral genomes by tapping into the innate insect antiviral response pathway
Keywords: SBV; Sacbrood virus; (+); positive-strand; (â); negative-strand; nt; nucleotide; RNAi; RNA interference; siRNA; small interfering RNA; vsiRNA; viral derived small interfering RNA; RdRp; RNA dependent RNA polymerase; VSD; Viral Surveillance and Diagnosis
High detection rates of picobirnaviruses in free roaming rats (Rattus spp.): Molecular characterization of complete gene segment-2
Keywords: Picobirnavirus; Rats (Rattus spp.); Complete gene segment-2; Caribbean region; 5â²untranslated region; 5â² UTR; Amino acid; aa; Nucleotide; nt; Picobirnaviruses; PBVs; RNA-dependent RNA polymerase; RdRp;
Pan-Genotype Hepatitis E Virus Replication in Stem Cell-Derived Hepatocellular Systems
Keywords: HLCs; Antiviral; Primary Isolates; Personalized Medicine; ALB; albumin; AFP; alpha-fetoprotein; bFGF; basic fibroblast growth factor; BM; basal medium; CsA; cyclosporine A; DE; definitive endoderm; DMSO; dimethyl sulfoxide; Dox; doxycycline; ESC; embryoni
Analysis of Reptarenavirus genomes indicates different selective forces acting on the S and L segments and recent expansion of common genotypes
Keywords: RdRp; RNA-dependent RNA polymerase; GPC; glycoprotein precursor; NP; nucleoprotein; GARD; Genetic Algorithm Recombination Detection; GTR; General Time Reversible; dN-dS; non-synonymous substitution-synonymous substitution rate; SLAC; single-likelihood anc
Tatanan A from the Acorus calamus L. root inhibited dengue virus proliferation and infections
Keywords: Acorus calamus l; Tatanan A; Dengue; DENV2 infection; CC; column chromatography; CC50; half maximal cytotoxicity concentration; CPE; cytopathic effect; DENV; dengue virus; DENV2; dengue virus type 2; DEPT; distortionless enhancement by polarization transf
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction
Keywords: Anti-Influenza; PA-PB1; RdRp; Amino acid coupling; SPPS; Diphenyl-pyridine; AcOEt; Ethyl acetate; CC50; Half maximal cytotoxic concentration; cRNA; complementar RNA; DCM; dichloromethane; DDQ; 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone; DIPEA; N,N-Diisopro
Chikungunya virus inhibition by peptidomimetic inhibitors targeting virus-specific cysteine protease
Keywords: Chikungunya virus; nsP2 protease; Protease inhibitor; FRET assay; Peptidomimetic compounds; Antiviral assay; CHIKV-Specific inhibitor; CHIKV; Chikungunya virus; CHIKF; Chikungunya fever; CHIKV nsP2pro; Chikungunya nsP2 protease; ORF; Open reading frame; M
Protein A from orange-spotted grouper nervous necrosis virus triggers type I interferon production in fish cell
Keywords: NNV; Protein A; IFN; Trigger; RdRp;
Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development
Keywords: AAF; IFN-α-activated factor; ATA; Aurintricarboxylic acid; BDV; border disease virus; BPgV; GBV-D; BVDV-1; bovine viral diarrhea virus-1; C; capsid protein; CLRs; C-type lectin receptors; Core; core protein; CSFV; classical swine fever virus; DENV; dengu
Old meets new: Combination of PLA and RDRP to obtain sophisticated macromolecular architectures
Keywords: AGET; activator generated by electron transfer; AlpGP; 1,2:3,4-Di-O-isopropylidene-6-O-acryloyl-α-d-galactopyranose; ATRP; atom-transfer radical polymerization; BEMP; 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine; BGMA; cis
Anti-TMV activity and functional mechanisms of two sesquiterpenoids isolated from Tithonia diversifolia
Keywords: TMV; Tobacco mosaic virus; ID-ELISA; Indirect enzyme-linked immunosorbent assay; CP; coat protein; RdRp; RNA-dependent RNA polymerase; qRT-PCR; Real-time fluorescence quantification; Curative activities; Sesquiterpene; Half-leaf method; Bio-pesticides;
Simple and effective generation of transgene-free induced pluripotent stem cells using an auto-erasable Sendai virus vector responding to microRNA-302
Keywords: SeV; Sendai virus; SeVdp; replication-defective and persistent Sendai virus; PSC; pluripotent stem cell; RdRp; RNA-dependent RNA polymerase; MEF; mouse embryonic fibroblast; UTR; untranslated region; Cluc; Cypridina noctiluca luciferase; LNA; locked nucle
Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors
Keywords: Flaviviridae; Virus; Polymerase; Analogue; Interrogating; Water; CMA; 2'-C-methyladenosine; CMA-TP; 2'-C-methyladenosine Triphosphate; CPUs; Computer-Processing Units; HCV; Hepatitis C Virus; JEV; Japanese Encephalitis Virus; NTP; Nucleoside Triphosphate;
Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200Â kV
Keywords: cryo-EM; cryo-electron microscopy; DED; direct electron detection; CCD; charge-coupled device; EM; electron microscopy; TEM; transmission electron microscope; dsRNA; double-stranded RNA; RdRp; RNA-dependent RNA polymerase; DQE; detective quantum efficienc
Molecular characterization and expression analysis of interferon-gamma in black seabream Acanthopagrus schlegelii
Keywords: Black seabream; IFN-gamma; Red spotted grouper nervous necrosis virus; JAK-STAT; ISG; AP-1; activator protein 1; bp; base pair; CaMKII; calcium/calmodulin kinase II; GAS; gamma IFN-activated sequences; ORF; open reading frame; GATA3; GATA-binding protein
Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities
Keywords: Chikungunya; RdRP; HDX-MS; Fluorescence anisotropy; Homology modelling;
Comparative transcriptomic analyses of male and female adult Toxocara canis
Keywords: ALG; apoptosis-linked gene; BTB; broad/complex/tramtrack/bric a brac; CCR4; C-C chemokine receptor type 4; CEH; carboxylesterase 1; CRN; cell death related nuclease; CSR; chromosome segregation protein; DPY; dumpy; EH; eclosion hormone; Elk-1; ets-like pr
Picornaviral polymerase structure, function, and fidelity modulation
Keywords: 3Dpol; picornavirus RNA-dependent RNA polymerase; CTP; cytosine triphosphate; CV; coxsackievirus B3; EC; polymerase-RNA elongation complex; EMCV; encephalomyocarditis virus; EV71; enterovirus 71; FMDV; foot-and-mouth disease virus; HCV; hepatitis C virus;
Cystoviral RNA-directed RNA polymerases: Regulation of RNA synthesis on multiple time and length scales
Keywords: ATP; adenosine triphosphate; BCS; binding-competent state; BOS; binding-occluded state; BVDV; bovine viral diarrhea virus; CTD; C-terminal domain; DdRP; DNA-directed RNA polymerase; DdDP; DNA-directed DNA polymerase; dsRNA; double-stranded RNA; DTD; dwell
A structural view of the RNA-dependent RNA polymerases from the Flavivirus genus
Keywords: BVDV; Bovine viral diarrhea virus; C; capsid; cHP; capsid region hairpin; DENV; Dengue virus; DB; dumbbell; E; envelope; EC; elongation complex; EV71; Enterovirus 71; HCV; Hepatitis C virus; HIV-1; Human immunodeficiency virus 1; IC; initiation complex; I
Structural analysis and insight into Zika virus NS5 mediated interferon inhibition
Keywords: ZIKV; Zika virus; NS5; non-structural protein 5; SIAH2; seven in absentia homolog 2; STAT2; Signal Transducer and Activator of Transcription 2; MTase; methyltransferase; IFN; interferon; IRF9; Interferon Regulatory Factor 9; ISGF3; Interferon-Stimulated G
Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design
Keywords: Phenyl [(phenylcarbamoyl)amino]benzene-1-sulfonate derivatives; N-Phenyl-[(phenylcarbamoyl)amino]benzene-1-sulfonamide derivatives; Fragment-linking strategy; Dengue virus; NS5 methyltransferase inhibitors; Antiviral activity; DENV; dengue virus; NS; non-
Research ArticleHepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity
Keywords: HEV; hepatitis E virus; RBV; ribavirin; ALT; alanine aminotransferase; IU; international units; γGT; γ-glutamyltransferase; CLL; chronic lymphoid leukemia; NGS; next-generation sequencing; RdRp; RNA-dependent RNA polymerase; HVR; hypervariable region; O
Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor
Keywords: Flavivirus; RNA dependent RNA polymerase; Crystal structure; Polymerase mutants; Non-competitive inhibition; Virus inhibition; RdRp; RNA dependent RNA polymerase; HeE1-2Tyr; N-{[8-(Cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazol-4-yl]carbo
Hepatitis E Virus Mutations: Functional and Clinical Relevance
Keywords: HEV; hepatitis E virus; ORF; open reading frame; MeT; methyltransferase; Y; Y-domain; PCP; papain-like cysteine protease; HVR; hypervariable region; X-domain; macro-domain; Hel; RNA helicase; RdRp; RNA-dependent RNA polymerase; PPR; polyproline region; CP
Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response
Keywords: IAV; influenza A virus; HO-1; heme oxygenase-1; Nrf2; erythroid 2-related factor 2; ISGs; IFN-stimulated genes; RdRp; RNA-dependent RNA polymerase; TLRs; toll-like receptors; RLR; RIG-I-like receptors; MKP5; MAPK phosphatase 5; IRF3; interferon regulatory
Discovery of HCV NS5B thumb site I inhibitors: Core-refining from benzimidazole to indole scaffold
Keywords: HCV; RdRp; Thumb site I; Indole; Anti-viral; Heterocycle; HCV; hepatitis C virus; RdRp; RNA-depended-RNA-polymerase; WHO; World Health Organization; HCC; hepatocellular carcinoma; SOC; standard of care; PEG-IFN-α; pegalated α-interferon; RVB; Ribavi
The dengue virus NS5 protein as a target for drug discovery
Keywords: DENV; dengue virus; DHF; dengue hemorrhagic fever; NS5; non-structural protein 5; MTase; methyltransferase; GTase; guanylyltransferase; RdRp; RNA-dependent RNA polymerase; NS3; non-structural protein 3; nt; nucleotide; ss; single strand; ds; double strand