Galactosilated dopamine increases attention without reducing activity in C57BL/6 mice
Keywords: پروتئین; Prodrug; Genetic models; ADHD
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PTD-modified ATTEMPTS system for enhanced asparaginase therapy: A proof-of-concept investigation
Keywords: پروتئین; ATTEMPTS approach; Asparaginase therapy; Prodrug; Targeting; Protein transduction domain (PTD) peptide
Chemical stability and bioadhesive properties of an ester prodrug of Δ9-tetrahydrocannabinol in poly(ethylene oxide) matrices: Effect of formulation additives
Keywords: پروتئین; Bioadhesion; THC; Poly(ethylene oxide); Stability; Prodrug; Antioxidants
Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs
Keywords: پروتئین; Nitric oxide; Prodrug; JS-K; Diazeniumdiolate; Cancer; GST
Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist
Keywords: پروتئین; Group II mGluRs; Antagonist; Fluorinated compound; Prodrug
Depsipeptide (FK228) inhibits growth of human prostate cancer cells
Keywords: پروتئین; FK228; Histone deacetylase inhibitor; Prostate-specific antigen; Prodrug; Lung metastasis; Prostate adenocarcinoma
Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC-1065 analog
Keywords: پروتئین; Prodrug; CC-1065; Albumin; Anticancer
Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol
Keywords: پروتئین; Prodrug; Ethyl dioxy phosphate; Acetaldehyde; Phosphatase; Formaldehyde
Preparation and evaluation of N3-O-toluyl-fluorouracil-loaded liposomes
Keywords: پروتئین; Liposomes; N3-O-toluyl-fluorouracil (TFu); Prodrug; Bioavailability
Oral colon targeted delivery systems for treatment of inflammatory bowel diseases: Synthesis, in vitro and in vivo assessment
Keywords: پروتئین; Synthesis; Colon; NSAIDs; Aspartic acid; Cyclodextrin; Prodrug; In vivo/in vitro
Peptide prodrugs: Improved oral absorption of lopinavir, a HIV protease inhibitor
Keywords: پروتئین; Lopinavir; LVR; VL; VVL; GVL; Peptide; Prodrug
Phenyl phosphotriester derivatives of AZT: Variations upon the SATE moiety
Keywords: پروتئین; Antiviral agents; Prodrug; Biotransformation
[18F]FBAU 3′,5′-dibenzoate, a lipophilic prodrug, enhances brain uptake of the cell proliferation tracer [18F]FBAU
Keywords: پروتئین; Proliferation marker; FBAU; Thymidine analogs; Brain uptake; Prodrug; PET
Incorporation of novel 1-alkylcarbonyloxymethyl prodrugs of 5-fluorouracil into poly(lactide-co-glycolide) nanoparticles
Keywords: پروتئین; Nanoparticle; Fluorouracil; Prodrug; Alkylcarbonyloxymethyl; Poly(lactide-co-glycolide)
Antitumoral activity of PEG–gemcitabine prodrugs targeted by folic acid
Keywords: پروتئین; Polymeric conjugates; PEGylation; Prodrug; Antitumor therapy; Active targeting
Influence of plasticizers on the stability and release of a prodrug of Δ9-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices
Keywords: پروتئین; THC; Plasticizers; Stability; Hot-melt; Poly (ethylene oxide); Release; Microenvironmental pH; Prodrug
Doxorubicin conjugated to d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS): Conjugation chemistry, characterization, in vitro and in vivo evaluation
Keywords: پروتئین; Cancer chemotherapy; Chemotherapeutic engineering; Drug modification; Prodrug; Polymer–drug conjugation
Galactosylated dopamine enters into the brain, blocks the mesocorticolimbic system and modulates activity and scanning time in Naples high excitability rats
Keywords: پروتئین; Naples rat lines; prodrug; behavior; HPLC; lectin histochemistry; ADHDADHD, attention deficit hyperactivity disorder; ANOVA, analysis of variance; BBB, blood–brain barrier; DA, dopamine; DAT, dopamine membrane transporter; GAL-DA, galactosylated form of d
Bisphosphonated fluoroquinolone esters as osteotropic prodrugs for the prevention of osteomyelitis
Keywords: پروتئین; Osteomyelitis; Fluoroquinolone; Bisphosphonates; Drug delivery; Prodrug
Structural Determinants of Glutathione Transferases with Azathioprine Activity Identified by DNA Shuffling of Alpha Class Members
Keywords: پروتئین; CDNB, 1-chloro-2,4-dinitrobenzene; GS, glutathionyl; GST, glutathione transferase; hA1, human GST A1-1; hA2, human GST A2-2; hA3, human GST A3-3; bA1, bovine GST A1-1; rA2, rat GST A2-2; rA3, rat GST A3-3directed evolution; drug resistance; prodrug; SAR
Commercially Available Prostaglandin Analogs for the Reduction of Intraocular Pressure: Similarities and Differences
Keywords: پروتئین; bimatoprost; glaucoma; intraocular pressure; latanoprost; ocular hypertension; prodrug; prostaglandin; prostaglandin ethanolamide; travoprost
Releasable PEGylation of proteins with customized linkers
Keywords: پروتئین; Reversible PEGylation; Customized PEG; Prodrug; Peptide; Protein therapeutics; Poly(ethylene glycol)
Overcoming steric effects in the coupling reaction of alkyloxycarbonyloxymethyl (AOCOM) halides with phenols: an efficient synthesis of AOCOM phenolic prodrugs
Keywords: پروتئین; Steric hindrance; Alkyloxycarbonyloxymethyl halide; Phenol; Prodrug;
Synthesis and biological evaluation of the suberoylanilide hydroxamic acid (SAHA) β-glucuronide and β-galactoside for application in selective prodrug chemotherapy
Keywords: پروتئین; Prodrug; Glucuronide; Galactoside; SAHA; HDAC; ADEPT
Synthesis and characterization of insulin-5-Fu conjugate, enabling insulin as multi-drug carrier via dendritic approach
Keywords: پروتئین; Insulin; 5-Fluorouracil; Prodrug; Characterization; Stability
Sulfenamides as prodrugs of NH-acidic compounds: A new prodrug option for the amide bond
Keywords: پروتئین; Prodrug; Sulfenamide; NH-acid; Amide; Bioavailability; Solubility; Dissolution rate; Permeability; Stability
Proinsecticide candidates N-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl derivatives of imidacloprid and 1-chlorothiazolylmethyl-2-nitroimino-imidazolidine
Keywords: پروتئین; Imidacloprid; Prodrug; N-(Oxodioxolyl)methyl derivative; Patch–clamp electrophysiology
Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir
Keywords: پروتئین; Prodrug; cHPMPC; HPMPC; Biotransformation; HCMV; Anti-viral; Biodefense
Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles
Keywords: پروتئین; Oxindole; Angiogenesis; Prodrug; Bioreduction
Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor
Keywords: پروتئین; Histone deacetylase inhibitor; Antiproliferative agent; Prodrug
Cyclic monophosphate prodrugs of base-modified 2′-C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication
Keywords: پروتئین; Antiviral; HCV; Nucleoside; Phosphorylation; cMP; Prodrug
Enhanced efficacy of 7-hydroxy-3-methoxycadalene via glycosylation in in vivo xenograft study
Keywords: پروتئین; Cadalene; Glycosylation; Prodrug; Drug delivery; Anticancer;
Evaluation of therapeutic efficacy of capecitabine on human breast carcinoma tissues and cell lines in vitro
Keywords: پروتئین; Capecitabine; Monotherapy; Prodrug; Cytotoxic drugs; Apoptosis
Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors
Keywords: پروتئین; Histone deacetylase inhibitor; Selective anticancer activity; Folate conjugate; Prodrug
Design and synthesis of novel prodrugs of 2′-deoxy-2′-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues
Keywords: پروتئین; Tumor targeting; Prodrug; Antitumor; Cytotoxic agent
Novel prodrug approach to photodynamic therapy: Fmoc solid-phase synthesis of a cell permeable peptide incorporating 5-aminolaevulinic acid
Keywords: پروتئین; 5-Aminolaevulinic acid; Photodynamic therapy; Solid phase peptide synthesis; Prodrug; Cell-penetrating peptide
Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration
Keywords: پروتئین; Phosphonate; Prodrug; Bis[(para-methoxy)benzyl] phosphonate ester
Design and synthesis of novel bis(l-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity
Keywords: پروتئین; Adefovir; Anti-HBV nucleotide; Amino acid; Prodrug
Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist
Keywords: پروتئین; Prostacyclin; IP receptor agonist; N-Acylsulfonamide; N-Acylsulfonylurea; Prodrug
Proline prodrug of melphalan, prophalan-l, demonstrates high therapeutic index in a murine melanoma model
Keywords: پروتئین; Prodrug; Melphalan; Mouse melanoma model; Prolidase; Therapeutic efficacy
Biological conversion of a water-soluble prodrug of cyclosporine A
Keywords: پروتئین; Cyclosporine A; Prodrug; Tears; Biotransformation; Enzymes; LC–MS; MS/MS
Tracking the dephosphorylation of resveratrol triphosphate in skin by confocal Raman microscopy
Keywords: پروتئین; Confocal Raman spectroscopy; Resveratrol; Permeation; Prodrug; Epidermis
Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug
Keywords: پروتئین; Diamidine; Diamidoxime; Prodrug; Trypanocidal agents; Human African trypanosomiasis; Trypanosoma brucei;
New MultiPEG-conjugated theophylline derivatives: Synthesis and pharmacological evaluations
Keywords: پروتئین; Conjugation; MultiPEG; Polymers; Prodrug
Hyaluronic Acid- Paclitaxel: Antitumor Efficacy against CD44(+) Human Ovarian Carcinoma Xenografts
Keywords: پروتئین; Hyaluronic acid; CD44; paclitaxel; prodrug; human ovarian carcinoma;
Synthesis and evaluation of water-soluble docetaxel prodrugs-docetaxel esters of malic acid
Keywords: پروتئین; Docetaxel; Prodrug; Malic acid; Water-soluble; Paclitaxel
LC–MS/MS method for simultaneous determination of viramidine and ribavirin levels in monkey red blood cells
Keywords: پروتئین; Ribavirin; Viramidine; Prodrug; Nucleoside; Nucleotide; Hepatitis C; LC–MS/MS
Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug
Keywords: پروتئین; Melatonin; Prodrug; POM; Pantetheine; Enzyme; Inhibition
Synthesis and epimerization of phenylalanyl 4-aminocyclophosphamides
Keywords: پروتئین; Cyclophosphamide; Prodrug; Proteolysis; Epimerization;
Identification of human reductases that activate the dinitrobenzamide mustard prodrug PR-104A: A role for NADPH:cytochrome P450 oxidoreductase under hypoxia
Keywords: پروتئین; Oxidoreductase; Reductive; Metabolism; Prodrug; Hypoxia; Cancer