Keywords: مهار کننده پروتئین کیناز; Drug-repurposing discovery; Protein kinase inhibitor; Lead optimization; Antifungal agrochemical;
مقالات ISI مهار کننده پروتئین کیناز (ترجمه نشده)
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Keywords: مهار کننده پروتئین کیناز; Protein kinase inhibitor; Dysgeusia; Dysosmia; Taste; Smell; Oral adverse events; Mucositis;
Binding assay for characterization of protein kinase inhibitors possessing sub-picomolar to sub-millimolar affinity
Keywords: مهار کننده پروتئین کیناز; Photoluminescence; Time-gated measurement; Control chart; Cheng-Prusoff equation; Protein kinase inhibitor; Affinity; ARC; conjugate of a heterocyclic fragment and a peptide (or a peptide analogue); ARC(Photo); ARC comprising a fluorescent dye, includes A
Keywords: مهار کننده پروتئین کیناز; ALK; anaplastic lymphoma kinase; ALL; acute lymphoblastic leukemia; CLL; chronic lymphocytic leukemia; CML; chronic myelogenous leukemia; CNS; central nervous system; CRC; colorectal cancer; DTC; differentiated thyroid carcinoma; DUSP; dual specificity ph
Keywords: مهار کننده پروتئین کیناز; Protein kinase inhibitor; Tyrosine kinase; Aurora-A kinase; Tumor growth factor (TGF); Cyclin dependent kinase (CDK); Antitubulin; QDLAYEUIKHXTLC-UHFFFAOYSA-N; PKDHDLKCEHQLFK-MOSHPQCFSA-N; HOIZWXRIWMVFPL-UHFFFAOYSA-N; DSDIWWSXOOXFSI-UHFFFAOYSA-N; DFJHSIWK
Safety and efficacy of the bumped kinase inhibitor BKI-1553 in pregnant sheep experimentally infected with Neospora caninum tachyzoites
Keywords: مهار کننده پروتئین کیناز; Neospora caninum; Sheep; Pregnancy; Treatment; Protein kinase inhibitor; BKI-1553;
Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors
Keywords: مهار کننده پروتئین کیناز; ALK; anaplastic lymphoma kinase; cMet; hepatocyte growth factor receptor; DIPEA; N,N-Diisopropylethylamine; DMF; N,N-Dimethylformamide; EML4; echinoderm microtubule-associated protein-like 4; FDA; food and drug administration; gk; gatekeeper; μW; micro w
A β-glucuronidase-responsive albumin-binding prodrug for potential selective kinase inhibitor-based cancer chemotherapy
Keywords: مهار کننده پروتئین کیناز; Cancer; Chemotherapy; Drug delivery; Self-immolative linker; β-Glucuronidase-responsive albumin-binding prodrug; Protein kinase inhibitor; Tumour microenvironment;
A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells
Keywords: مهار کننده پروتئین کیناز; GJ; Gap junction; Cx; Connexin; GJIC; GJ intercellular communication; PKA; cAMP-Dependent protein kinase; AKAP; A-kinase anchoring protein; AKB; A-kinase binding domain; ERM; Ezrin, radixin, moesin; hCG; Human chorion gonadotropin; ZO-1; Zonula occludens-
Characteristics, treatment patterns, and survival among ALK+ non-small cell lung cancer (NSCLC) patients treated with crizotinib: A chart review study
Keywords: مهار کننده پروتئین کیناز; Lung neoplasms; Carcinoma; Non-small-cell lung; Anaplastic lymphoma kinase; Protein kinase inhibitor; Survival;
Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology
Keywords: مهار کننده پروتئین کیناز; PKA; cyclic-AMP dependent protein kinase/protein kinase A; cAMP; 3â²,5â²-cyclic adenosine monophosphate; ATP; adenosine 5-triphosphate; C subunits; catalytic subunits; R subunits; regulatory subunits; AKAP; A-kinase anchoring protein; AGC group of kinas
Probing a 3,4â²-bis-guanidinium diaryl derivative as an allosteric inhibitor of the Ras pathway
Keywords: مهار کننده پروتئین کیناز; CRC; colorectal cancer; PK; protein kinase; PKI; protein kinase inhibitor; FDA; Federal Drug Agency; HL-60; acute myeloid leukaemia cell line; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; IC50; half maximal inhibitory concentration;
Phase 1 dose-escalation study of S-222611, an oral reversible dual tyrosine kinase inhibitor of EGFR and HER2, in patients with solid tumours
Keywords: مهار کننده پروتئین کیناز; Protein kinase inhibitor; Phase 1 clinical trial; EGFR; HER2; HER4;
Proteomics perturbations promoted by the protein kinase CK2 inhibitor quinalizarin
Keywords: مهار کننده پروتئین کیناز; CK2; Quinalizarin; Casein kinase 2; Protein kinase inhibitor; Phosphoproteome; Proteasome
Matrix effects in nilotinib formulations with pH-responsive polymer produced by carbon dioxide-mediated precipitation
Keywords: مهار کننده پروتئین کیناز; Nilotinib (PubChem CID: 644241); HPMC (PubChem CID: 57503849); Phthalic acid (PubChem CID: 1017); Amorphous; Dissolution; Nilotinib; Protein kinase inhibitor; pH sensitive polymer; UV imaging;
Quantitative analysis of a phosphoproteome readily altered by the protein kinase CK2 inhibitor quinalizarin in HEK-293T cells
Keywords: مهار کننده پروتئین کیناز; CK2; Quinalizarin; casein kinase 2; Protein kinase inhibitor; Phosphoproteome; Apoptosis;
Novel pyrrole carboxamide inhibitors of JAK2 as potential treatment of myeloproliferative disorders
Keywords: مهار کننده پروتئین کیناز; JAK2; Myeloproliferative disorders; Protein kinase inhibitor; Tumour cell proliferation inhibition; Anti-cancer agents;
Design of the INPULSIS⢠trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis
Keywords: مهار کننده پروتئین کیناز; Clinical trial; Phase III; Drug therapy; Protein kinase inhibitor; Protein tyrosine kinases;
Getting Syk: spleen tyrosine kinase as a therapeutic target
Keywords: مهار کننده پروتئین کیناز; protein kinase inhibitor; tyrosine phosphorylation; fostamatinib; allergic asthma; rheumatoid arthritis; leukemia
The phosphoinositide-dependent protein kinase 1 inhibitor, UCN-01, induces fragmentation: Possible role of metalloproteinases
Keywords: مهار کننده پروتئین کیناز; PDK1, phosphoinositide-dependent protein kinase 1; PTEN, phosphatase and tensin homologUCN-01; PDK1; Protein kinase; Protein kinase inhibitor; Protein fragmentationUCN-01, (7-hydroxystaurosporine (3R*,8S*, 9R*, 10R*,12R*)-2,3,9,10,11,12-hexahydro-3-hydrox
NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII
Keywords: مهار کننده پروتئین کیناز; NOX2; NADPH oxidase 2; gp91phox; catalytic subunit of NOX2; Ang II; Angiotensin II; ROS; Reactive oxygen species; H89; N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide; SERCA; SR Ca ATPAse; SR; sarcoplasmic reticulum; AIP; autoca
Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors
Keywords: مهار کننده پروتئین کیناز; JAK2; Myeloproliferative disorders; Protein kinase inhibitor; Tumour cell proliferation inhibition; Anti-cancer agents
Endothelial dysfunction and systemic hypertension by selective cGMP-dependent protein kinase I inhibition using novel cell-penetrating peptide delivered in vivo
Keywords: مهار کننده پروتئین کیناز; Nitric oxide; Protein kinase inhibitor; Endothelial dysfunction; Hypertension;
Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors
Keywords: مهار کننده پروتئین کیناز; PI3K/Akt/mTor inhibitor; Protein kinase inhibitor; Anti-cancer drugs;
Chemical proteomics and functional proteomics strategies for protein kinase inhibitor validation and protein kinase substrate identification: Applications to protein kinase CK2
Keywords: مهار کننده پروتئین کیناز; CK2; Protein kinase inhibitor; TBB; Chemoproteomics; Functional proteomics; Inhibitor profiling
Potential of protein kinase inhibitors for treating herpesvirus-associated disease
Keywords: مهار کننده پروتئین کیناز; herpesvirus; protein kinase; phosphorylation; protein kinase inhibitor; antiviral drug development
Roles of Apicomplexan protein kinases at each life cycle stage
Keywords: مهار کننده پروتئین کیناز; Apicomplexan protein kinase; Life cycle; Plasmodium; Protein kinase inhibitor; Toxoplasma;
Site-directed mutagenesis of the glycine-rich loop of death associated protein kinase (DAPK) identifies it as a key structure for catalytic activity
Keywords: مهار کننده پروتئین کیناز; Death associated protein kinase; Calmodulin; Glycine-rich region; Neurodegeneration; Central nervous system; Phosphorylation; Protein kinase inhibitor;
Identification of LY83583 as a specific inhibitor of Candida albicans MPS1 protein kinase
Keywords: مهار کننده پروتئین کیناز; LY83583; 6-anilino-5,8-quinolinedione; MBP; myelin basic protein; ODQ; 1H-[1,2,4]oxidiazolo[4,3-a]-quinoxaline-1-one; Protein kinase inhibitor; Monopolar spindle 1; Antifungal agent; Selective toxicity; Docking model; Guanylate cyclase inhibitor;
Gene transport and expression by arginine-rich cell-penetrating peptides in Paramecium
Keywords: مهار کننده پروتئین کیناز; CPP; cell-penetrating peptide; Cy3; Cyanine 3; FITC; fluorescein isothiocyanate; GFP; green fluorescent protein; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diohenyltetrazolium bromide; N/P; nitrogen (NH3+)/phosphate (PO4â); PKI; protein kinase inhibitor; PTD
Progesterone synthesis by human placental mitochondria is sensitive to PKA inhibition by H89
Keywords: مهار کننده پروتئین کیناز; AKAPs; anchoring kinase cAMP proteins; BSA; bovine serum albumin; DMPK; myotonin protein kinase; KCN; potassium cyanide; PCP; pentachlorophenol; PDVF; poly (vinylidene difluoride); PKA; protein kinase cAMP dependent; PKC; protein kinase C; PKI; protein ki
NMDA and AMPA receptors contribute to the maintenance of substance P-induced thermal hyperalgesia
Keywords: مهار کننده پروتئین کیناز; SP; NMDA; AMPA; Thermal hyperalgesia; Scratching behavior; Protein kinase inhibitor;
Combining Src inhibitors and aromatase inhibitors: A novel strategy for overcoming endocrine resistance and bone loss
Keywords: مهار کننده پروتئین کیناز; Src kinases; Aromatase inhibitor; Protein kinase inhibitor; Breast cancer; Bone resorption; Metastasis
Kinase inhibition-related adverse events predicted from in vitro kinome and clinical trial data
Keywords: مهار کننده پروتئین کیناز; PKI; protein kinase inhibitor; KT; kinase target; AE; adverse event; Kd; dissociation constant; Adverse event; Toxicity; Kinome; Kinase inhibitor; Computational modeling; Translational bioinformatics;
Synthesis of C-linked immobilized analogs of aloisine A by 'click' chemistry
Keywords: مهار کننده پروتئین کیناز; Protein kinase inhibitor; Immobilization; [3+2] Cycloaddition; Affinity chromatography; Structure-activity relationship studies;
Expression and purification of isotopically labeled peptide inhibitors and substrates of cAMP-dependant protein kinase A for NMR analysis
Keywords: مهار کننده پروتئین کیناز; Protein kinase A; Phospholamban; Protein kinase inhibitor; Recombinant peptides; Solution NMR; Isotopic labeling;
Inhibition of pro-inflammatory cytokine production by the dual p38/JNK2 inhibitor BIRB796 correlates with the inhibition of p38 signaling
Keywords: مهار کننده پروتئین کیناز; p38; Protein kinase inhibitor; T-cells; Neutrophils; Monocytes; High-content imaging
Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers
Keywords: مهار کننده پروتئین کیناز; pMHC; peptide-major histocompatibility complex; TCR; T cell receptor; CTL; cytotoxic T lymphocyte; PBMC; peripheral blood mononuclear cell; PKI; protein kinase inhibitor; CMV; cytomegalovirus; EBV; Epstein-Barr virus; PPI; preproinsulin; T cell; Tetramer;
Identification of novel, selective and potent Chk2 inhibitors
Keywords: مهار کننده پروتئین کیناز; Protein kinase inhibitor; Chk2 inhibitor; Chk; Chk2; DNA damage
Enhanced selectivity for inhibition of analog-sensitive protein kinases through scaffold optimization
Keywords: مهار کننده پروتئین کیناز; Chemical genetics; Protein kinase inhibitor; Purine scaffold;
Selective downregulation of EGF receptor and downstream MAPK pathway in human cancer cell lines by active components partially purified from the seeds of Livistona chinensis R. Brown
Keywords: مهار کننده پروتئین کیناز; Livistona chinensis; Protein kinase inhibitor; Antitumor activity; EGFR; Cell cycle; Apoptosis
Use of pseudosubstrate affinity to measure active protein kinase A
Keywords: مهار کننده پروتئین کیناز; Protein kinase A; Kinase assay; Protein kinase inhibitor; H89
Regulation of FSH receptor, PKIβ, IL-6 and calcium mobilization: Possible mediators of differential action of FSH
Keywords: مهار کننده پروتئین کیناز; Sertoli cells; FSH receptor; IL-6; Protein kinase inhibitor; Calcium
Features and potentials of ATP-site directed CK2 inhibitors
Keywords: مهار کننده پروتئین کیناز; CK2; casein kinase 2; Dyrk1A; dual specificity tyrosine phosphorylation-regulated kinase; DMAT; 4,5,6,7-tetrabromo-2-(dimethylamino)benzimidazole; GSK3; glycogen synthase kinase 3; HSP90; heat shock protein; MNX; 1,8-dihydroxy-4-nitro-xanthen-9-one; PI3 k
Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes
Keywords: مهار کننده پروتئین کیناز; AhR; aryl hydrocarbon receptor; Arnt; aryl hydrocarbon receptor nuclear translocator protein; CYP; cytochrome P450; cDNA; complementary DNA; DCFH-DA; 2,7-dichrolofluorescin diacetate; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Hsp; heat shock protei
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication
Keywords: مهار کننده پروتئین کیناز; Herpes simplex virus type 1; Interferon; SOCS3; Viral replication; Cell signal transduction; Protein kinase inhibitor; Jak3 inhibitor; STAT3;
Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia
Keywords: مهار کننده پروتئین کیناز; Bcr-Abl; Chronic myeloid leukaemia; Protein kinase inhibitor; Crystal structure; AMN107; BMS-354825; AZD0530;
Crystallography for protein kinase drug design: PKA and SRC case studies
Keywords: مهار کننده پروتئین کیناز; PKA; Protein kinase A; PIFtide; Phosphoinositide-dependent kinase 1 interacting fragment peptide; CDK2; cyclin-dependent kinase 2; ATP; adenosine triphosphate; PKB; Protein kinase B; PKC; Protein Kinase C; PKG; Protein kinase G; PKI; protein kinase A inhi