
Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor
Keywords: BRD4 inhibitor; Kinase; BI-2536; Dihydroquinoxalin-2(1H)-one; PLK1; Polo-like Kinase 1; JAK2; Janus kinase 2; PTMs; post-translational modifications; KAc; acetylated lysine; BET; Bromodomain and Extra-Terminal; P-TEFb; positive transcription elongation fa