Keywords: پورین نوکلئوزید فسفوریلا; ASD; autism spectrum disorders; CV; coefficient of variation; CV-ANOVA; cross-validation analysis of variance; ESI; electrospray ionization; GC-MS; gas chromatography coupled to mass spectrometry; 1H NMR and 1H-13C NMR; nuclear magnetic resonance of pro
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Keywords: پورین نوکلئوزید فسفوریلا; Flow cytometry; Intracellular protein; Monoclonal antibody; Primary immunodeficiency disease; Surface protein; ADA; adenosine deaminase; ALPS; autoimmune lymphoproliferative syndrome; APECED; autoimmune polyendocrinopathy-candidiasis-ectodermal dystrop
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; Dietary flavonoids; Inhibitory activity; Binding affinity; Molecular modeling;
Keywords: پورین نوکلئوزید فسفوریلا; PNP; purine nucleoside phosphorylase; H. pylori PNP-Zg; recombinant H. pylori PNP from clinical isolate of Clinical Hospital Center Zagreb, Croatia; XOX; xanthine oxidase; Ino; inosine; Ado; adenosine; m7Guo; 7-methylguanosine; SEC; size-exclusion chromat
Keywords: پورین نوکلئوزید فسفوریلا; 5-FC; 5-fluorocytosine; 5-FU; 5-fluorouracil; 6-MeP; 6-methylpruine; 6-MeP-dR; 6-methylpurine-2-deoxyriboside; 9-AC; 9-aminocamptothecin; 9-ACG; 9-aminocamptothecin glucuronide; ACV; acyclovir; ADEPT; antibody-directed enzyme prodrug therapy; API; active
Keywords: پورین نوکلئوزید فسفوریلا; Enzyme-coupled assay; Deoxynucleoside triphosphatase; Escherichia coli Dgt; Purine nucleoside phosphorylase; Xanthine oxidase; 8-Oxoguanine; NdpK; nucleoside diphosphate kinase; Dgt; deoxynucleoside triphosphohydrolase; UV; ultraviolet; FPBP; fluorescent
Keywords: پورین نوکلئوزید فسفوریلا; 6-Methylpurine; 2-Fluoroadenine; Purine nucleosides; Vorbrüggen glycosylation; Purine nucleoside phosphorylase; Cancer gene therapy;
Keywords: پورین نوکلئوزید فسفوریلا; Capillary electrophoresis; Adenosine deaminase; Purine nucleoside phosphorylase; Inhibitor screening; Red blood cells; Traditional Chinese medicinesADA, adenosine deaminase; PNP, purine nucleoside phosphorylase; RBC, red blood cell; SCID, severe combined
Keywords: پورین نوکلئوزید فسفوریلا; chronic hepatitis C; phosphorolysis; purine nucleoside phosphorylase; ribavirin; single nucleotide polymorphism; small intestine; TCONH2
Keywords: پورین نوکلئوزید فسفوریلا; Hypoxia; Ischemia/reperfusion; Purine nucleoside phosphorylase; Purine salvage; Xanthine oxidase
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; severe combined immunodeficiency; newborn screening; tandem mass spectrometry; late-onset; delayed-onset; purine nucleoside phosphorylase-combined immunodeficiency; T-cell receptor excision circle; inherited disorder; AC
A synergistic effect of phosphate, pH and Phe159 substitution on the formycin A association to the E. coli purine nucleoside phosphorylase
Keywords: پورین نوکلئوزید فسفوریلا; Absorption; Association; Emission; Formycin A; E.coli purine nucleoside phosphorylase (PNPWT); E.coli PNP mutants; Asp; aspartic acid; Arg; arginine; E; efficiency of FRET; f; fractional intensity; FA; formycin A; FAâ; formycin A anion; FRET; Fluorescen
Bioelectrocatalytic and electrochemical cascade for phosphate sensing with up to 6 electrons per analyte molecule
Keywords: پورین نوکلئوزید فسفوریلا; PNP; purine nucleoside phosphorylase; XOx; xanthine oxidase; GCE; glassy carbon electrode; P-Os; poly(1-vinylimidazole-co-allylamine)-[Os(bpy)2Cl]Cl; bpy; 2,2'-bipyridine; PEGDGE; poly(ethylene glycol) diglycidyl ether; Phosphate biosensing; Xanthine oxid
Assessing the role of deoD gene in Mycobacterium tuberculosis in vitro growth and macrophage infection
Keywords: پورین نوکلئوزید فسفوریلا; Mycobacterium tuberculosis; deoD gene; Purine nucleoside phosphorylase; Gene knockout;
Release of soluble and vesicular purine nucleoside phosphorylase from rat astrocytes and microglia induced by pro-inflammatory stimulation with extracellular ATP via P2X7 receptors
Keywords: پورین نوکلئوزید فسفوریلا; Brain cell cultures; Extracellular purine nucleoside phosphorylase (PNP); P2X7 receptor; Mechanism of release; Lysosomal vesicles; A-CM; astrocyte derived-conditioned medium; BME; Basal Medium Eagle; Bz-ATP; 3â²-O-benzoyl-benzoyl-ATP; CGNs; cerebellar gr
Effects of Nrf2 deficiency on arsenic metabolism in mice
Keywords: پورین نوکلئوزید فسفوریلا; ABC; ATP-binding cassette; AQP; aquaglyceroporin; ARE; antioxidant response element; CNC; Cap 'n' Collar; Cyt19; arsenic (III oxidation state) methyltransferase; GCL; glutamate-cysteine ligase; Gclc; glutamate-cysteine ligase catalytic subunit; Gc
6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase
Keywords: پورین نوکلئوزید فسفوریلا; 6-Methylpurine; 2-Fluoroadenine; Purine nucleoside phosphorylase; Prodrugs; Cancer gene therapy
Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice
Keywords: پورین نوکلئوزید فسفوریلا; A1; adenosine receptor type 1; A2A; adenosine receptor type 2A; A3; adenosine receptor type 3; ADP; adenosine diphosphate; AMP; adenosine monophosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AOPCP; É,β-methyleneadenosine 5â²-diph
Multiple disulfide bridges modulate conformational stability and flexibility in hyperthermophilic archaeal purine nucleoside phosphorylase
Keywords: پورین نوکلئوزید فسفوریلا; SsMTAPII; 5â²-deoxy-5â²-methylthioadenosine phosphorylase II from Sulfolobus solfataricus; PNP; purine nucleoside phosphorylase; AdoMet; S-adenosylmethionine; MTA; 5â²-deoxy-5â²-methylthioadenosine; PDI; protein-disulfide isomerase, DSC, differential
Regulation of NAD biosynthetic enzymes modulates NAD-sensing processes to shape mammalian cell physiology under varying biological cues
Keywords: پورین نوکلئوزید فسفوریلا; ADPR; ADP ribose; ARTs; ADP ribose transferases; ARTD1; poly-(ADP ribose) polymerase 1; NAADP; nicotinic acid adenine dinucleotide phosphate; CR; calorie restriction; PAR; poly-(ADP ribose); PGC-1; peroxisome proliferator-activated receptor-γ coactivator
Computer-aided identification of novel 3,5-substituted rhodanine derivatives with activity against Staphylococcus aureus DNA gyrase
Keywords: پورین نوکلئوزید فسفوریلا; PNP; purine nucleoside phosphorylase; MESG; 2-amino-6-mercapto-7-methylpurine ribose; GLIDE XP; grid-based ligand docking with energetics extra-precision; OPLS; optimized potentials for liquid simulations; SPC water; simple point charge water; NPT ensembl
AS3MT, GSTO, and PNP polymorphisms: Impact on arsenic methylation and implications for disease susceptibility
Keywords: پورین نوکلئوزید فسفوریلا; iAs-inorganic arsenic; MMA-monomethylated arsenic; DMA-dimethylated arsenic; AS3MT-arsenic (+3 oxidation state) methyltransferase; PNP-purine nucleoside phosphorylase; GSTO-glutathione-s-transferase omega; PMI-primary methylation index; SMI-
Original Full Length ArticleThe transition state analog inhibitor of Purine Nucleoside Phosphorylase (PNP) Immucillin-H arrests bone loss in rat periodontal disease models
Keywords: پورین نوکلئوزید فسفوریلا; PNP; Purine nucleoside phosphorylase; CEJ; Cemento-enamel junction; TRAP; Tartrate resistant acid phosphatase; RANKL; Receptor activator of NF-kB ligand; RANK; Receptor activator of NF-kB; CK; Cathepsin K; dGuo; Deoxyguanosine; LPS; Lipopolysaccharide; ME
Behavior of Plasmodium falciparum purine nucleoside phosphorylase in macromolecular crowded environment
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; Enzyme kinetics; Crowding agents; Fluorescence
Characterization and evaluation of Staphylococcus sp. strain LZ16 for the biological control of rice blast caused by Magnaporthe oryzae
Keywords: پورین نوکلئوزید فسفوریلا; Staphylococcus sp. strain LZ16; Antagonistic activity; Purine nucleoside phosphorylase; Rice blast
Capillary bioreactors based on human purine nucleoside phosphorylase: A new approach for ligands identification and characterization
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; Enzyme immobilization; Ligands screening; Immucillin analogues
Structure–activity relationship of a cold-adapted purine nucleoside phosphorylase by site-directed mutagenesis
Keywords: پورین نوکلئوزید فسفوریلا; Site-directed mutagenesis; Purine nucleoside phosphorylase; Protein structure homology modeling; Enzymatic synthesis; Ribavirin
Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: Palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides [1]
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; Organozinc halides; Cross-coupling reactions; 6-Alkyl; Cycloalkyl/aryl/heterocyclylpurine ribonucleosidesE. coli PNP, Escherichia coli purine nucleoside phosphorylase; MeP-dR, 9-(2-deoxy-β-d-ribofuranosyl)-6-methylpurine;
Role of disulfide bonds in conformational stability and folding of 5â²-deoxy-5â²-methylthioadenosine phosphorylase II from the hyperthermophilic archaeon Sulfolobus solfataricus
Keywords: پورین نوکلئوزید فسفوریلا; MTAP; 5â²-deoxy-5â²-methylthioadenosine phosphorylase; SsMTAPII; 5â²-deoxy-5â²-methylthioadenosine phosphorylase II from Sulfolobus solfataricus; PNP; purine nucleoside phosphorylase; MTA; 5â²-deoxy-5â²-methylthioadenosine; SDS-PAGE; sodium dodecyl
Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice
Keywords: پورین نوکلئوزید فسفوریلا; Cerebellum; Purine nucleoside phosphorylase; Purkinje cells
Trimeric purine nucleoside phosphorylase: Exploring postulated one-third-of-the-sites binding in the transition state
Keywords: پورین نوکلئوزید فسفوریلا; DFPP-DG; 9-(5â²,5â²-difluoro-5â²-phosphonopentyl)-9-deazaguanine; aza-DFPP-DG; 9-{[N-[3â³,3â³-difluoro-3â³-(diethylphosphono)propyl]amino]methyl}-9-deazaguanine; DFPP-G; 5â²,5â²-difluoro-5â²-phosphonopentyl)-9-guanine; (S)-PMP-DAP; 2,6-diamino-(S
The transferrin receptor and the targeted delivery of therapeutic agents against cancer
Keywords: پورین نوکلئوزید فسفوریلا; AD; adamantane; ADEPT; antibody-directed enzyme prodrug therapy; ADR; doxorubicin/adriamycin; Av; avidin; AVET; adenovirus-enhanced transferrinfection; ART; artemisinin; BAP; biotin-adaptor peptide; BBB; blood-brain barrier; BFU-E; blast forming unit-er
High-temperature cultivation and 5′ mRNA optimization are key factors for the efficient overexpression of thermostable Deinococcus geothermalis purine nucleoside phosphorylase in Escherichia coli
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; mRNA secondary structure; Recombinant protein expression; Deinococcus geothermalis; Thermostable protein
Effects of purine nucleoside phosphorylase deficiency on thymocyte development
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; thymocytes; apoptosis; proliferation; mice; immune deficiency; ADA; Adenosine deaminase; BrDU; 5-Bromo-2-deoxyuridine; dGK; Deoxyguanosine kinase; dGMP; Deoxyguanosine monophosphate; dGTP; Deoxyguanosine triphosphate; dGuo
Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; Mechanism of catalysis; X-ray diffraction; Conformational change; Active (binding) sites
Sensing purine nucleoside phosphorylase activity by using silver nanoparticles
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; Silver nanoparticle
Diagnostic d'un déficit immunitaire primitif de l'enfant
Keywords: پورین نوکلئوزید فسفوریلا; Déficit immunitaire; enfant; immunité humorale; immunité cellulaire; infections; Immune deficiency; childhood; humoral immunity; cellular immunity; infection; DI; déficit immunitaire; DICS; déficit immunitaire combiné sévère; DIC; déficit immunit
Crystal structure of Schistosoma purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor
Keywords: پورین نوکلئوزید فسفوریلا; Schistosomiasis; Purine nucleoside phosphorylase; Virtual screening; Crystal structure; Inhibitors
Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances
Keywords: پورین نوکلئوزید فسفوریلا; ADA; adenosine deaminase; 5BU; 5-Bromo uracil; AdR; deoxyadenosine; cdN; cytosolic 5â²-deoxynucleotidase; cNI; cytosolic 5â²-nucleotidase I; cNII; cytosolic 5â²-nucleotidase II; cpm; counts per minute; dCK; deoxycytidine kinase; dGK; deoxyguanosine kin
Crystal structure and molecular dynamics studies of human purine nucleoside phosphorylase complexed with 7-deazaguanine
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; 7-Deazaguanine; Molecular dynamics; Virtual screening; X-ray diffraction; Enzymatic assay;
Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase
Keywords: پورین نوکلئوزید فسفوریلا; Malaria; Purine nucleoside phosphorylase; Uridine phosphorylase; Transition state inhibitor; Drug discoveryADA, adenosine deaminase; BBB, 5-(m-benzyloxy)benzylbarbituric acid; BBBA, 1-[(2-hydroxyethoxy)methyl]-5-(m-benzyloxy)benzylbarbituric acid acyclonu
Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; 9-Deazaguanines; Phosphate mimic; Multi-substrate analogues inhibitors
Pediatric neurological syndromes and inborn errors of purine metabolism
Keywords: پورین نوکلئوزید فسفوریلا; Purine dismetabolisms; Neurological syndromes; Phosphoribosylpyrophosphate synthetase; Adenylosuccinate lyase; 5-Amino-4-imidazolecarboxamide ribotide transformylase/IMP cyclohydrolase; 5′-Nucleotidase; Adenosine deaminase; Purine nucleoside phosphorylase
Molecular and traditional chemotherapy: A united front against prostate cancer
Keywords: پورین نوکلئوزید فسفوریلا; Chemotherapy; Docetaxel; Molecular chemotherapy; Purine nucleoside phosphorylase; Gene directed pro-drug enzyme therapy; Conditionally replicating adenovirus;
EdU incorporation is an alternative non-radioactive assay to [3H]thymidine uptake for in vitro measurement of mice T-cell proliferations
Keywords: پورین نوکلئوزید فسفوریلا; EdU, 5-ethynyl-2′-deoxyuridine; BrdU, 5-bromo-2-deoxyuridine; PNP, purine nucleoside phosphorylase; PBMC, peripheral blood mononuclear cells; cpm, counts per minute5-ethynyl-2′-deoxyuridine; Thymidine; Purine nucleoside phosphorylase; T lymphocytes; Funct
Substrate specificity and kinetic mechanism of purine nucleoside phosphorylase from Mycobacterium tuberculosis
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; PNP; Substrate specificity; Initial velocity; Product inhibition; Fluorescence titration; pH-rate profiles; Solvent isotope effects; Pre-steady-state kinetics; Enzyme kinetic mechanism
Overexpression, purification and characterization of functional calf purine nucleoside phosphorylase (PNP)
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; Recombinant; Calf; Overexpression; Cloning
Effect of the phosphate substrate on drug-inhibitor binding to human purine nucleoside phosphorylase
Keywords: پورین نوکلئوزید فسفوریلا; Binding thermodynamics; Drug-inhibitors; Enzyme activity; Gel filtration; Isothermal titration calorimetry; Light scattering; Purine nucleoside phosphorylase
Molecular modeling and dynamics simulations of PNP from Streptococcus agalactiae
Keywords: پورین نوکلئوزید فسفوریلا; Purine nucleoside phosphorylase; Molecular modeling; Bioinformatics; Streptococcus agalactiae;
Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade
Keywords: پورین نوکلئوزید فسفوریلا; Purinergic signalling; Extracellular nucleotide release; Ecto-nucleotidase; Nucleotide kinase; Adenosine deaminase; Purine nucleoside phosphorylase