کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8539080 | 1561125 | 2017 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of Nrf2 deficiency on arsenic metabolism in mice
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کلمات کلیدی
MTRGSTM1PNPGCLGSRAQPGSSMRPscap ‘n’ collarKelch-like ECH associated protein 1NQO1GSTO1GCLCNuclear factor-E2-related factor 2GSTT1GCLMNAD(P)H:quinone oxidoreductase-1ABCCNCPRX1GSSGGSTA1SAMCyt19GPXγ-glutamylcysteine synthaseGSHγGCSHO1Nrf2keap1 - buy1ROS - ROSAquaglyceroporin - آگگلیسرپورینS-adenosylmethionine - اس-ادنوزیل متیونینantioxidant response element - عنصر پاسخ آنتی اکسیدانGlutamate–cysteine ligase - لیگاز Glutamate-CysteineArsenic metabolism - متابولیسم آرسنیکMethylenetetrahydrofolate reductase - متیلن تتراهیدروفولات ردوکتازARE - هستندheme oxygenase 1 - همای اکسیژناز 1Antioxidant response - پاسخ آنتی اکسیدانPeroxiredoxin 1 - پراکسیردوکسین 1Multidrug resistance proteins - پروتئین های مقاوم در برابر چندین رژیمPurine nucleoside phosphorylase - پورین نوکلئوزید فسفوریلاGlutamate–cysteine ligase catalytic subunit - کلوتامین کاتالیستی لیگاز گلوتامات-سیتئینATP-binding cassette - کیت اتصال به ATPGlutathione - گلوتاتیونoxidized glutathione - گلوتاتیون اکسید شدهglutathione reductase - گلوتاتیون ردوکتازglutathione synthetase - گلوتاتیون سنتتازglutathione peroxidase - گلوتاتیون پراکسیدازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Inorganic arsenic (iAs) is a known toxicant and carcinogen. Worldwide arsenic exposure has become a threat to human health. The severity of arsenic toxicity is strongly correlated with the speed of arsenic metabolism (methylation) and clearance. Furthermore, oxidative stress is recognized as a major mechanism for arsenic-induced toxicity. Nuclear factor-E2-related factor 2 (Nrf2), a key regulator in cellular adaptive antioxidant response, is clearly involved in alleviation of arsenic-induced oxidative damage. Multiple studies demonstrate that Nrf2 deficiency mice are more vulnerable to arsenic-induced intoxication. However, what effect Nrf2 deficiency might have on arsenic metabolism in mice is still unknown. In the present study, we measured the key enzymes involved in arsenic metabolism in Nrf2-WT and Nrf2-KO mice. Our results showed that basal transcript levels of glutathione S-transferase omega 2 (Gsto2) were significantly higher and GST mu 1 (Gstm1) lower in Nrf2-KO mice compared to Nrf2-WT control. Arsenic speciation and methylation rate in liver and urine was then studied in mice treated with 5Â mg/kg sodium arsenite for 12Â h. Although there were some alterations in arsenic metabolism enzymes between Nrf2-WT and Nrf2-KO mice, the Nrf2 deficiency had no significant effect on arsenic methylation. These results suggest that the Nrf2-KO mice are more sensitive to arsenic than Nrf2-WT mainly because of differences in adaptive antioxidant detoxification capacity rather than arsenic methylation capacity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 337, 15 December 2017, Pages 111-119
Journal: Toxicology and Applied Pharmacology - Volume 337, 15 December 2017, Pages 111-119
نویسندگان
Huihui Wang, Jiayu Zhu, Lu Li, Yongfang Li, Hang Lv, Yuanyuan Xu, Guifan Sun, Jingbo Pi,