Keywords: ریبونوکلئوتید ردوکتاز; Tf; transferrin; TfR; transferrin receptor; RR; ribonucleotide reductase; ROS; reactive oxygen species; MT; metallothionein; HO; heme oxygenase-1; Gallium; Iron; Cancer; Infections; Therapeutics; Metallodrugs;
مقالات ISI ریبونوکلئوتید ردوکتاز (ترجمه نشده)
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Keywords: ریبونوکلئوتید ردوکتاز; Thiosemicarbazones; Thiazolyl hydrazones; Ribonucleotide reductase; Arabinofuranosylcytosine; Human HL-60 promyelocytic leukemia cells; Synergistic combination effects;
Keywords: ریبونوکلئوتید ردوکتاز; Ribonucleotide reductase; Nucleotide metabolism; Inhibitors; Antiproliferative compounds; Cell cycle; Cytotoxicity; Oligomeric state; GEMMA;
Keywords: ریبونوکلئوتید ردوکتاز; Tf; transferrin; TfR; transferrin receptor; RR; ribonucleotide reductase; MT-2A; metallothionein-2A; HO-1; heme oxygenase-1; Gallium; Iron; Metallodrug therapeutics; Cancer; Infection; Ribonucleotide reductase;
Keywords: ریبونوکلئوتید ردوکتاز; Antitumor agents; Cancer; Chelators; Multidrug resistance; Schiff bases; ABC; ATP-binding cassette; APT; attached proton test; DMEM; dulbecco's modified eagle medium; HSAB; hard and soft acids and bases; MMP; matched molecular pair; MTT; 3-(4,5-dimethylth
Keywords: ریبونوکلئوتید ردوکتاز; 3-AP; 3-aminopyridine-2-carboxaldehyde thiosemicarbazone; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; AMP/ADP/ATP; adenosine mono-, di-, and tri-phosphate; BLM; Bloom syndrome RecQ helicase-like; BRAF; V-raf mu
Keywords: ریبونوکلئوتید ردوکتاز; ASK1; apoptosis signal-regulating kinase 1; ATF4; activating transcription factor 4; ATF6; activating transcription factor 6; Bcl-2; B-cell lymphoma 2; BiP; binding immunoglobulin protein; bZIP; basic leucine zipper; CDK; cyclin-dependent kinase; CDKI; CD
Integrating plant and animal biology for the search of novel DNA damage biomarkers
Keywords: ریبونوکلئوتید ردوکتاز; ARP; actin related protein; ASK; Arabidopsis SPK1-like; At; Arabidopsis thaliana; ATAF; arabidopsis transcription activation factor; ATM; ataxia telangiectasia mutated; ATR; ATM and Rad3-related; ATRIP; ATR-interacting protein; BARD; BRCA1-associated RING
Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic
Keywords: ریبونوکلئوتید ردوکتاز; Trx; thioredoxin; TrxR; thioredoxin reductase; Sec; selenocysteine; ROS; reactive oxygen species; RNR; ribonucleotide reductase; GSH; glutathione; GR; glutathione reductase; Grx; glutaredoxin; GPx; glutathione peroxidase; Msr; methionine-R-sulfoxide reduc
ZH-1 enhances the anticancer activity of gemcitabine via deoxyribonucleotide synthesis and apoptotic pathway against A549 cells
Keywords: ریبونوکلئوتید ردوکتاز; Gemcitabine; ZH-1; Apoptosis; Deoxyribonucleotides; Intrinsic apoptotic pathway; ATCC; American Type Culture Collection; ATP; adenosine-triphosphate; ATP13C15N; trioctylamine, 1,1,2-trichlorotrifluoroethane, stable isotope labeled adenosine-13C1015N5-trip
NADPH-dependent and -independent disulfide reductase systems
Keywords: ریبونوکلئوتید ردوکتاز; Ahp; alkyl hydroperoxide reductase; APS; 5'-adenylylsulfate; BSO; buthionine sulfoximine; CoA; coenzyme A; Cys; cysteine; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; FTR; ferredoxin-thioredoxin reductase; Gpx; glutathione peroxida
De novo transcriptome sequencing and comprehensive analysis of the heat stress response genes in the basidiomycetes fungus Ganoderma lucidum
Keywords: ریبونوکلئوتید ردوکتاز; G. lucidum; Ganoderma lucidum; HS; heat stress; cDNA; DNA complementary to RNA; DEGs; differential expressed genes; HSPs; heat shock proteins; HSFs; heat shock factors; oligo; oligodeoxyribonucleotide; GSH; glutathione; GST; glutathione S-transferase; CAT
Research PaperDidox (3,4-dihydroxybenzohydroxamic acid) suppresses IL-33-induced cytokine production in primary mouse mast cells
Keywords: ریبونوکلئوتید ردوکتاز; BMMC; bone marrow derived mast cell; HU; hydroxyurea; LPS; lipopolysaccharide; NAC; N-acetylcysteine; RNR; ribonucleotide reductase; Didox; IL-33; Mast cells; NFκB; AP-1; Allergic inflammation;
Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription
Keywords: ریبونوکلئوتید ردوکتاز; BMMC; bone marrow-derived mast cell; XL; cross-linking; IL; interleukin; RNR; ribonucleotide reductase; HU; hydroxyurea; NAC; N-acetylcysteine; Allergic inflammation; Mast cells; IgE; FcεRI, Didox; NFκB; AP-1;
Novel regulators and molecular mechanisms of p53R2 and its disease relevance
Keywords: ریبونوکلئوتید ردوکتاز; p53R2; Mitochondrial diseases; Cancer; Inflammation; Ribonucleotide reductase;
Differences in protein binding and excretion of Triapine and its Fe(III) complex
Keywords: ریبونوکلئوتید ردوکتاز; Drug development; Thiosemicarbazones; Triapine; Pharmacokinetics; In vivo; 5-HP; 5-hydroxypicolinaldehyde thiosemicarbazone; DMSO; dimethyl sulfoxide; dNTP; deoxynucleoside triphosphate; Dp44mT; di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone; EIC; e
Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage
Keywords: ریبونوکلئوتید ردوکتاز; ART; artemisinin; DCF; dichlorofluorescein; DCFH; 2â²,7â²-dichlorodihydrofluorescein; DHOD; dihydroorotate dehydrogenase; DNPH; dinitrophenylhydrazine; FP IX; ferritoprotoporphyrin IX; FTC; fluorescein 5-thiosemicarbazide; GR; glutathione reductase; Grx
Translation of Cardiac Myosin Activation With 2-Deoxy-ATP to Treat Heart Failure Via an Experimental Ribonucleotide Reductase-Based Gene Therapy
Keywords: ریبونوکلئوتید ردوکتاز; dATP; gene therapy; heart failure; myosin activation; ribonucleotide reductase; +dP/dt; maximum rate of pressure rise; âdP/dt; maximum rate of pressure decline; dATP; 2-deoxy-adenosine triphosphate; DCM; dilated cardiomyopathy; hESC-CM; human embryonic
Divergent assembly mechanisms of the manganese/iron cofactors in R2lox and R2c proteins
Keywords: ریبونوکلئوتید ردوکتاز; Ferritin; Di-metal carboxylate protein; Ribonucleotide reductase; EPR spectroscopy; Mössbauer spectroscopy; X-ray crystallography;
Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein
Keywords: ریبونوکلئوتید ردوکتاز; 3TC; lamivudine; cccDNA; covalently-closed-circular DNA; CI; combination index; CMC; Comprehensive Medicinal Chemistry; Gem; gemcitabine; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HU; hydroxyurea; NDPs; ribonucleoside diphosphates; dNDPs; deo
Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics
Keywords: ریبونوکلئوتید ردوکتاز; AC; adenylyl cyclase; AI; anemia of inflammation; cdks; cyclin-dependent kinases; bFGF; basic fibroblast growth factor; BpT; 2-benzoylpyridine thiosemicarbazone; Bp4eT; 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone; Bp44mT; 2-benzoylpyridine 4,4-dimethyl-
Necroptosis: The Trojan horse in cell autonomous antiviral host defense
Keywords: ریبونوکلئوتید ردوکتاز; Programmed necrosis; FADD; cFLIP; Serine/threonine protein kinase; Ribonucleotide reductase;
Ribonucleotide reductase is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells with dual resistant factors
Keywords: ریبونوکلئوتید ردوکتاز; Gemcitabine; Pancreatic cancer; Anticancer agent resistance; Nucleoside transporter; Ribonucleotide reductase
Research ArticleHepatitis B virus induces RNR-R2 expression via DNA damage response activation
Keywords: ریبونوکلئوتید ردوکتاز; HBV; hepatitis B virus; dNTPs; deoxyribonucleotide triphosphates; Chk1; checkpoint kinase 1; RNR; ribonucleotide reductase; DDR; DNA damage response; PHH; primary human hepatocytes; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; qRT-
2-Deoxy adenosine triphosphate improves contraction in human end-stage heart failure
Keywords: ریبونوکلئوتید ردوکتاز; ATP; adenosine triphosphate; dATP; 2-deoxy adenosine triphosphate; HMM; heavy meromyosin; LVAD; left ventricular assist device; R1R2; ribonucleotide reductase; RT50; time to 50% relaxation; RT90; time to 90% relaxation; SL; sarcomere length; Heart failure
dNTP deficiency induced by HU via inhibiting ribonucleotide reductase affects neural tube development
Keywords: ریبونوکلئوتید ردوکتاز; NTDs; neural tube defects; HU; hydroxyurea; RNR; ribonucleotide reductase; GD; gestation day; dNTP; deoxynucleoside triphosphate; HE; hematoxylin and eosin; SAM; S-adenosyl methionine; MTX; methotrexate; TS; thymidylate synthase; TUNEL; terminal deoxynucl
Epigallocatechin gallate, ellagic acid, and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic leukemia cells: Synergism with arabinofuranosylcytosine
Keywords: ریبونوکلئوتید ردوکتاز; Epigallocatechin gallate; Ellagic acid; Rosmarinic acid; Ribonucleotide reductase; Arabinofuranosylcytosine; HL-60 cells;
Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase
Keywords: ریبونوکلئوتید ردوکتاز; RNR; ribonucleotide reductase; GO; Gene Ontology; DDR; DNA damage response; DSB; double strand break; IP; immunoprecipitation; IR; ionizing radiation; MMS; methyl methanesulphonate; ROS; reactive oxygen species; dNTP; deoxyribonucleotide; STRING; Search T
Disruption of the mevalonate pathway induces dNTP depletion and DNA damage
Keywords: ریبونوکلئوتید ردوکتاز; ACN; acetonitrile; BrdU; 5-bromo-2â²-deoxyuridine; DMAPP; dimethylallyl diphosphate; dNs; deoxyribonucleosides; dNTP; deoxyribonucleoside triphosphate; E2F; E2 transcription factor; Fmev; 6-fluoromevalonate; IPP; isopentenyl diphosphate; HU; hydroxyurea;
Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies
Keywords: ریبونوکلئوتید ردوکتاز; Coumarins; Anticancer; Synthesis; Targets; SAR; IC50; ARI; aromatase inhibitor; CAM; choriallanotoic membrane; CDC; cell cycle division protein; CDK2; cyclin dependent kinase 2; CDKN1A; cyclin-dependent kinase inhibitor 1A; CYP; cytochromes P450; DDIT4; D
Akt and p53R2, partners that dictate the progression and invasiveness of cancer
Keywords: ریبونوکلئوتید ردوکتاز; Akt; P53R2; Ribonucleotide reductase; Cancer progression; Cell cycle;
The identification of novel 5â²-amino gemcitabine analogs as potent RRM1 inhibitors
Keywords: ریبونوکلئوتید ردوکتاز; Ribonucleotide reductase; Gemcitabine; CHK1; Deoxyribonucleotides; Oncology;
Compositional complexity of the mitochondrial proteome of a unicellular eukaryote (Acanthamoeba castellanii, supergroup Amoebozoa) rivals that of animals, fungi, and plants
Keywords: ریبونوکلئوتید ردوکتاز; BN-PAGE; blue native polyacrylamide gel electrophoresis; ERMES; ER-mitochondria encounter structure; ICL; isocitrate lyase; LC; liquid chromatography; ML; maximum likelihood; MRO; mitochondrion-related organelle; MalS; malate synthase; MEF; membrane-prote
Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in advanced-stage cervical and vaginal cancers
Keywords: ریبونوکلئوتید ردوکتاز; Triapine; Cervical cancer; Ribonucleotide reductase; Radiosensitization;
Trypanothione: A unique bis-glutathionyl derivative in trypanosomatids
Keywords: ریبونوکلئوتید ردوکتاز; 1-C-Grx; monothiol glutaredoxin; 2-C-Grx; dithiol glutaredoxin; CBS; cystathionine-β-synthase; CGL; cystathionine-γ-lyase; CHAP; cysteine histidine-dependent amidohydrolases/peptidases (protein domain); CS; cysteine synthase; DMPO; 5,5â²-dimethyl-l-pyr
Just getting into cells is not enough: Mechanisms underlying 4-(N)-stearoyl gemcitabine solid lipid nanoparticle's ability to overcome gemcitabine resistance caused by RRM1 overexpression
Keywords: ریبونوکلئوتید ردوکتاز; Ribonucleotide reductase; Endocytosis; Lysosome; Hydrolysis; Cell uptake; Cytarabine
Effect of substitution at N″-position of N′-hydroxy-N-amino guanidines on tumor cell growth
Keywords: ریبونوکلئوتید ردوکتاز; Hydroxyguanidine; Ribonucleotide reductase; Lead modification
A biologically relevant iron(III) phenoxyl radical complex: A thermodynamic investigation on the structure-radical stability relationship
Keywords: ریبونوکلئوتید ردوکتاز; Ribonucleotide reductase; Aminophenol; Model complex; Iron complexes
Novel mutator mutants of E. coli nrdAB ribonucleotide reductase: Insight into allosteric regulation and control of mutation rates
Keywords: ریبونوکلئوتید ردوکتاز; Ribonucleotide reductase; dNTP pools; DNA replication fidelity; Allosteric regulation;
Diverse interactions mediate asymmetric incompatibility by the het-6 supergene complex in Neurospora crassa
Keywords: ریبونوکلئوتید ردوکتاز; Nonallelic heterokaryon incompatibility; Ribonucleotide reductase; HET domain; Nonself recognition;
Short CommunicationIn silico analysis of DosR regulon proteins of Mycobacterium tuberculosis
Keywords: ریبونوکلئوتید ردوکتاز; HGT; Horizontal gene transfer; RNR; Ribonucleotide reductase; Usp; Universal stress protein; Mycobacterium tuberculosis; DosR regulon; In silico analysis; Niche adaptation; Hypoxia;
In vitro supplementation with deoxynucleoside monophosphates rescues mitochondrial DNA depletion
Keywords: ریبونوکلئوتید ردوکتاز; COX; cytochrome c oxidase; COX II; cytochrome c oxidase subunit II; DGUOK; deoxyguanosine kinase; dNMP; deoxy-nucleoside monophosphate; dNDP; deoxy-nucleoside diphosphate; dNTP; deoxy-nucleoside triphosphate; HIV; human immunodeficiency virus; HRP; horser
Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase
Keywords: ریبونوکلئوتید ردوکتاز; ASK1; apoptosis signal-regulated kinase-1; BSA; bovine serum albumin; BSO; buthionine sulfoximine; BUN; urea nitrogen; CDNB; 1-chloro-2,4-dinitrobenzene; Cr; creatinine; DTNB; 5,5â²-dithiobis (2-nitrobenzotic acid); GPx; glutathione peroxidase; GR; gluta
Electron hopping through proteins
Keywords: ریبونوکلئوتید ردوکتاز; Electron transfer; Multistep tunneling; Hopping maps; Redox proteins azurin; Ribonucleotide reductase; DNA photolyase; MauG
N-Hydroxy-N′-aminoguanidines as anti-cancer lead molecule: QSAR, synthesis and biological evaluation
Keywords: ریبونوکلئوتید ردوکتاز; QSAR; Pharmacophore modeling; N-Hydroxy-N′-aminoguanidines; N-Hydroxysemicarbazides; Ribonucleotide Reductase
Ribonucleotide reductase inhibition by p-alkoxyphenols studied by molecular docking and molecular dynamics simulations
Keywords: ریبونوکلئوتید ردوکتاز; p-Alkoxyphenol; Ribonucleotide reductase; Inhibitors of ribonucleotide reductase; Inhibitor binding site; Molecular dynamics simulation
Antiproliferative effects of some novel synthetic solanidine analogs on HL-60 human leukemia cells in vitro
Keywords: ریبونوکلئوتید ردوکتاز; Antiproliferative effect; Solanidine; Steroidal compound; Cell cycle arrest; Ribonucleotide reductase;
Radiosensitization of Human Cervical Cancer Cells by Inhibiting Ribonucleotide Reductase: Enhanced Radiation Response at Low-Dose Rates
Keywords: ریبونوکلئوتید ردوکتاز; Triapine; Cervical cancer; Ribonucleotide reductase; Radiosensitization;
Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation
Keywords: ریبونوکلئوتید ردوکتاز; Rrm1; muscle ribonucleotide reductase 1; Rrm2; muscle ribonucleotide reductase 2; ARC; adult rat cardiomyocyte; GFP; green fluorescent protein; RT50; RT90, time to 50% and 90% relaxation; DT50; DT90, time to 50% and 90% Ca2+ decay; Cardiomyocyte; Contract
A novel N-hydroxy-N′-aminoguanidine derivative inhibits ribonucleotide reductase activity: Effects in human HL-60 promyelocytic leukemia cells and synergism with arabinofuranosylcytosine (Ara-C)
Keywords: ریبونوکلئوتید ردوکتاز; N-hydroxy-N′-aminoguanidines; Ribonucleotide reductase; Cell cycle arrest; Arabinofuranosylcytosine; Synergistic combination effects