Keywords: داروی ایمنی; Hippocampal tissue slice; Extracellular recording; In vitro electrophysiology; Seizure liability; Preclinical animal species; Safety pharmacology;
مقالات ISI داروی ایمنی (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: داروی ایمنی; iPSC-CM cardiomyocytes; Cardiac safety; Safety pharmacology; SPS; Education; Strategy; Health authorities; FDA; Non-clinical models; In silico; In vitro; In vivo;
Keywords: داروی ایمنی; Safety pharmacology; Proarrhythmia; Torsades de pointes; Simulation;
Keywords: داروی ایمنی; modified pulsatilla granules; acute toxicity; subchronic toxicity; safety pharmacology;
Keywords: داروی ایمنی; Drug development; Drug discovery; Enzyme; Ion channel; Off-target; Receptor; Safety pharmacology; Side effect; Toxicology; Transporter;
Keywords: داروی ایمنی; Apneic event; Apnea; Intermittent hypoxia; ICHS7A; Sleep apnea; Safety pharmacology; Respiratory; Ventilatory instability; Drug safety;
Keywords: داروی ایمنی; Spray-dried dispersion; Amorphous solid dispersion; Safety pharmacology; Cardiovascular pharmacology; Telemetry; Hemodynamics
Keywords: داروی ایمنی; Safety pharmacology; EEG; Seizure; Sleep; Neurological functional observation battery; Abuse;
Keywords: داروی ایمنی; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; ANCOVA; analysis of covariance; ANOVA; analysis of variance; CDSER; Center for Drug Safety Evaluation and Research; CI; confidence interval; DSI; Data Sciences International;
Keywords: داروی ایمنی; Paracetamol; Overdose; Toxicity; Poisoning; Hepatotoxicity; Acute liver failure; Pharmacovigilance; Safety pharmacology;
Keywords: داروی ایمنی; α-GST; alpha-glutathione S-transferase; B2M; beta-2 microglobulin; BUN; blood urea nitrogen; CROs; contract research organisations; Cr; creatinine; CysC; cystatin C; DIKI; drug-induced kidney-injury; EFPIA; European Federation of Pharmaceutical Industrie
Keywords: داروی ایمنی; Regulatory; Methods; ICHS7A; Safety pharmacology; Respiratory; Nonclinical; PharmaPendiumâ¢;
Keywords: داروی ایمنی; Function; Methods; Nonclinical; Pulmonary; Respiratory; Safety Pharmacology;
Keywords: داروی ایمنی; KI, Konigsberg Instruments; CO, cardiac output; LVP, left ventricular pressure; HR, heart rate; AOP, aortic pressure; SVR, systemic vascular resistanceBlood flow; Cardiac output; Hydralazine; ICH S7A; Implants; Methods; Milrinone; Safety pharmacology; Sot
Keywords: داروی ایمنی; Safety pharmacology; S7A; S7B; QT; Telemetry; Cardiovascular; Respiratory; Central nervous system (CNS); Regulatory; Good laboratory practices (GLP);
Keywords: داروی ایمنی; Beagle dogs; Cynomolgus monkeys; Heart rate variability; Power spectral analysis; Safety pharmacology; Telemetry;
Keywords: داروی ایمنی; Two choice operant model; Animal model; Positive reinforcement; Salicylic acid; Drug side effect; Tinnitus; Safety pharmacology;
Keywords: داروی ایمنی; 3Rs; replacement, refinement and reduction of animals in research; ACSA; Agricultural Chemicals Safety Assessment; ADA; anti-drug antibody; CNS; central nervous system; DBS; dried blood spot; DART; developmental and reproductive toxicity; DRF; dose range
Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report
Keywords: داروی ایمنی; Safety pharmacology; Cardiotoxicity; Human-induced pluripotent stem cell-derived cardiomyocytes; Multi-electrode array technology; APD; action potential duration; APC; automated patch clamp; CiPA; Comprehensive in vitro Proarrhythmia Assay; CSRC; Cardiac
A new telemetry-based system for assessing cardiovascular function in group-housed large animals. Taking the 3Rs to a new level with the evaluation of remote measurement via cloud data transmission
Keywords: داروی ایمنی; Methods; Conscious dogs; Conscious minipig; Conscious non-human primate; Cardiovascular; ECG; Blood pressure; Telemetry; Stellar implants; TSE SYSTEMS; Safety pharmacology; Cloud data;
Do in vitro assays in rat primary neurons predict drug-induced seizure liability in humans?
Keywords: داروی ایمنی; Drug-induced seizures; MEA; Safety pharmacology; Primary neurons; in vitro; in vivo;
The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on IK1
Keywords: داروی ایمنی; iPSC-CMs; IK1; Safety pharmacology; Arrhythmia; CiPA; Cardiac electrophysiology;
Cross - site comparison of excitation-contraction coupling using impedance and field potential recordings in hiPSC cardiomyocytes
Keywords: داروی ایمنی; Arrhythmia; EAD; CardioExcyte 96; Cardiomyocytes; CiPA; Contractility; Extracellular field potential; hiPSC; Impedance; Safety pharmacology; AXG; Cor.4U®, hiPSC-CMs, Ncardia; BrCoV; Beat rate (beat period) coefficient of variation; CDI; iCell Cardiomyocy
Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception
Keywords: داروی ایمنی; Pharmacokinetics; Inflammation; Nociception; Safety pharmacology; IS01957; Para-coumaric acid derivative; p-CA; Para coumaric acid; ADME; Absorption, distribution, metabolism and excretion; CH; Chlorpromazine hydrochloride; PS; Pentobarbital sodium; PBS;
Evaluation of the PhysioTel⢠Digital M11 cardiovascular telemetry implant in socially housed cynomolgus monkeys up to 16 weeks after surgery
Keywords: داروی ایمنی; Cardiovascular safety; Cynomolgus monkeys; L-NAME; Methods; Minimal invasive; Moxifloxacin; Pathology; PhysioTel⢠Digital M11; Safety pharmacology; Telemetry implant;
Validation and utility of the PhysioTel⢠Digital M11 telemetry implant for cardiovascular data evaluation in cynomolgus monkeys and Beagle dogs
Keywords: داروی ایمنی; Telemetry; PhysioTel⢠Digital; M11; JET; Cardiovascular; Moxifloxacin; Doxazosin; Safety pharmacology; QTc prolongation;
CNS safety pharmacology: A focus on cognitive functions
Keywords: داروی ایمنی; Behavioral methods; Cognition; Diazepam; Haloperidol; MK-801; Nicotine; Scopolamine; Safety pharmacology; Rodents;
Safety pharmacology studies using EFP and impedance
Keywords: داروی ایمنی; CardioExcyte 96; Dofetilide; E4031; EAD-like; Extracellular field potential; Impedance; Isoproterenol; Nifedipine; Pentamidine; Safety pharmacology;
EEG in non-clinical drug safety assessments: Current and emerging considerations
Keywords: داروی ایمنی; EEG; Seizure; Polysomnography; Safety pharmacology; Convulsion; Neurotoxicity; Sleep; Spike; Telemetry;
The Diplomate in Safety Pharmacology (DSP) certification scheme
Keywords: داروی ایمنی; DSP; Diplomate in Safety Pharmacology; SP; safety pharmacology; SPS; Safety Pharmacology Society; JSPS; Japanese Safety Pharmacology Society; ICH; International Conference on Harmonization; SOT; Society of Toxicology; ACT; American College of Toxicology;
Assessment of seizure risk in pre-clinical studies: Strengths and limitations of the electroencephalogram (EEG)
Keywords: داروی ایمنی; Convulsions; EEG spectral analysis; Electromyography/EMG; Regulatory drug development; Safety pharmacology; Seizure; Sharp waves; Preclinical seizure risk assessment; Premonitory signs; Telemetry; Tremors; Video-EEG;
Therapeutic effect of Chinese patent medicine “Wuhuanghu” on porcine infectious pleuropneumonia and its acute and subchronic toxicity as well as evaluation of safety pharmacology
Keywords: داروی ایمنی; Chinese patent medicine “Wuhuanghu”; Porcine infectious pleuropneumonia; Anti-infection; Acute toxicity; Subchronic toxicity; Safety pharmacology
Acute and subchronic toxicity as well as evaluation of safety pharmacology of Galla chinensis solution
Keywords: داروی ایمنی; Galla chinensis; Acute toxicity; Subchronic toxicity; Safety pharmacology;
Evaluation of cardiovascular changes in dogs administered three positive controls using jacketed external telemetry-blood pressure (JET-BP)
Keywords: داروی ایمنی; Cardiovascular; Dogs; Electrocardiography; Methods; Nonclinical; Telemetry; Blood pressure; Power analysis; QT interval; Safety pharmacology;
14th Annual Meeting of the Safety Pharmacology Society: Threading through peripheral and central nervous system presentations
Keywords: داروی ایمنی; Aβ; Aβ-amyloid protein; AANEM; American Academy of Neuromuscular and Electrodiagnostic Medicine; AAN; American Academy of Neurology; AD; Alzheimer's Disease; API; Alzheimer's Prevention Initiative-APOE4; ADF; Abuse Deterrent Formulations; ADNI; Alzheime
hERG trafficking inhibition in drug-induced lethal cardiac arrhythmia
Keywords: داروی ایمنی; Acquired long QT syndrome; hERG channel; hERG trafficking inhibition; Safety pharmacology;
Reprint of “Non-invasive measure of respiratory mechanics and conventional respiratory parameters in conscious large animals by high frequency Airwave Oscillometry”
Keywords: داروی ایمنی; Airway resistance; Airwave Oscillometry; Dog; Methacholine; Monkey; Respiratory; Safety pharmacology;
Non-invasive measure of respiratory mechanics and conventional respiratory parameters in conscious large animals by high frequency Airwave Oscillometry
Keywords: داروی ایمنی; Airway resistance; Airwave Oscillometry; Dog; Methacholine; Monkey; Respiratory; Safety pharmacology
Original articleMeasurement of hyper- and hypotension during repeated dose toxicity studies in either freely moving or physically restrained cynomolgus monkeys
Keywords: داروی ایمنی; Cardiovascular; Hypertension; Hypotension; HDO; Cynomolgus monkey; JET; Telemetry; Method; Safety pharmacology; Hemodynamic;
Model-based analysis of thromboxane B2 and prostaglandin E2 as biomarkers in the safety evaluation of naproxen
Keywords: داروی ایمنی; Biomarkers; Safety pharmacology; Naproxen; PKPD modelling; Drug development; Long term safety;
Telemetry video-electroencephalography (EEG) in rats, dogs and non-human primates: Methods in follow-up safety pharmacology seizure liability assessments
Keywords: داروی ایمنی; Convulsions; EEG spectral analysis; Electromyography/EMG; Regulatory drug development; Safety pharmacology; Sedation; Seizure; Premonitory signs; Telemetry; Tremors;
Antisense oligonucleotides on neurobehavior, respiratory, and cardiovascular function, and hERG channel current studies
Keywords: داروی ایمنی; ASO; Antisense Oligonucleotide; CNS; Central Nervous System; ECG; Electrocardiography; FOB; Functional Observatory Battery; GLP; Good Laboratory Practice; hERG; Human Ether-a-go-go related gene; ICH; International Conference on Harmonisation; IC50; The ha
Dose-dependent antihypertensive determination and toxicological studies of tilianin isolated from Agastache mexicana
Keywords: داروی ایمنی; Agastache mexicana; Antihypertensive; Median effective dose; Median lethal dose; Safety pharmacology; Tilianin;
Hydroxypropyl-β-cyclodextrin impacts renal and systemic hemodynamics in the anesthetized dog
Keywords: داروی ایمنی; CD; cyclodextrin; CI; confidence interval; CO; cardiac output; CV; cardiovascular; DBP; diastolic blood pressure; FDA; Food and Drug Administration; GFR; glomerular filtration rate; GLP; Good Laboratory Practice; hERG; human ether-a-go-go related gene; HP
Simulation of early after-depolarisation in non-failing human ventricular myocytes: Can this help cardiac safety pharmacology?
Keywords: داروی ایمنی; early after-depolarisation; safety pharmacology; cardiac action potential simulation; ORd model; maximal effective free therapeutic plasma concentration
Best practice in the conduct of key nonclinical cardiovascular assessments in drug development: Current recommendations from the Safety Pharmacology Society
Keywords: داروی ایمنی; Dogs; Monkeys; Methods; Cardiovascular; QT Prolongation; Safety Pharmacology
Behavioral profiling of zebrafish embryos exposed to a panel of 60 water-soluble compounds
Keywords: داروی ایمنی; Zebrafish embryo; Behavior; Toxicology; Safety pharmacology; Predictive model; Drug discovery
Evaluation of a novel ECG lead placement method in telemetered freely moving cynomolgus monkeys: Assessment of an intravascular biopotential lead
Keywords: داروی ایمنی; Methods; Telemetry; Safety pharmacology; ECG; Cardiovascular; Surgery
Cardiovascular and respiratory safety pharmacology in Göttingen minipigs: Pharmacological characterization
Keywords: داروی ایمنی; Methods; Minipig; Cardiovascular; Respiratory; Telemetry; Safety pharmacology
Effects of K201 on repolarization and arrhythmogenesis in anesthetized chronic atrioventricular block dogs susceptible to dofetilide-induced torsade de pointes
Keywords: داروی ایمنی; K201; JTV519; Beat-to-beat variability of repolarization duration; Ventricular arrhythmia; Cardiac electrophysiology; Safety pharmacology