Keywords: خیر; Prostate; SHH; Stem cells; Epithelial-mesenchymal interaction; Stroma; Prostate cancer;
مقالات ISI خیر (ترجمه نشده)
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Keywords: خیر; Medulloblastoma; Adults; Treatment; SHH; WNT
Keywords: خیر; Glioblastoma; Treatment; Review; Pharmacology; Targeted therapy; Stem cell; AKT; protein kinase B; BBB; blood-brain barrier; BCNU; carmustin; CCNU; lomustin; c-MET; hepatocyte growth factor receptor; EGF(R); epidermal growth factor (receptor); EGFRvIII; e
Keywords: خیر; AA; ascorbic acid; ALS; amyotrophic lateral sclerosis; BDNF; brain derived neurotropic factor; BMP; bone morphogenetic protein; DNMT; DNA methyltransferase; EB; embryoid body; EBNA1; Epstein-Barr nuclear antigen-1; ERK; extracellular signal-regulated ki
Keywords: خیر; Ectoderm; Neural crest; Placodes; Cell specification; BMP; Wnt; FGF; Shh;
Keywords: خیر; Caffeine; Brain development; BDNF; Shh; Synaptic proteins
Keywords: خیر; NGF; nerve growth factor; DSB; double strand break; SSB; single strand break; ATR; ataxia telangiectasia and Rad3 related protein; ATM; ataxia telangiectasia mutated protein; Shh; sonic hedgehog; DPP; decapentaplegic; NPC; neuronal progenitor cell; PSM; p
Keywords: خیر; COX-2; cyclooxygenase-2; CTLs; Cytotoxic T Lymphocytes; DCs; dendritic cells; ECM; extracellular matrix; EGF; epidermal growth factor; FAK; focal adhesion kinase; FAP-α; fibroblast activation protein-α; FGF; fibroblast growth factor; HSCs; hepatic stell
Keywords: خیر; LPC; liver progenitor cell; Hh; Hedgehog; SHH; Sonic Hedgehog; IHH; Indian Hedgehog; DHH; Desert Hedgehog; PTCH1; Patched 1; SMO; Smoothened; GLI; GLI-Kruppel family of transcription factors; GLI-A; GLI full-length activator; Pc; primary cilia; TAA; thioa
Keywords: خیر; Ureter; CAKUT; Tbx18; Shh; Wnt; Bmp;
Keywords: خیر; GLI1/2/3; glioma-associated oncogene homologue 1/2/3; PTCH; patched; SMO; smoothened; SUFU; suppressor of fused; CDO; CAM-related/downregulated by oncogenes; BOC; brother of CDO; GAS1; growth arrest-specific 1; PKA; protein kinase A; GSK3β; glycogen synt
Keywords: خیر; Aβ; amyloid-β; AD; Alzheimer's disease; ALP; autophagy-lysosome pathway; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ApoER2; apolipoprotein E receptor 2; APP; Aβ precursor protein; BDNF; brain-derived neurotrophic factor; CSF; cere
Keywords: خیر; ACAT; acyl-CoA cholesterol acyltransferase; ACC; acetyl CoA carboxylases; ACLY; ATP citrate lyases; ACSL; acyl CoA synthetases long chain family; ADRP; adipose differentiation related protein; AGP; advanced glycation end products; AGPAT; acylglycerophosph
Keywords: خیر; Development; Gastric Epithelium; Signal Transduction; Tissue Regeneration; CCK-BR; cholecystokinin/gastrin-B receptor; ECL; enterochromaffin-like; GFP; green fluorescent protein; GKO; gastrin deficient; Gli1; glioma-associated oncogene homolog 1; Ihh; Ind
Keywords: خیر; BrdU; bromodeoxyuridine; Cdk; cyclin-dependent kinase; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified eagle medium; Myo7a; myosin VIIA; P2; postnatal day 2; Pax2; paired box 2; pRb; retinoblastoma protein; Ptc; patched; Rb1; retinoblas
Keywords: خیر; IPF; idiopathic pulmonary fibrosis; AEC; alveolar epithelial cell; TGF-β; transforming growth factor; CTGF; connective tissue growth factor; Shh; sonic hedgehog; PGE2; prostaglandin E2; ROS; reactive oxygen species; H2O2; hydrogen peroxide; Pulmonary fib
Keywords: خیر; ECM; extracellular matrix; EGL; external granular layer; GCP; granule cell precursors; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GFAP; glial fibrillary acidic protein; IGL; internal granular layer; ML; molecular layer; NeuN; neuronal nuclei; PL; Pu
Keywords: خیر; SHH; Intestinal atresia; Expression; Foxf1; Fgfr2IIIb−/−; Organ culture
The expression of Shh, Ptch1, and Gli1 in the developing caudal spinal cord of fetal rats with ARMs
Keywords: خیر; Lumbosacral spinal cord; Shh; Ptch1; Gli1; Anorectal malformations;
Strong sonic hedgehog signaling in the mouse ventral spinal cord is not required for oligodendrocyte precursor cell (OPC) generation but is necessary for correct timing of its generation
Keywords: خیر; Floor plate; Sonic hedgehog signaling; Embryonic spinal cord; Oligodendrocyte; Bromi; CNS; central nervous system; FP; floor plate; HSPG; heparan sulfate proteoglycan; NC; notochord; MN; motor neuron; OPC; oligodendrocyte precursor cell; Shh; sonic hedgeh
Wip1 regulates blood-brain barrier function and neuro-inflammation induced by lipopolysaccharide via the sonic hedgehog signaling signaling pathway
Keywords: خیر; BBB; blood brain barrier; TJ; tight junction; Wip1; wild-type p53-induced phosphatase 1; MAPK; p38 mitogen-activated protein kinase; ATM; ataxia-telangiectasia mutated; SHH; sonic hedgehog; LPS; lipopolysaccharide; hBMECs; human brain-microvascular endoth
Sinomenine reduces growth and metastasis of breast cancer cells and improves the survival of tumor-bearing mice through suppressing the SHh pathway
Keywords: خیر; Hh; Hedgehog; SMO; smoothened; Ptch1; Patched 1 receptor 1; SHh; sonic hedgehog; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B cells; EMT; epithelial-mesenchymal transition; qPCR; quantitative polymerase chain reaction; IHC; hematoxylin
Extractive from Hypericum ascyron L promotes serotonergic neuronal differentiation in vitro
Keywords: خیر; Cell differentiation; Chemical modification; Depression; Chinese medicine; Neural differentiation; Serotonergic neuron; ESCs; embryonic stem cells; 5-HT; 5-hydroxytryptamine; MPLC; medium pressure liquid chromatography; HPLC; high-performance liquid chrom
Emerging roles and mechanisms of FOXC2 in cancer
Keywords: خیر; FOXC2; Forkhead box protein C2; EMT; epithelial-mesenchymal transition; NSCLC; non-small cell lung cancer; EGFR; epidermal growth factor receptor; siRNA; small (or short) interfering RNA; MAPK; mitogen-activated protein kinase; PI3K; phosphatidylinosito
Skin and scale regeneration after mechanical damage in a teleost
Keywords: خیر; ECM; extracellular matrix; fn1a; fibronectin 1a; colIα1; collagen type I, alpha 1; colVα2; collagen type V, alpha 2; colXα1; collagen type X, alpha 1; ogn1; osteoglycin 1; ogn2; osteoglycin 2; crtac1a; cartilage acidic protein 1a; cyr61; cysteine-rich
Translating Developmental Principles to Generate Human Gastric Organoids
Keywords: خیر; Organoids; Pluripotent Stem Cells; Directed Differentiation; Endoderm; Gastric Development; BMP; bone morphogenetic protein; e; embryonic day; ECL; enterochromaffin-like; ENS; enteric nervous system; ENCC; enteric neural crest cell; GI; gastrointestinal;
Scutellaria: Debates on the anticancer property
Keywords: خیر; Bcl-2; B-cell lymphoma 2; 5-FU; 5-Fluorouracil; TGF-β1; transforming growth factor beta 1; PTEN; phosphatase and tensin homolog; HIF-1α; hypoxia-inducible factor 1-alpha; MAPK; mitogen-activated protein kinase; CRC; cyclic redundancy check; SHH; sonic h
TGF-β Signaling Regulates Development of Midbrain Dopaminergic and Hindbrain Serotonergic Neuron Subgroups
Keywords: خیر; 5-HT; 5-hydroxytryptamine; Aldh1a1; aldehyde dehydrogenase 1 family member A1; Cck; cholecystokinin; cKO; conditional knockout; DIV; day in vitro; DR; dorsal raphe; MR; median raphe; PMR; paramedian raphe; RM; raphe magnus; En1; engrailed 1; ES; embryonic
The Sonic Hedgehog signaling pathway regulates inferior alveolar nerve regeneration
Keywords: خیر; SC; Schwann cell; Shh; Sonic Hedgehog; Ptch1; patched 1; Smo; Smoothened; Gli; glioma-associated oncogene homolog; IAN; inferior alveolar nerve; GFP; green fluorescent protein; PGP9.5; protein gene product 9.5; FITC; fluoresceinisothiocyanate; MBP; myelin
Expression Undercurrents of Sonic Hedgehog in Colorectal and Pancreatic Cancers
Keywords: خیر; Colorectal cancer; CRC; Pancreatic cancer; PC; Sonic hedgehog; SHH; Indian hedgehog; IHH; Desert hedgehog; DHH; Bone morphogenetic protein; BMP; Transforming growth factor; TGFβ; Pancreatic intra epithelial lesions; PanIN; Pancreatic ductal adenocarcinom
Keratinocyte Sonic Hedgehog Upregulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1Â Secretion
Keywords: خیر; BCC; basal cell carcinoma; CC; Collaborative Cross; EDN; endothelin; hgf; hepatocyte growth factor; P10; postnatal day 10; Shh; sonic hedgehog; Smo; smoothened;
Reduced Smoothened level rescues Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease
Keywords: خیر; Alzheimer disease; Inflammation; Learning and memory; Smoothened; AD; Alzheimer's disease; SHH; sonic hedgehog; ALS; amyotrophic lateral sclerosis; NPC; Niemann-Pick disease type C; AD flies; Aβ expressing flies; AMPs; antimicrobial peptides;
Medulloblastoma in Older Adults: A Case Report and Literature Review
Keywords: خیر; Chemotherapy; Medulloblastoma; Molecular subtype; Older adults; MRI; Magnetic resonance imaging; SHH; Sonic hedgehog; WHO; World Health Organization; WNT; Wingless;
Sonic hedgehog regulates the pathfinding of descending serotonergic axons in hindbrain in collaboration with Wnt5a and secreted frizzled-related protein 1
Keywords: خیر; Shh; Sonic Hedgehog; Sfrp1; Secreted frizzled-related protein 1; PCP; planar cell polarity; 5-HT; 5-hydroxytryptamine; E10.5; Embryonic day 10.5; A-P; Anterior to posterior; Fzd3; Frizzled 3; DMSO; Dimethylsulfoxide; Ptch1; Patched 1; Smo; Smoothened; R4;
Biogenesis and function of ESCRT-dependent extracellular vesicles
Keywords: خیر; Aβ; amyloid-β protein; Acb1; acyl CoA binding protein1; ALIX; ALG-2 interacting protein X; APP; amyloid precursor protein; ARRDC1; ARRestin domain-containing protein 1; COPI/II; coat protein complex I/II; CUPS; compartment for unconventional protein sec
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo
Keywords: خیر; Hedgehog inhibitor; In vivo pharmacokinetics; Gram-scale synthesis; ADME-Tox; LS180 xenograft; Acylguanidine; Hh; Hedgehog; Shh; Sonic Hedgehog; Ptch; Patched; Smo; Smoothened; BCC; basal cell carcinoma; PE; petroleum ether; SRB; sulforhodamine B; Shh-CM
Nerves, H2O2 and Shh: Three players in the game of regeneration
Keywords: خیر; Regeneration; Hydrogen peroxide; Nerves; Shh;
Hedgehog signaling negatively co-regulates BH3-only protein Noxa and TAp73 in TP53-mutated cells
Keywords: خیر; Apoptosis; Cell death; Noxa; TAp73; EGR1; GANT61; Hedgehog signaling; Rhabdomyosarcoma; Medulloblastoma; ARMS; alveolar RMS; CNS; central nervous system; DSMZ; Deutsche Sammlung von Mikroorganismen und Zellkulturen; EGR1; early growth response protein 1;
Tackling destructive proteolysis of unconventionally secreted heterologous proteins in Ustilago maydis
Keywords: خیر; CBB; coomassie brilliant blue staining; CM; complete medium; glc; glucose; Gus; β-glucuronidase; HRP; horse radish peroxidase; IMAC; immobilized metal ion affinity chromatography; MCS; multiple cloning site; OTR; oxygen transfer rate; RAMOS; respiration
The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: A review
Keywords: خیر; AM; Atractylodes macrocephala Koidz.; TCM; traditional Chinese medicine; UPLC; ultra-performance liquid chromatography; PDA; photo-diode array; IR; infrared spectroscopy; HS-LP-LPE; headspace liquid phase-liquid-phase extraction; GC-MS; gas chromatography
Cardiac repair by epicardial EMT: Current targets and a potential role for the primary cilium
Keywords: خیر; BBS8; Bardet-Biedl syndrome 8; bFGF; basic fibroblast growth factor; BMP; bone morphogenetic protein; BMSCs; bone marrow-derived hematopoietic stem cells; ECM; extracellular matrix; EGF; epidermal growth factor; EMT; epithelial-to-mesenchymal transition;
Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo
Keywords: خیر; Arsenic trioxide; Cisplatin; Combination therapy; Bcr-Abl-positive leukemia; Apoptosis; APL; acute promyelocytic leukemia; ATO; arsenic trioxide; Ato-C; ATO/CDDP; CDDP; Cisplatin; CI; combination index; DRI; dose-reduction index; CML; Chronic myelogenous
Impact of microRNAs on ischemic stroke: From pre- to post-disease
Keywords: خیر; AAV; adeno-associated virus; ABCA1; ATP-binding cassette transporter 1; AGO; argonaute; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionate; AT1R; angiotensin II type 1 receptor; AQPs; aquaporins; BBB; blood-brain barrier; Bcl-6; B-cell lymphoma-6;
Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner
Keywords: خیر; 5-HT; 5-hydroxytryptamine; Aβ; β-amyloid; ABCA8; ATP binding cassette subfamily A member 8; AD; Alzheimer's disease; ADP; adenosine diphosphate; AGD; argyrophilic grain disease; ALS; amyotrophic lateral sclerosis; AMBRA-1; autophagy and beclin 1 regul
Usp7 promotes medulloblastoma cell survival and metastasis by activating Shh pathway
Keywords: خیر; Usp7; Medulloblastoma; Shh; P53; CRISPR/Cas9;
Comparative analysis of the neurula transcriptomes of two species of flatfishes: Platichthys stellatus and Paralichthys olivaceus
Keywords: خیر; BMP; Bone Morphogenetic Protein; BMPR; Bone Morphogenetic Protein Receptor; BLAST; Basic Local Alignment Search Tool; ERBB; Erb-b2 Receptor Tyrosine Kinase; FGF; Fibroblast Growth Factor; FGFR; Fibroblast Growth Factor Receptor; FZ; Frizzled; HOXB1B; Home
Rhizosphere microorganisms affected by soil solarization and cover cropping in Capsicum annuum and Phaseolus lunatus agroecosystems
Keywords: خیر; CAS; Chrome Azurol S medium; CP; cowpea cover crop; CPH; cowpea hay; F; fallow; FSS; flat surface solarization; MB; methyl bromide; NH; no hay; OSM; Ohio State medium; RBS; raised-bed solarization; SS; soil solarizatio; SH; sunn hemp; SHH; sunn hemp hay;
Identification and characterization of two novel PTCH1 splice variants
Keywords: خیر; Patched-1; Splice variants; Exon skipping; SHH; Sterol-sensing domain; GLI1;
Detailed expression profile of the six Glypicans and their modifying enzyme, Notum during chick limb and feather development
Keywords: خیر; Shh; Sonic Hedgehog; Fgf; fibroblast growth factor; BMP; bone morphogenetic protein; AER; apical ectodermal ridge; ZPA; zone of polarising activity; Chick; Limb; Feather; Development glypican; Notum;
Immuno-detection of cleaved SNAP-25 from differentiated mouse embryonic stem cells provides a sensitive assay for determination of botulinum A toxin and antitoxin potency
Keywords: خیر; BoNT/A; botulinum neurotoxin A; SNAP-25; synaptosomal protein of molecular mass 25Â kDa; EB; embryoid bodies; ESDN; embryonic stem cell-derived neurons; mESC; mouse embryonic stem cells; HC; heavy chain; LC; light chain; LHn/A; recombinant endopeptidase f