Keywords: SIRT3; PHD; DMOG; Diastolic dysfunction; Induction of hypoxia tolerance;
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Keywords: AMPK; OGT; PPARδ; SIRT3; TXNIP;
Keywords: AA; Antimycin A; ADFI; average daily feed intake; ADG; average daily gain; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; CAT; catalase; CR; caloric restriction; CS; citrate synthase; cyt b; cytochrome b; ESRRA; estrogen-related receptor
Keywords: AMPK; AMP-activated protein kinase; DCA; Dichloroacetate; FACD; Fatty acyl CoA dehydrogenase; G-6-Pase; Glucose-6-phosphatase; HFD; High-fat diet; HGP; Hepatic glucose production; KCT; β-ketoacyl CoA thiolase; LDH; Lactate dehydrogenase; MPC; Mitochondri
Keywords: Mitochondria; Acetylation; SIRT3; Epilepsy; Mass spectrometry; Proteomics;
Keywords: Metformin; Heart failure; Mitochondrial energy metabolism; Sirt3; PGC-1α;
Keywords: AD; Alzheimer's disease; ADF; alternate day fasting; ALS; amyotrophic lateral sclerosis; APP; β-amyloid precursor protein; BDNF; brain-derived neurotrophic factor; CER; continuous energy restriction; CR; caloric restriction; CREB; cyclic AMP response e
Keywords: Aging; Cardiovascular Disease Risk Factors; Human Corpus Cavernosum; SIRT1; SIRT2; SIRT3; SIRT5; SIRT6; SIRT7;
Keywords: Acetylation; Sirt3; GCN5L1; Mitophagy; Autophagy;
Keywords: Epigenetics; Phytochemicals; DNA-methylation; Histone-modification; miRNA; Carcinogenesis; Akt; v-akt murine thymoma viral oncogene homolog 1; AP-1; Activator Protein-1; Bax; BCL2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; Bcl-xL; B-cell lymphoma-
Keywords: NRTI; Lon; SIRT3; eIF2α; Mitochondrial stressAAA+, ATPases associated with diverse cellular activities; AZT, Zidovudine; CHOP, CCAAT-enhancer-binding protein homologous protein; d4T, Stavudine; eIF2α, eukaryotic translation initiation factor 2α; ER, endop
Keywords: SIRT3; EMT; Twist; Metastasis; Ovarian carcinoma
SIRT3 inactivation promotes acute kidney injury through elevated acetylation of SOD2 and p53
Keywords: Ischemia/reperfusion; Acute kidney injury; SIRT3; Deacetylation; p53; SOD2;
Sirt3 attenuates post-infarction cardiac injury via inhibiting mitochondrial fission and normalization of AMPK-Drp1 pathways
Keywords: Sirt3; Post-infarction cardiac injury; Mitochondrial fission; AMPK-Drp1 pathways;
PGC1α is required for the induction of contact inhibition by suppressing ROS
Keywords: PGC1α; Cell density; Contact inhibition; ROS; SIRT3;
Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D
Keywords: Ganoderic acid D; SIRT3; Warburg effect; Glucose metabolism; Colon cancer; Cyclophilin D;
Vosaroxin induces mitochondrial dysfunction and apoptosis in cervical cancer HeLa cells: Involvement of AMPK/Sirt3/HIF-1 pathway
Keywords: Cervical cancer; Mitochondrial dysfunction; Sirt3; HIF-1;
Potential role of the mitochondria as a target for the hepatotoxic effects of (-)-epigallocatechin-3-gallate in mice
Keywords: Green tea; (-)-Epigallocatechin-3-gallate; Hepatotoxicity; Oxidative stress; Mitochondria; ALT; alanine aminotransferase; AST; aspartate aminotransferase; MT-Co2; cytochrome oxidase subunit II; EGCG; (-)epigallocatechin-3-gallate; FOXO3a; forkhead box O3a
Sirt1-Sirt3 axis regulates human blood-brain barrier permeability in response to ischemia
Keywords: Stroke; Blood-brain barrier; Sirt1; Sirt3; Mitochondrial ROS;
LanCL1 attenuates ischemia-induced oxidative stress by Sirt3-mediated preservation of mitochondrial function
Keywords: LanCL1; Oxygen and glucose deprivation; Oxidative stress; Sirt3; PGC-1α;
Expression of SIRT3 in various glial cell types in the periventricular white matter in the neonatal rat brain after hypoxia
Keywords: SIRT3; Glial cells; Hypoxia;
Sirt3 confers protection against acrolein-induced oxidative stress in cochlear nucleus neurons
Keywords: Acrolein; Mitochondrial dysfunction; ER stress; Sirt3;
Icariside II alleviates oxygen-glucose deprivation and reoxygenation-induced PC12 cell oxidative injury by activating Nrf2/SIRT3 signaling pathway
Keywords: Icariside II; Oxygen-glucose deprivation; Reoxygenation; Oxidative injury; Apoptosis; Nrf2; SIRT3;
Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway
Keywords: ADH; alcohol dehydrogenase; ALD; Alcoholic liver disease; ALDH; aldehyde dehydrogenase; CPT-1α; carnitine palmitoyl transterase-1α; CR; calorie restriction; CS; citrate synthase; CYP2E1; cytochrome P450 2E1; FASN; fatty acid synthase; NAD+; nicotinamide
Honokiol protects pulmonary microvascular endothelial barrier against lipopolysaccharide-induced ARDS partially via the Sirt3/AMPK signaling axis
Keywords: ARDS; Honokiol; Pulmonary microvascular endothelial barrier; Sirt3; Ang-2;
Hydrogen sulfide attenuates oxidative stress-induced NLRP3 inflammasome activation via S-sulfhydrating c-Jun at Cys269 in macrophages
Keywords: ANOVA; analysis of variance; BMM; bone marrow-derived macrophages; BSA; bovine serum albumin; CVD; cardiovascular diseases; DAPI; 4â²,6-diamidino-2-phenylindole; DMSO; dimethyl sulphoxide; DHE; dihydroethidium; EDTA; ethylenediaminetetraacetic acid; FBS;
Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism
Keywords: Hepatic steatosis; SIRT3; Long-chain acyl coenzyme A dehydrogenase; Deacetylation;
Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy
Keywords: Nonalcoholic fatty liver disease; Mitophagy; Bnip3; Sirt3; ERK-CREB signalling pathway;
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3
Keywords: HHcy; hyperhomocysteinemia; SAL; salidroside; HFD; high methionine diet; ECs; endothelial cells; SMCs; smooth muscle cells; ROS; reactive oxygen species; HUVECs; human umbilical vein endothelial cells; ECM; endothelial cell medium; PVDF; polyvinylidene di
GADD45β-I attenuates oxidative stress and apoptosis via Sirt3-mediated inhibition of ER stress in osteoarthritis chondrocytes
Keywords: Osteoarthritis; Chondrocyte; ER stress; Oxidative stress; Sirt3;
miR-494-3p modulates the progression of in vitro and in vivo Parkinson's disease models by targeting SIRT3
Keywords: PD; Parkinson's disease; SOD; superoxide dismutase; LDH; lactate dehydrogenase; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; ROS; reactive oxygen species; SNpc; substantia nigra pars compacta; DA; dopaminergic; miRNAs; microRNAs; snRNA; sm
Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3
Keywords: Honokiol; Oxidative stress; Liver; SIRT3; Mitochondria; Fragmentation;
Metabolic reprogramming in colon cancer reversed by DHTS through regulating PTEN/AKT/HIF1α mediated signal pathway
Keywords: DHTS; dihydrotanshinone I; LCFAs; long-chain fatty acids; PTEN; phosphatase and tensin homolog gene; HIF1α; hypoxia inducible factor 1 alpha; HKII; hexokinase II; p-AKT; phosphorylated protein kinase B; RHEB; Ras homolog enriched in brain; SIRT3; Silent
Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation
Keywords: NLRP3; Nod-like receptor family, pyrin domain-containing 3; HAECs; human aortic endothelial cells; MCM; macrophage-conditioned medium; MnSOD; manganese superoxide dismutase; mtROS; mitochondrial reactive oxygen species; PMA; phorbol-12-myristate-13-acetat
Non-tumor adjacent tissue of advanced stage from CRC shows activated antioxidant response
Keywords: CRC; colorectal cancer; SIRT3; sirtuin 3; MSI; microsatellite instability; NRAS; neuroblastoma RAS viral oncogene homolog; BRAF; v-raf murine sarcoma viral oncogene homolog B; KRAS; Kirsten rat sarcoma viral oncogene homolog; PI3K; phosphatidylinositide 3
Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells
Keywords: Sirtuin 3; Neovascularization; Retinal endothelial cells; Migration; Autophagy; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HGI; high glucose and insulin; HIF-1α; hypoxia-inducible factor 1α; HRECs; human retinal endothelial cells; IGF-1; insulin-l
Original ArticleLow SIRT3 expression contributes to tumor progression, development and poor prognosis in human pancreatic carcinoma
Keywords: SIRT3; Pancreatic carcinoma; Biomarker; Prognosis;
SIRT3 deacetylated and increased citrate synthase activity in PD model
Keywords: Parkinson disease; SIRT3; Deacetylation; Neuroprotection; Enzyme activity; Mitochondria; PD; Parkinson's disease; DA; dopaminergic; ATP; adenosine triphosphate; CS; citrate synthase; IDH2; isocitrate dehydrogenase 2; TCA; citric acid cycle; PDH; pyruvated
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis
Keywords: Atherosclerosis; CVD; Sirtuin; SIRT1; SIRT3; SIRT6; Oxidative stress; Lipid metabolism; ABC; Adenosine triphosphate binding cassette; ABCG; ABC sub-family G member; ADP; Adenosine diphosphate; AMPK; Adenosine monophosphate-activated protein kinase; eNOS;
Curcumin attenuates skeletal muscle mitochondrial impairment in COPD rats: PGC-1α/SIRT3 pathway involved
Keywords: Chronic obstructive pulmonary disease; Curcumin; Mitochondria; PGC-1α; SIRT3;
ZL006 protects spinal cord neurons against ischemia-induced oxidative stress through AMPK-PGC-1α-Sirt3 pathway
Keywords: Spinal cord ischemia; PSD-95; nNOS; Sirt3; Mitochondrial dysfunction;
Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway
Keywords: Ischemic stroke; Sirt3; Autophagy; AMPK; mTOR;
SIRT3 and mitochondrial metabolism in neurodegenerative diseases
Keywords: Amyotrophic lateral sclerosis; Mitochondria; Energy balance; Neurodegeneration; SIRT3; AD; Alzheimer's disease; ALS; Amyotrophic Lateral Sclerosis; GSH; reduced glutathione; GSSG; oxidized glutathione; IDH2; isocitrate dehydrogenase 2; LCAD; long-chain ac
Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction
Keywords: SIRT3; PFKFB3; Metabolic reprogram; Coronary microvascular dysfunction; Diastolic dysfunction; 2-DG; 2-deoxyglucose; 3PO; 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one; Ang-1; Angiopoietin-1; CFR; Coronary flow reserve; DHE; Dihydroethidium; ECAR; Extrac
Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor
Keywords: Q; Coenzyme Q; 2,4-DHB; 2,4-dihydroxybenzoic acid; DOD; drop-out-dextrose medium; FBS; fetal bovine serum; 4HB; 4-Hydroxybenzoic acid; 4HPAA; 4-hydroxyphenylacetic acid; MEF; mouse embryonic fibroblast; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetraz
A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase
Keywords: SIRT3; NAD-dependent deacetylase sirtuin-3; MnSOD; manganese superoxide dismutase; HDAC; histone deacetylase; ROS; reactive oxygen species; NR; nicotinamide riboside; STACs; sirtuin-activating compounds; MnSOD; SIRT3; Acetylation; Superoxide; Electrostati
Polydatin ameliorates diabetic cardiomyopathy via Sirt3 activation
Keywords: Polydatin; PD; Diabetes; DM; Autophagy; Sirt3; Mitochondria;
Resveratrol rescues cadmium-induced mitochondrial injury by enhancing transcriptional regulation of PGC-1α and SOD2 via the Sirt3/FoxO3a pathway in TCMK-1 cells
Keywords: Resveratrol; Cadmium; Mitochondria; Nephrotoxicity; Sirt3;
Metformin ameliorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis based on the SIRT3 signaling pathway
Keywords: Que; Quercetin; I/R; Ischemia/reperfusion; H/R; Hypoxia/reoxygenation; LDH; Lactate dehydrogenase; SOD; Superoxide dismutase; MDA; Malondialdehyde; ROS; Reactive oxygen species; TSA; TrichostatinA; FACS; Flow cytometric analysis; MAPKs; Mitogen-activated
SIRT3 inhibits Ang II-induced transdifferentiation of cardiac fibroblasts through β-catenin/PPAR-γ signaling
Keywords: SIRT3; PPARγ; β-catenin; Transdifferentiation; Cardiac fibroblasts;