کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5500644 | 1534294 | 2017 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of intermittent fasting on health and disease processes
ترجمه فارسی عنوان
تأثیر ناگهانی متناوب در فرآیندهای بهداشتی و بیماری
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کلمات کلیدی
ADFPMP22Hsp-70Sirtuin 3Sirt3FMDsirtuin 1GRP-78PGC-1αFGF2MPTPIGF-1APPFFMERKmTORSirt1CREBIL-6TRF1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridineBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Myocardial infarction - آنفارکتوس میوکاردamyotrophic lateral sclerosis - اسکلروز جانبی آمیوتروفیکinterleukin 6 - اینترلوکین 6Ketone bodies - بدن کتونAlzheimer’s disease - بیماری آلزایمرALS - بیماری اسکلروز جانبی آمیوتروفیکcardiovascular disease - بیماری قلب و عروقیDiabetes - بیماری قندHuntington’s disease - بیماری هانتینگتونParkinson’s disease - بیماری پارکینسونTime-restricted feeding - تغذیه با محدودیت زمانیfat-free mass - توده بدون چربیtumor necrosis factor α - تومور نکروز عامل αCVD - رسوب دهی شیمیایی بخار Alternate day fasting - روزهای متناوب روزهCer - سرextracellular signal regulated kinase - سیگنال خارج سلولی kinase را تنظیم می کندfibroblast growth factor 2 - عامل رشد فیبروبلاست 2insulin-like growth factor 1 - فاکتور رشد مانند انسولین 1Brain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزTNF-α - فاکتور نکروز توموری آلفاBlood pressure - فشارخونcaloric restriction - محدودیت کالریObesity - مرض چاقیInsulin resistance - مقاومت به انسولینIntermittent fasting - ناگهانی متناوبmammalian target of rapamycin - هدف پستانداران رپامایسینcyclic AMP response element-binding protein - پروتئین اتصال دهنده عنصر Response Cyclic AMPheat-shock protein 70 - پروتئین حرارت دهنده 70β-amyloid precursor protein - پروتئین پیش ماده β-آمیلوئیدPeripheral myelin protein 22 - پرولین پرولیئین محیطی 22glucose regulated protein 78 - گلوکز پروتئین تنظیم شده 78Mineralocorticoid receptor - گیرنده مینرالوکورتیکوئید glucocorticoid receptor - گیرنده گلوکوکورتیکوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Humans in modern societies typically consume food at least three times daily, while laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns often leads to metabolic morbidities (insulin resistance, excessive accumulation of visceral fat, etc.), particularly when associated with a sedentary lifestyle. Because animals, including humans, evolved in environments where food was relatively scarce, they developed numerous adaptations that enabled them to function at a high level, both physically and cognitively, when in a food-deprived/fasted state. Intermittent fasting (IF) encompasses eating patterns in which individuals go extended time periods (e.g., 16-48Â h) with little or no energy intake, with intervening periods of normal food intake, on a recurring basis. We use the term periodic fasting (PF) to refer to IF with periods of fasting or fasting mimicking diets lasting from 2 to as many as 21 or more days. In laboratory rats and mice IF and PF have profound beneficial effects on many different indices of health and, importantly, can counteract disease processes and improve functional outcome in experimental models of a wide range of age-related disorders including diabetes, cardiovascular disease, cancers and neurological disorders such as Alzheimer's disease Parkinson's disease and stroke. Studies of IF (e.g., 60% energy restriction on 2Â days per week or every other day), PF (e.g., a 5Â day diet providing 750-1100Â kcal) and time-restricted feeding (TRF; limiting the daily period of food intake to 8Â h or less) in normal and overweight human subjects have demonstrated efficacy for weight loss and improvements in multiple health indicators including insulin resistance and reductions in risk factors for cardiovascular disease. The cellular and molecular mechanisms by which IF improves health and counteracts disease processes involve activation of adaptive cellular stress response signaling pathways that enhance mitochondrial health, DNA repair and autophagy. PF also promotes stem cell-based regeneration as well as long-lasting metabolic effects. Randomized controlled clinical trials of IF versus PF and isoenergetic continuous energy restriction in human subjects will be required to establish the efficacy of IF in improving general health, and preventing and managing major diseases of aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 39, October 2017, Pages 46-58
Journal: Ageing Research Reviews - Volume 39, October 2017, Pages 46-58
نویسندگان
Mark P. Mattson, Valter D. Longo, Michelle Harvie,