کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8548529 | 1561736 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Potential role of the mitochondria as a target for the hepatotoxic effects of (-)-epigallocatechin-3-gallate in mice
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کلمات کلیدی
FOXO3aMT-CO2Rps18MDACytochrome oxidase subunit II(-)-Epigallocatechin-3-gallatephosphorylated histone 2AXSirtuin 3PGC1αGPx1γH2AXSirt3SOD2HPLC-ECDGSHEGCGGAPDHALTqRT-PCRqPCRQuantitative PCR - PCR کمیAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازTem - این استOxidative stress - تنش اکسیداتیوforkhead box O3a - جعبه جعبه O3aHepatotoxicity - سمیت کبدmalondialdehyde - مالون دی آلدهیدMitochondria - میتوکندریاTransmission electron microscopy - میکروسکوپ الکترونی عبوریGreen tea - چای سبزreduced glutathione - کاهش گلوتاتیونhigh performance liquid chromatography with electrochemical detection - کروماتوگرافی مایع با کارایی بالا با تشخیص الکتروشیمیاییglutathione peroxidase 1 - گلوتاتیون پراکسیداز 1glyceraldehyde-3 phosphate dehydrogenase - گلیسرالیدید-3 فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Potential role of the mitochondria as a target for the hepatotoxic effects of (-)-epigallocatechin-3-gallate in mice Potential role of the mitochondria as a target for the hepatotoxic effects of (-)-epigallocatechin-3-gallate in mice](/preview/png/8548529.png)
چکیده انگلیسی
Green tea and (-)-epigallocatechin-3-gallate (EGCG) have been studied for their obesity-related health effects. Many green tea extract (GTE)-based dietary supplements are commercially-available. Although green tea beverage has a long history of safe use, a growing number of case-reports have linked GTE-based supplements to incidents of hepatotoxicity. Animal studies support the hepatotoxic potential of GTE and EGCG, but the mechanisms remain unclear. Here, we examined the hepatotoxic effects of EGCG in C57BL/6J mice and evaluated changes in hepatic antioxidant response and mitochondria structure and function. Intragastric dosing with EGCG (500 - 750 mg/kg) once daily for 3 d caused hepatic inflammation, necrosis, and hemorrhage. Hepatotoxicity was associated with increased oxidative stress and decreased superoxide dismutase and glutathione peroxidase levels. Real-time PCR and transmission electron microscopy showed decreased hepatic mitochondria copy number in EGCG-treated mice. The mRNA levels of marker genes of respiratory complex I and III, sirtuin 3, forkhead box O3a, and peroxisome-EGCG-treated mice. Sirtuin 3 protein levels were also decreased by EGCG. Our data indicate the mitochondria may be a target for EGCG, and that inhibition of mitochondria function/antioxidant response may be important for the hepatotoxicity of bolus EGCG.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 111, January 2018, Pages 302-309
Journal: Food and Chemical Toxicology - Volume 111, January 2018, Pages 302-309
نویسندگان
Karma D. James, Mary J. Kennett, Joshua D. Lambert,