Keywords: Bax; Bcl-2-associated X protein; CHOP; C/EBP-homologous protein 10; DNA; dezoxiribonucleic acid; FITC; fluorescein isothiocyanate; GAPDH; (Glyceraldehyde 3-phosphate dehydrogenase; GRP78; glucose-regulated protein 78; HIF1α; hypoxia inducible factor 1α;
مقالات ISI (ترجمه نشده)
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Keywords: Carcinogenesis; Chemoprevention; Chemotherapy; Oxidative stress; Nrf2; Phytochemicals; AKT; protein kinase B; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ATF-2; activating transcriptional factor; BBN; N-butyl-N-(4-hydroxybutyl)n
Keywords: Esophagus; Sequencing; Carcinogenesis; Driver Mutation; APOBEC; apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like; CNA; copy number alteration; EAC; esophageal adenocarcinoma; ESCC; esophageal squamous cell carcinoma; ESSH; esophag
Keywords: DTC; dithiocarbamates; EGCG; (-)-epigallocatechin-3-gallate; DSF; disulfiram; DEDTC; diethyldithiocarbamate; PDTC; pyrrolidine dithiocarbamate; SOD; superoxide dismutase; MT; metallothionein; ROS; reactive oxygen species; γH2AX; histone H2AX; ALT; alanin
Keywords: ADH; alcohol dehydrogenase; BSA; bovine serum albumin; C60HyFn; hydrated C60 fullerene; CNTs; carbon nanotubes; DF-1; dendro[C60]fullerene-1; DRF; dose reducing factor; DSBs; DNA double-strand breaks; DU145; prostatic adenocarcinoma cell line; ESR; electr
Keywords: A-bomb; atomic bomb; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; ATPase; adenosine triphosphatase; BER; base excision repair; Ca2+; calcium ions; CDKN1A; cyclin-dependent kinase inhibitor 1A; CHO; Chinese hamster ovary; COX-2; cycloox
Keywords: ANP; atrial natriuretic peptide; BNP; brain natriuretic peptide; Brca; breast cancer associated; BW; body weight; Col; collagenase; Con; control; CTGF; connective tissue growth factor; DAPI; 4â²,6-diamidino-2-phenylindole; Doxo; doxorubicin; Gpx1; glutat
Keywords: DIQ; 1,5-dihydroxyisoquinoline; 4-AN; 4-amino-1,8-naphthalimide; 6,4PPs; 6,4-photoproducts; 8-oxodG; 8-oxo-2â²-deoxyguanosine; OGG1; 8-oxoguanine glycosylase 1; APE1; AP-endonuclease; ATM; ataxia telangiectasia-mutated gene; BER; base excision repair; BR
Keywords: Crystalline lens; Ionizing radiation; DNA repair factors; Nontargeted effects; Inflammation; Tumor suppressors; A-bomb; atomic-bomb; Acvr1; activin A type 1 receptor; AP; apurinic/apyrimidinic; APE1; apurinic/apyrimidinic endonuclease 1; AQP; aquaporin; A
Keywords: 17-AAG; 17-(Allylamino)-17-demethoxygeldanamycin; 17-DMAG; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin; AKT; v-akt murine thymoma viral oncogene homolog; APC; antigen presenting cell; ATM; Ataxia telangiectasia mutated; ATR; Ataxia telangiectasia
Keywords: Mouse; Meiosis; Chromatin; Chromosome; Histone modification; DNA methylation; 5mC; 5-methylcytosine; DSB; double strand breaks; γH2AX; phosphorylated histone H2AX; H3K27me3; histone H3 lysine 27 tri-methylation; H3K4me3; histone H3 lysine 4 tri-methylati
Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination
Keywords: DSB; double-strand breaks; HR; homologous recombination; NHEJ; non-homologous end-joining; PARP; poly(ADP-ribose) polymerase; PAR; poly(ADP-ribose); MTT; methyl thiazolyl; PI; propidium iodide; SD; standard deviations; SSB; single strand break; γH2AX; ph
Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models
Keywords: AscH-; ascorbate monoanion (dominant form at biological pH); LIP; labile iron pool; MFI; mean fluorescence intensity; PO-1; PeroxyOrange-1; γH2Ax; phosphorylated histone 2Ax; Sarcoma; Pharmacological ascorbate; Radiation sensitization; Chemotherapy sensi
Potential role of the mitochondria as a target for the hepatotoxic effects of (-)-epigallocatechin-3-gallate in mice
Keywords: Green tea; (-)-Epigallocatechin-3-gallate; Hepatotoxicity; Oxidative stress; Mitochondria; ALT; alanine aminotransferase; AST; aspartate aminotransferase; MT-Co2; cytochrome oxidase subunit II; EGCG; (-)epigallocatechin-3-gallate; FOXO3a; forkhead box O3a
miR-505 enhances doxorubicin-induced cytotoxicity in hepatocellular carcinoma through repressing the Akt pathway by directly targeting HMGB1
Keywords: miR-505; HMGB1; Doxorubicin; γH2AX; Akt pathway; Hepatocellular carcinoma;
The characterization of γH2AX and p53 as biomarkers of genotoxic stress in a rainbow trout (Oncorhynchus mykiss) brain cell line
Keywords: Genotoxicity; Cytotoxicity; γH2AX; p53; Fish; Cell lines;
Genotoxicity analysis of five particle matter toxicants from cigarette smoke based on γH2AX assay combined with Hill/Two-component model
Keywords: DSB; double-strand breaks; ELISA; enzyme-linked immunosorbent assay; WB; western blot; FC; flow cytometry; HCS; high content screening; PAHs; polyaromatic hydrocarbons; WHO FCTC; World Health Organization Framework Convention on Tobacco Control; CCK8; cel
Human sirtuin 3 (SIRT3) deacetylates histone H3 lysine 56 to promote nonhomologous end joining repair
Keywords: DNA repair; HDACs; 53BP1; BRCA1; Nuclear sirtuin; γH2AX;
DNA damage and repair proteins in cellular response to sulfur mustard in Iranian veterans more than two decades after exposure
Keywords: CHK1; checkpoint kinase 1 human protein; CHK2; checkpoint kinase 2 human protein; COPD; chronic obstructive pulmonary disease; DSB; double-strand breaks; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSH; glutathione; γH2AX; phosphorylated H2AX; MRN;
Two Weeks of Variable Stress Increases Gamma-H2AX Levels in the Mouse Bed Nucleus of the Stria Terminalis
Keywords: BNST; bed nucleus of the stria terminalis; DSBs; double-strand breaks; GSK3β; glycogen synthase kinase 3 β; MAPK; mitogen-activated protein kinase; mPFC; medial prefrontal cortex; PBS; phosphate-buffered saline; γH2AX; Histone H2A-X phosphorylated at s
Irradiation by γ-rays reduces the level of H3S10 phosphorylation and weakens the G2 phase-dependent interaction between H3S10 phosphorylation and γH2AX
Keywords: Mass spectrometry; Histones H3 and H4; γH2AX; DNA damage; Embryonic stem cells; Epigenetics; FLIM; Fluorescence lifetime image microscopy; FRET; Förster resonance energy transfer; H3; histone H3; H4; histone H4; me1; monomethylated histones; me2; dimeth
Inhibition of Rad51 sensitizes breast cancer cells with wild-type PTEN to olaparib
Keywords: PTEN; Phosphatase and tensin homologue; PARP; poly(ADP-ribose) polymerase; PI3K; PI3 kinase; RPA1; replication protein A1; DSB; double-strand breaks; HR; homologous recombination; SSB; single strand breaks; γH2AX; Phospho-histone H2AX; PMSF; phenylmethyl
Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome
Keywords: CPC; choroid plexus carcinoma; DSBs; double-strands breaks; LFS; Li-Fraumeni syndrome; mFISH; multicolour fluorescence in-situ hybridization; NHEJ; non-homologous end-joining; SEM; scanning electron microscopy; TEM; transmission electron microscopy; γH2A
Cytotoxicity and genotoxicity effects of arsenic trioxide on SQ20B human laryngeal carcinoma cells
Keywords: Arsenic trioxide; DNA damage; Head and neck carcinoma cells; γH2AX; DNA double-strand breaks; Apoptosis;
Downregulation of UBE2E2 in rat liver cells after hepatocarcinogen treatment facilitates cell proliferation and slowing down of DNA damage response in GST-P-expressing preneoplastic lesions
Keywords: AOM; azoxymethane; BBN; N-butyl-N-(4-hydroxybutyl)nitrosamine; BNF; β-naphthoflavone; CF; clofibrate; DEHP; bis(2-ethylhexyl) phthalate; DEN; N-nitrosodiethylamine; DHPN; N-bis(2-hydroxypropyl)nitrosamine; FB; fenbendazole; γH2AX; phosphorylated H2A his
Imaging neuronal pathways with 52Mn PET: Toxicity evaluation in rats
Keywords: 52Mn; Manganese toxicity; Neuronal pathways; PET; γH2AX; Rat;
Assessment of genotoxicity of four volatile pollutants from cigarette smoke based on the in vitro γH2AX assay using high content screening
Keywords: γH2AX; High content screening; Aldehyde; Benzene; Dose/time-response;
Triggering autophagic cell death with a di-manganese(II) developmental therapeutic
Keywords: γH2AX; phosphorylated H2AX histone; caspase; cysteine-dependent asparate-specific proteases CAT, catalase; CCCP; carbonyl cyanide m-chlorophenyl hydrazine; Dox; doxorubicin; DSB; double strand breaks; LC-3; microtubule associated protein 1 light weight c
Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin
Keywords: Photochemical internalization; Photodynamic; Sarcoma; Bleomycin; γH2AX; Resistance; Reactive oxygen species; Glutathione;
Copper-mediated DNA damage by the neurotransmitter dopamine and L-DOPA: A pro-oxidant mechanism
Keywords: Copper; L-DOPA; Dopamine; γH2AX; DNA damage; Neurotoxicity;
Relationship between spontaneous γH2AX foci formation and progenitor functions in circulating hematopoietic stem and progenitor cells among atomic-bomb survivors
Keywords: Hematopoietic stem and progenitor cells; γH2AX; Telomere length; DNA damage; Atomic-bomb; Self-renewability;
Guanine-quadruplexes are increased in mild cognitive impairment and correlate with cognitive function and chromosomal DNA damage
Keywords: γH2AX; Blood biomarkers; Guanine-quadruplex; Lymphocytes; Mild cognitive impairment;
Melanogenesis and DNA damage following photodynamic therapy in melanoma with two meso-substituted porphyrins
Keywords: Photodynamic therapy; Melanoma; Meso-substituted porphyrins; Melanogenesis; γH2AX;
Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics
Keywords: 53BP1; tumor suppressor p53 binding protein 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related; Chk; checkpoint kinase; DSB; DNA double-strand break; DDR; DNA damage response; DNA-PKcs; DNA-dependent protein kinase, catalyt
Activation of the Fanconi anemia/BRCA pathway at low doses of ionization radiation
Keywords: Fanconi anemia; Ionizing radiation; FANCD2; γH2AX; DNA damage response;
DNA double strand breaks in human spermatozoa can be predictive for assisted reproductive outcome
Keywords: double strand breaks; ICSI outcome; male infertility; sperm DNA fragmentation; γH2AX;
Development of pharmacodynamic biomarkers for ATR inhibitors
Keywords: ATR; pChk1; γH2AX; PBMC; UV; 4NQO; Biomarker;
The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells
Keywords: BCS; breast cancer cell; ER; oestrogen receptor; CSC; cancer stem cell; FACS; fluorescence activated cell sorting; γH2AX; gamma-histone 2AX; mTOR; mammalian/mechanistic target of rapamycin; PARP; poly(ADP-ribose) polymerase; BCL-2; B-cell lymphoma-2; Bax
Ablation of Foxl1-Cre-Labeled Hepatic Progenitor Cells and Their Descendants Impairs Recovery of Mice From Liver Injury
Keywords: HPCs; Oval Cells; Mouse Model; Nonalcoholic Fatty Liver Disease; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CDE; choline-deficient, ethionine-supplemented; CK19; Cytokeratin 19; CreER; Cre-estrogen receptor
Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury
Keywords: ApG; adenine-guanine; ATM; Ataxia telangiectasia mutated; ATR; ATM and Rad3 related kinase; Bax; Bcl2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; EdU; 5-ethynyl-2â²-deoxyuridine; CarboPt; carboplatin; CENP-F; centromere protein F; Chk1; checkpoint
Space experiment “Cellular Responses to Radiation in Space (CellRad)”: Hardware and biological system tests
Keywords: ATM; Ataxia telangiectasia mutated; CellRad; Cellular Responses to Radiation in Space; CMV; cytomegalovirus; d2EGFP; destabilized variant of EGFP; DDR; DNA damage response; DSB; double strand breaks; DLR; German Aerospace Center; DMSO; dimethyl sulfoxide;
Persistent γH2AX: A promising molecular marker of DNA damage and aging
Keywords: γH2AX; Ionizing radiation; DNA damage; Aging;
SOX9 Maintains Reserve Stem Cells and Preserves Radioresistance in Mouse Small Intestine
Keywords: Irradiation Injury; Intestinal Epithelium; Radioresistant Stem Cells; Gene Expression; aISC; active intestinal stem cell; EdU; ethynyl deoxyuridine; EGFP; enhanced green fluorescent protein; FACS; fluorescence-activated cell sorting; γH2AX; γ H2A histon
Selenite activates the ATM kinase-dependent DNA repair pathway in human osteosarcoma cells with mitochondrial dysfunction
Keywords: Mitochondrial dysfunction; Selenite; DNA repair; ATM kinase; Oxidative damage; ATM; ataxia teleangiectasia mutated kinase; BRCA1; breast cancer 1; DAF-FM; 4-Amino-5-methylamino-2â²,7â²-difluorofluorescein; DAPI; 4â²,6-diamidino-2-phenylindole; DBS; dou
Phosphorylation of PTEN at STT motif is associated with DNA damage response
Keywords: Phosphatase and tensin homolog deleted from chromosome Ten (PTEN); Phosphorylation; DNA damage repair; Mre11; Ku70; γH2AX; Etoposide;
A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA)
Keywords: APC; allophycocyanin; ATR; ataxia telangiectasia mutated and rad3-related; BCA; bicinchoninic acid; Chk1; checkpoint kinase 1; CSK buffer; cytoskeleton buffer; DBU; 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM; dichloromethane; DIPEA; N,N-diisopropylethylamine
PDT-induced epigenetic changes in the mouse cerebral cortex: A protein microarray study
Keywords: ALA; aminolevulinic acid; AP-1/c-Jun; activation protein transcription factor 1; BACH1; breast cancer type1 protein; CENP-E; centromere protein E; hBrm/hsnf2a; chromatin remodeling factor; E2F4; E2F transcription factor 4; FOXC2; forkhead box C2; G9a; his
Residual γH2AX foci predict local tumour control after radiotherapy
Keywords: γH2AX; Radiotherapy; DNA repair; Local tumour control; Tumour micromilieu; Biomarker;
γH2AX foci formation in the absence of DNA damage: Mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway
Keywords: γH2AX; CHK2; DNA-PKcs; DNA damage; Mitosis;
Genotoxicity evaluation of individual cigarette smoke toxicants using the in vitro γH2AX assay by High Content Screening
Keywords: Genotoxicity; In vitro; γH2AX; Cigarette smoke; Tobacco regulation;