Distribution of Smad mRNA and proteins in the rat brain
Keywords: Smad; In situ hybridization; Immunohistochemistry; Rat brain;
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Osthole inhibits the expressions of collagen I and III through Smad signaling pathway after treatment with TGF-β1 in mouse cardiac fibroblasts
Keywords: Osthole; TGF-β1; Collagen I; Collagen III; Smad;
Potent osteogenic activity of a novel imidazobenzimidazole derivative, IBIP
Keywords: IBIP; Osteoblast differentiation; BMP2; SMAD; ERK;
Modulation of TGF-β/Smad and ERK signaling pathways mediates the anti-fibrotic effect of mirtazapine in mice
Keywords: Extracellular signal regulated kinase 1 and 2; 5-HT; 5-HT2A receptor; Mirtazapine; Smad; Transforming growth factor-β1;
TGF-β signalling in tumour associated macrophages
Keywords: Macrophage; TGFbeta; Cancer; Tumour associated macrophages; Smad;
Structural insights into the interaction of a monoclonal antibody and Nodal peptides by STD-NMR spectroscopy
Keywords: ActRIIA; activin type II receptor A; ActRIIB; activin type II receptor B; ALK; activin receptor-like kinase; CFC; Cripto-1/FLR1/cryptic; ECD; extracellular domain; EGF; epidermal growth factor; GEM; Group epitope mapping; mAb; monoclonal antibody; SMAD; S
Inflammation-driven colon neoplasmatogenesis in uPA-deficient mice is associated with an increased expression of Runx transcriptional regulators
Keywords: BMP; bone morphogenetic protein; Cldn1; Claudin1; Co-Smad; common-partner Smad; CRC; colorectal cancer; DSS; dextran sodium sulfate; ECM; extracellular matrix; EMT; epithelial to mesenchymal transition; GALT; gut-associated lymphoid tissue; Id; inhibitor
Mesenchymal Stromal CellsBone marrow-derived mesenchymal stromal cells regress aortic aneurysm via the NF-kB, Smad3 and Akt signaling pathways
Keywords: Akt; aortic aneurysm; bone marrow-derived mesenchymal stromal cells; cell therapy; NF-kB; signaling pathways; Smad; trophic factors;
Induction and maintenance of regulatory T cells by transcription factors and epigenetic modifications
Keywords: Foxp3; Transcription factors; Regulatory T cell; Nr4a; TGF-β; Smad; DNA methylation; Epigenetics;
Dietary Rosa damascena protects against UVB-induced skin aging by improving collagen synthesis via MMPs reduction through alterations of c-Jun and c-Fos and TGF-β1 stimulation mediated smad2/3 and smad7
Keywords: Photoaging; MMP-1; TGF-β; Smad; Collagen; Rosa damascena;
MiR-23b controls TGF-β1 induced airway smooth muscle cell proliferation via direct targeting of Smad3
Keywords: MiR-23b; TGF-β1/Smad3; Asthma; Airway smooth muscle cells; ASMCs; airway smooth muscle cells; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; Smad; drosophila mothers against decapentaplegic protein; FBS; fetal bovine serum; HBSS; Ha
SMAD transcription factors are altered in cell models of HD and regulate HTT expression
Keywords: Huntington's Disease; Transcription; EGF; TGF-beta; SMAD; Kinase signalling;
Upregulation of microRNA-574-3p in a human gastric cancer cell line AGS by TGF-β1
Keywords: miRNA; microRNA; TGF-β1; transforming growth factor-β1; Smad; mammalian homologue of Drosophila Mad and C. elegans Sma; mRISC; miRNA-induced silencing complex; EMT; epithelial-mesenchymal transformation; BSA; bovine serum albumin; NC; negative control;
Redox signaling in the gastrointestinal tract
Keywords: HNE; 4-hydroxynonenal; 8-OHdG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; AP-1; Activator protein 1; APC; Adenomatous polyposis coli; APE-1; Apurinic/apyrimidinic endonuclease 1; Math1; Atonal homolog 1; Bax; BCL2-associated X protein; β-TrCP; Beta-transduci
Klf10 deficiency in mice exacerbates pulmonary inflammation by increasing expression of the proinflammatory molecule NPRA
Keywords: ANP; Atrial natriuretic peptide; BAL; Bronchoalveolar lavage fluid; cGMP; Cyclic guanosine monophosphate; ChIP-PCR; Chromatin immunoprecipitation-polymerase chain reaction; COPD; Chronic obstructive pulmonary disease; EMSA; Electrophoretic mobility shift
The vitamin D receptor agonist, calcipotriol, modulates fibrogenic pathways mitigating liver fibrosis in-vivo: An experimental study
Keywords: Calcipotriol; Vitamin D; Liver fibrosis; TGF; Smad
Sodium humate accelerates cutaneous wound healing by activating TGF-β/Smads signaling pathway in rats
Keywords: Sodium humate; Wound healing; Transforming growth factor-β; Smad; Rat
Unloading results in rapid loss of TGFβ signaling in articular cartilage: role of loading-induced TGFβ signaling in maintenance of articular chondrocyte phenotype?
Keywords: Articular cartilage; Loading; TGFβ; Smad; Hypertrophy;
The dietary flavonoid myricetin regulates iron homeostasis by suppressing hepcidin expression
Keywords: AI; anemia of inflammation; BMP; bone morphogenetic protein; ERK; extracellular signal-regulated kinase; ESAs; erythropoiesis-stimulating agents; HAMP; hepcidin antimicrobial peptide; HJV; hemojuvelin; IL-6; interleukin-6; JAK; Janus kinase; LPS; lipopoly
Tendon mineralization is progressive and associated with deterioration of tendon biomechanical properties, and requires BMP-Smad signaling in the mouse Achilles tendon injury model
Keywords: Achilles tendon; Injury; Ectopic mineralization; Biomechanics; Smad; BMP
Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics
Keywords: RTK; receptor tyrosine kinase; EGF; epidermal growh factor; EGFR; epidermal growth factor receptor; LRIG1; leucin-rich repeats and immunoglobulin-like domains1; MIG; 6mitogen inducible gene 6; RALT; receptor associated late transducer; ERRFI1; ErbB recept
MiR-23b controls TGF-β1 induced airway smooth muscle cell proliferation via TGFβR2/p-Smad3 signals
Keywords: ASMCs; airway smooth muscle cells; BSA; bovine serum albumin; DMEM; Dulbecco's modiï¬ed Eagle's medium; Smad; drosophila mothers against decapentaplegic protein; FBS; fetal bovine serum; HBSS; Hanks' balanced salt solution; NC; negative control; PB
The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle
Keywords: GalNAc; N-acetylgalactosamine; GlcA; glucuronic acid; XT-1; xylosyltransferase-1; GalT-1; β-1,3-galactosyl transferase-1; GlcAT-1; β-1,3-glucuronosyl transferase-1; ChSy-1; chondroitin sulfate synthase-1; ChPF; chondroitin polymerizing factor; ChGn-1; c
NLRC5 regulates TGF-β1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis
Keywords: Liver fibrosis; NLRC5; Hepatic stellate cell; NF-κB; Smad; NLR;
Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling
Keywords: AOS; aneurysm-osteoarthritis syndrome; CTGF; connective tissue growth factor; ECM; extracellular matrix; MFS; Marfan's syndrome; MMP; matrix metalloproteases; TGF-β; transforming growth factor β; VSMC; vascular smooth muscle cell; LDS; Loeys-Dietz syndr
Protopanaxatirol type ginsenoside Re promotes cyclic growth of hair follicles via inhibiting transforming growth factor β signaling cascades
Keywords: Hair growth; Ginsenoside Re; Minoxidil; TGF-β; SMAD; ERK;
Expression of TGFβ-family signalling components in ageing cartilage: age-related loss of TGFβ and BMP receptors
Keywords: Ageing; TGFβ receptors; BMP receptors; Cartilage; Smad;
Angiogenic factor with G patch and FHA domains 1 (Aggf1) regulates liver fibrosis by modulating TGF-β signaling
Keywords: Liver fibrosis; Transcriptional regulation; TGF-β signaling; SMAD; DNA methylation; Hepatic stellate cell;
Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling
Keywords: BMP signaling; Smad; Dynamin; Endocytosis;
Regulation of the TGF-β pathway by deubiquitinases in cancer
Keywords: AMSH; Associated molecule with SH3 domain proteases; AMSH-LP; Associated molecule with SH3 domain-like proteases; ATXN3; ataxin-3; ATXN3L; ataxin 3-like; BMPs; bone morphogenetic proteins; BRCC36; BRCA1/BRCA2-containing complex subunit 36; CHIP; carboxy t
Cooperative induction of transmembrane prostate androgen induced protein TMEPAI/PMEPA1 by transforming growth factor-β and epidermal growth factor signaling
Keywords: TMEPAI; EGF; TGF-β; ELK-1; Smad
BMP4 inhibits myogenic differentiation of bone marrow-derived mesenchymal stromal cells in mdx mice
Keywords: BMPs; BMSCs; Duchenne muscular dystrophy; dystrophin; mdx mice; myogenic differentiation; Smad;
Aspidin PB, a novel natural anti-fibrotic compound, inhibited fibrogenesis in TGF-β1-stimulated keloid fibroblasts via PI-3K/Akt and Smad signaling pathways
Keywords: Keloid fibroblasts; Aspidin PB; TGF-β1; PI-3K/Akt; Smad;
TGF-β-activated SMAD3/4 complex transcriptionally upregulates N-cadherin expression in non-small cell lung cancer
Keywords: NSCLC; CDH2; TGF-β; SMAD; Transcription regulation; EMT;
Crosstalk between calpain activation and TGF-β1 augments collagen-I synthesis in pulmonary fibrosis
Keywords: IPF; idiopathic pulmonary fibrosis; HLFs; human lung fibroblasts; ECM; extracellular matrix; ELISA; enzyme-linked immunosorbent assay; p-Akt; phosphorylated-Akt; t-Akt; total-Akt; p-Smad2/3; phosphorylated-Smad2/3; t-Smad2/3; total-Smad2/3; Calpain; TGF-Î
The potential of asiaticoside for TGF-β1/Smad signaling inhibition in prevention and progression of hypoxia-induced pulmonary hypertension
Keywords: Pulmonary arterial hypertension; Vascular remodeling; TGF-β1; Smad; Asiaticoside;
Apocynin inhibits the upregulation of TGF-β1 expression and ROS production induced by TGF-β in skeletal muscle cells
Keywords: TGF-β1; Smad; ROS; NOX; Atrophy; Skeletal muscle; Ang-II; angiotensin II; NOX; NADPH oxidase; PKC; Ca2+-dependent protein kinase C; ROS; reactive oxygen species; TGF-β1; transforming growth factor type beta 1; TβR; TGF-β receptor;
TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?
Keywords: Pain; Cartilage; TGF-β; NGF; Smad
Fasudil prevents calcium oxalate crystal deposit and renal fibrogenesis in glyoxylate-induced nephrolithic mice
Keywords: Calcium oxalate; Epithelial–mesenchymal transition; Fasudil; Fibrosis; Smad
NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium
Keywords: CAVD; calcific aortic valve disease; ALP; alkaline phosphatase; IBSP; bone sialoprotein; SPARC; osteonectin; TGFβ; transforming growth factor beta; WNT; wingless-type MMTV integration site family; CSL; suppressor of hairless; MAML; mastermind-like protei
Dorsoventral patterning by the Chordin-BMP pathway: a unified model from a pattern-formation perspective for drosophila, vertebrates, sea urchins and nematostella
Keywords: Organizer formation; Pattern formation; Dorsoventral axis; Chordin; BMP; Smad; Sea urchin; Nematostella;
miR-133 modulates TGF-β1-induced bladder smooth muscle cell hypertrophic and fibrotic response: Implication for a role of microRNA in bladder wall remodeling caused by bladder outlet obstruction
Keywords: BOO; bladder outlet obstruction; BSMCs; bladder smooth muscle cells; TGF-β1; transforming growth factor-beta1; ECM; extracellular matrix; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; α-SMA; α-smooth muscle actin; 3â²-UTR; 3â²-untranslated region;
Growth and differentiation factor 11 (GDF11): Functions in the regulation of erythropoiesis and cardiac regeneration
Keywords: GDF11; Erythropoiesis; Cardiac regeneration; Act; activin; ActR; activin receptor type; ALK; activin receptor-like kinase; BMP; bone morphogenetic protein; BMPR; BMP receptor; CCL11; chemokine (C-C motif) ligand 11; CHF; coronary heart failure; EPO; ery
Hsp90/Cdc37 assembly modulates TGFβ receptor-II to act as a profibrotic regulator of TGFβ signaling during cardiac hypertrophy
Keywords: Hsp90; Heat shock protein 90; Cdc37; Cell division cycle 37; AngII; Angiotensin II; TGFβ; Transforming growth factor β; ECM; Extracellular matrix; TβR-I; Transforming growth factor β receptor-I; TβR-II; Transforming growth factor β receptor-II; 17AA
Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing
Keywords: AAD; active adenylation domain; 4-PBA; 4-phenylbutyric acid; 6-OHDA; 6-hydroxydopamine; ABCG5/8; ATP-binding cassette sub-family G member 5/8; AD; Alzheimer's disease; AIB1; amplified in breast cancer 1; AIP4; atrophin-1 interacting protein 4; AMPA; α-
Lefty inhibits glioma growth by suppressing Nodal-activated Smad and ERK1/2 pathways
Keywords: Lefty; Nodal; Glioma; Smad; ERK1/2; Tumor;
Age-dependent and differential effects of Smad7ÎEx1 on neural progenitor cell proliferation and on neurogenesis
Keywords: Neurogenesis; Aging; Proliferation; TGF-beta signaling; Smad; Neural stem cell;
Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-β-induced phosphorylation of ERK
Keywords: VEC; valve endothelial cells; EndMT; endothelial to mesenchymal transformation; TGFβ; transforming growth factor-β; CAEC; carotid artery endothelial cells; α-SMA; α-smooth muscle actin; AT1; angiotensin II type 1 receptor; AT2; angiotensin II type 2 r
The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation
Keywords: Kidney fibrosis; Epithelial-to-mesenchymal transition; Fibroblast; Notch; TGF-β; DBZ; dibenzazepine; UUO; unilateral ureteral obstruction; NICD; Notch intracellular domain; ICN; intracellular domain of Notch; TECs; tubular epithelial cells; ECM; extracel
The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways
Keywords: TGF-beta; BMP; SMAD; Ubiquitin; DUB; Deubiquitylation;