کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336635 | 1540638 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The dietary flavonoid myricetin regulates iron homeostasis by suppressing hepcidin expression
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کلمات کلیدی
LPShepcidin antimicrobial peptideESASSMADHJVRESERKIL-6Janus kinase - کیناز جانوس ROS - ROSSTAT - آمارinterleukin-6 - اینترلوکین ۶Reticuloendothelial system - سیستم رتیکولواندوتلیالErythropoiesis-stimulating agents - عوامل تحریک کننده ی erythropoiesislipopolysaccharide - لیپوپلی ساکاریدSignal transducer and activator of transcription - مبدل سیگنال و فعال کننده رونویسیIron metabolism - متابولیسم آهنBMP - مدیریت فرایند کسب و کارMyricetin - میریستینiron-deficiency anemia - نارسایی کمبود آهنHAMP - هامپhemojuvelin - همسایهHepcidin - هپسیدین Bone morphogenetic protein - پروتئین مورفوژنیک استخوانJAK - چگونهAnemia of inflammation - کم خونی التهابextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hepcidin, a master regulator of iron homeostasis, is a promising target in treatment of iron disorders such as hemochromatosis, anemia of inflammation and iron-deficiency anemia. We previously reported that black soybean seed coat extract could inhibit hepcidin expression. Based on this finding, we performed a screen in cultured cells in order to identify the compounds in black soybeans that inhibit hepcidin expression. We found that the dietary flavonoid myricetin significantly inhibited the expression of hepcidin both in vitro and in vivo. Treating cultured cells with myricetin decreased both HAMP mRNA levels and promoter activity by reducing SMAD1/5/8 phosphorylation. This effect was observed even in the presence of bone morphogenic protein-6 (BMP6) and interleukin-6 (IL-6), two factors that stimulate hepcidin expression. Furthermore, mice that were treated with myricetin (either orally or systemically) had reduced hepatic hepcidin expression, decreased splenic iron levels and increased serum iron levels. Notably, myricetin-treated mice increased red blood cell counts and hemoglobin levels. In addition, pretreating mice with myricetin prevented LPS-induced hypoferremia. We conclude that myricetin potently inhibits hepcidin expression both in vitro and in vivo, and this effect is mediated by altering BMP/SMAD signaling. These experiments highlight the feasibility of identifying and characterizing bioactive phytochemicals to suppress hepcidin expression. These results also suggest that myricetin may represent a novel therapy for treating iron deficiency-related diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 30, April 2016, Pages 53-61
Journal: The Journal of Nutritional Biochemistry - Volume 30, April 2016, Pages 53-61
نویسندگان
Mingdao Mu, Peng An, Qian Wu, Xiaoyun Shen, Dandan Shao, Hao Wang, Yingqi Zhang, Shenshen Zhang, Hui Yao, Junxia Min, Fudi Wang,