دانلود مقالات ISI درباره صاف + ترجمه فارسی

Fingolimod treatment promotes proliferation and differentiation of oligodendrocyte progenitor cells in mice with experimental autoimmune encephalomyelitis

Keywords: صاف; MS; multiple sclerosis; CNS; central nervous system; S1P; sphingosine 1-phosphate; BBB; blood-brain barrier; OPC; oligodendrocyte progenitor cell; Shh; sonic hedgehog; Smo; smoothened; EAE; experimental autoimmune encephalomyelitis; PLP; myelin proteoli

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development

Keywords: صاف; Smoothened; Patched; Patterning; Sonic hedgehog; Apical ectodermal ridge; Mesenchyme;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Stromal Indian Hedgehog Signaling Is Required for Intestinal Adenoma Formation in Mice

Keywords: صاف; COX2; Prostaglandin; Mouse Model; Colon Cancer; α-Sma Sma; α-Sma smooth muscle actin; Bmp; bone morphogenetic protein; BrdU; bromodeoxyuridine; Cyp1a1Cre; cytochrome p450-1a1Cre; Gli1; glioma-associated oncogene; Hhip; Hedgehog-interacting protein; Ihh;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21Waf1/Cip1 mediated inhibition of Hh-Gli signaling

Keywords: صاف; MCF-10A-Tr; Curcumin; Resveratrol; Combination therapy; Hh-Gli Signaling; p21Waf/Cip1; CSC; cigarette smoke condensate; MCF-10A-Tr; Cigarette smoke condensate mediated MCF-10A transformed cells; MTT; [3-(4, 5-dimethylthiazol-2yl-)-2, 5-diphenyl tetrazoliu

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2015 سفارش ترجمه

Molecular cross talk between Notch1, Shh and Akt pathways during erythroid differentiation of K562 and HEL cell lines

Keywords: صاف; NICD; Notch1 intracellular domain; Shh; Sonic Hedgehog; GSI; Gamma secretase inhibitor; DNCSL; Dominant negative CSL; Ptch1; Patched1; Smo; Smoothened; myr-Akt; myristoylated-Akt; Gli; Glioma-associated oncogene homologue; Notch1; Erythropoiesis; Shh; Akt

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells

Keywords: صاف; T-ALL; GLI1; GANT58; AKT inhibitor; Apoptosis; Hh; hedgehog; T-ALL; acute T cell leukemia; SMO; Smoothened; GLI1; GLI family zinc finger 1; SHH; Sonic hedgehog; DHH; Desert hedgehog; IHH; Indian hedgehog; PTCH1; Patched 1; PI3K; phosphatidylinositol 3-kin

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Arsenic inhibits hedgehog signaling during P19 cell differentiation

Keywords: صاف; Shh; sonic hedgehog; PTCH; patched; SMO; smoothened; SUFU; suppressor of fused; Bmp; bone morphogenetic protein; Fgf; fibroblast growth factor; Gsk3β; glycogen synthase kinase 3β; Arsenic; P19 cells; Stem cells; Sonic hedgehog; Gli2; Cell differentiatio

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Protein kinase inhibitor SU6668 attenuates positive regulation of Gli proteins in cancer and multipotent progenitor cells

Keywords: صاف; AP; alkaline phosphatase; ASCs; adipose tissue derived stromal cells; GliACT; transcriptional activator form of Gli proteins; GliFL; full-length Gli proteins; Ptch; patched; RNAi; RNA interference; Shh; Sonic Hedgehog; Smo; Smoothened; shRNA; short hairpi

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA

Keywords: صاف; 7-TM; seven transmembrane domain; AC; adenylate cyclase; AKAP; A-kinase anchoring protein; Bnz-cAMP; N6-benzoyl-cAMP; 8-CPT; 8-CPT-2-Me-cAMPS; cGCPs; cerebellar granule cell progenitors; IBMX; isobutylmethylxanthine; FSK; forskolin; GliA; Gli activator; G

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Modulation of the Wnt/beta-catenin pathway in human oligodendroglioma cells by Sox17 regulates proliferation and differentiation

Keywords: صاف; HOG; human oligodendroglioma; ODGs; oligodendrogliomas; OPCs; oligodendrocyte progenitor cells; Shh; sonic hedgehog; SFRP1; secreted frizzled related protein; Sox17; SRY-Box containing gene 17; CNPase; 2′,3′-cyclic-nucleotide 3′-phosphodiesterase; M

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO

Keywords: صاف; Hedgehog pathway; Smoothened; Patched; Amide isosteres; p38; Heterocycles

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling

Keywords: صاف; Smo; smoothened; Hh; hedgehog; Ptc; patched; Shh; sonic hedgehog; β arr2; β-arrestin2; β arr2-GFP; β-arrestin2-green fluorescent protein chimera; Gli; glioma-associated oncogene; GPCR; G-protein-coupled receptor; V2R; vasopressin2 receptor; HTS; high-

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Drosophila miR-5 suppresses Hedgehog signaling by directly targeting Smoothened

Keywords: صاف; miR-5; Hedgehog; Drosophila; Smoothened

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish

Keywords: صاف; Zebrafish; Heart; Endocardium; Hedgehog; Fibronectin; NFATc1; Endoderm; Cyclopamine; Smoothened; Notochord;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma

Keywords: صاف; Hedgehog signaling; Sarcoma; Smoothened; Patched; Chondrosarcoma; Vismodegib

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism

Keywords: صاف; Mouse Model; Liver Disease; Signal Transduction; Gene Regulation; α-SMA; α-smooth muscle actin; BDL; bile duct ligation; 2DG; 2-deoxy-glucose; DTG; double-transgenic; FBP; fructose bisphosphatase; GFP; green fluorescent protein; GLI; glioblastoma; Hh;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit

Keywords: صاف; Smoothened; Hedgehog; Amide replacement;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Expression of hedgehog signaling molecules in lung cancer

Keywords: صاف; Hedgehog pathway; Lung cancer; Smoothened; Rab23; PDGFRα; Hedgehog interacting protein

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Hedgehog signaling in skin cancers

Keywords: صاف; Hedgehog; Smoothened; PTCH1; Skin cancer; Signal transduction; Therapy

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines

Keywords: صاف; Hedgehog; Smoothened; Hh; SMO; Cancer; Oncology;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Gli2 Expression and Human Bladder Transitional Carcinoma Cell Invasiveness

Keywords: صاف; urinary bladder neoplasms; carcinoma, transitional cell; gene expression; cyclopamine; Gli2 protein; EMT; epithelial-to-mesenchymal transition; EtOH; ethanol; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Hh; hedgehog; IHH; Indian Hh; Ptch; Patched; qP

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling

Keywords: صاف; Hedgehog; Wnt; Mouse; Apc; Smoothened; Intestine; Stem cell; Tumor

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Sonic hedgehog signaling regulates actin cytoskeleton via Tiam1-Rac1 cascade during spine formation

Keywords: صاف; Sonic hedgehog; Smoothened; Tiam1; Dendritic spine; Actin;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Regulation of Smoothened by Drosophila G-protein-coupled receptor kinases

Keywords: صاف; Hedgehog signaling; G-protein-coupled receptor kinase; Protein trafficking; Patched; Smoothened; Drosophila melanogaster;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain

Keywords: صاف; Sonic hedgehog; Smoothened; Conditional knock-out; Optic cup; Proliferation; Cell death; BMP4; Pax2/6; Vax1/2; Fgf15

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations

Keywords: صاف; Hedgehog; GLI; Smoothened; Cancer; Small molecule

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

Keywords: صاف; Cilia; Gli; Hh signaling; IFT88; Smoothened; Sufu

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Trafficking, development and hedgehog

Keywords: صاف; Hedgehog signaling; Trafficking; Rab23; Cilia; Intraflagellar transport; Patched; Smoothened; Gli; Sterols

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Hedgehog signaling patterns mesoderm in the sea urchin

Keywords: صاف; Hedgehog; Patched; Smoothened; Morphogenesis; Endoderm; Mesoderm; Signal transduction;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2009 سفارش ترجمه

Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent

Keywords: صاف; Primordial germ cell; Zebrafish; Hedgehog signaling; Smoothened; Cyclopamine;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila

Keywords: صاف; Patched; Smoothened; Tow; Hedgehog; Signalling; Development; Wing disc; Drosophila; Lipophorin

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Depletion of the Colonic Epithelial Precursor Cell Compartment Upon Conditional Activation of the Hedgehog Pathway

Keywords: صاف; Bmp; bone morphogenetic protein; Hh; Hedgehog; Ihh; Indian hedgehog; PCR; polymerase chain reaction; Ptch; Patched; Shh; Sonic hedgehog; Smo; Smoothened;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2009 سفارش ترجمه

Disp1 regulates growth of mammalian long bones through the control of Ihh distribution

Keywords: صاف; Disp1; Dispatched1; Ihh; Indian hedgehog; N-Shh; non-cholesterol modified Sonic hedgehog; PTHrP; parathyroid hormone related peptide; Shh; sonic hedgehog; Ptch1; Patched1; Smo; Smoothened; PPR; Parathyroid hormone-PTHrP receptor; Disp2; Dispatched2; Disp1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

The decoupling of Smoothened from Gαi proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning

Keywords: صاف; Hedgehog; Smoothened; G protein; Gli3; Neural tube

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

Keywords: صاف; Sonic hedgehog; FKBP8; Gli2; Kif3a; Smoothened; Mouse; Chimera; Neural tube patterning

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

The cell biology of Smo signalling and its relationships with GPCRs

Keywords: صاف; Hh signalling; Smoothened; GPCR; GRKs; β-arrestin

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway

Keywords: صاف; Hedgehog; Smoothened; GPCR; Fused; Signaling; Imaginal disc; Clone 8 cells; Drosophila development; Two hybrid; Fluorescent imaging

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

Expression patterns of Hedgehog signalling pathway members during mouse palate development

Keywords: صاف; Hedgehog; Palate; Development; Expression; Shh; Ihh; Patched1; Patched2; Smoothened; Gli1; Gli2; Gli3; Dispatched1; Gas1; Rab23

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Hedgehog signaling in small-cell lung cancer: Frequent in vivo but a rare event in vitro

Keywords: صاف; Small-cell lung cancer; SCLC; Hedgehog signaling pathway; Cyclopamine; siRNA; HH; hedgehog; HHIP; hedgehog interacting protein; NSCLC; non-SCLC; PTCH; Patched; RNAi; RNA interference; SCLC; small-cell lung cancer; SHH; Sonic hedgehog; siRNA; small interfe

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Mouse Rab23 regulates Hedgehog signaling from Smoothened to Gli proteins

Keywords: صاف; Sonic Hedgehog; Rab23; Smoothened; Gli2; Gli3; Neural tube; Patterning

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened

Keywords: صاف; Clathrin; Endosomes; Hedgehog signaling; Patched; Skeletal muscle; Smoothened; Zebrafish

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2006 سفارش ترجمه

smoothened, thickveins and the genetic control of cell cycle and cell fate in the developing Drosophila eye

Keywords: صاف; Smoothened; Hedgehog; Thickveins; Decapentaplegic; Compound eye; Morphogenetic furrow; Cell cycle

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2006 سفارش ترجمه

Human receptor Smoothened, a mediator of Hedgehog signalling, expressed in its native conformation in yeast

Keywords: صاف; Hh; Hedgehog; hSmo; human Smoothened; Ptc; Patched; AOX1; alcohol oxidase 1; PMSF; phenylmethylsulfonyl fluoride; EGTA; ethylene glycol bis(β-aminoethyl ether); CBD; calmodulin binding domain; HA; hemagglutinin A; PCR; polymerase chain reaction; SDS-PA

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Hedgehog signaling pathway as a therapeutic target in breast cancer

Keywords: صاف; Hedgehog ligands; Sonic hedgehog; Patched1; Smoothened; Glis; Cyclopamine; Mammary gland; 5-E1 antibody;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Sonic hedgehog signaling in basal cell carcinomas

Keywords: صاف; Basal cell carcinoma; Ultraviolet; Mutation; Sonic hedgehog; Patched; Smoothened; BCC, basal cell carcinoma; SHH, sonic hedgehog; PTCH, patched; SMO, smoothened; HIP, hedgehog interacting protein; NBCC, nevoid basal cell carcinoma; XP, xeroderma pigmentos

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

Keywords: صاف; Primary cilia; Smoothened; Shh; Gli cortical patterning;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment

Keywords: صاف; Morphogen gradient; Hedgehog accretion and internalization; Serrate; Patched; Smoothened; Dynamin; Rab-7; Trafficking;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

The Hedgehog Signalling Pathway in the Gastrointestinal Tract: Implications for Development, Homeostasis, and Disease

Keywords: صاف; Dhh; Desert hedgehog; EA/TEF; esophageal atresia/tracheo-esophageal fistula; Hh; hedgehog; HIP; hedgehog-interacting protein; Ihh; Indian hedgehog; N-Hhp; processed hedgehog; Ptc; patched; Smo; smoothened; Shh; Sonic hedgehog;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه