Keywords: Biocompatible; Cytotoxicity; Graphene; Nanocarrier; SN-38;
مقالات ISI (ترجمه نشده)
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Keywords: Irinotecan; Diet; NAFLD; Diarrhea; Steatosis; SN-38; Lard;
Keywords: PXR; Pregnane X receptor; LPS; Lipopolysaccharide; TLR4; Toll-like receptor 4; DMETs; Drug metabolizing enzymes and transporters; CES; Carboxylesterase; CYP; Cytochrome P450; SN-38; 7-Ethyl-10-hydroxycamptothecin; SN-38G; SN-38 glucuronide; UGT1A1; Uridin
Keywords: GFN; graphene family nanomaterials; GO; graphene oxide; rGO; reduced graphene oxide; TLR4; toll-like receptor 4; PEG; polyethylene glycol; CPT; camptothecin; SN-38; 7-ethyl-10-hydroxy camptothecin; PNIPAM; poly N-isopropyl acrylamide; NGO; nano graphene o
Keywords: CPT-11; irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin; SN-38; irinotecan metabolite, ethyl-10-hydroxy-camptothecin; DSC; Differential Scanning Calorimetry; P; partition coefficient; DSPC; l-α-Distearoyl-phospathidylcholin
Food-drug interactions involving multiple mechanisms: A case study with effect of Capsaicin on the pharmacokinetics of Irinotecan and its main metabolites in rat
Keywords: APC; 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxy-camptothecin; AUC; Area under the plasma concentration-time curve; CAP; Capsaicin; CES; Carboxylesterase; CPT; Camptothecin; CPT-11; Irinotecan; CYP; cytochrome P450; DMEs; Drug-meta
Practical fluorimetric assay for the detection of anticancer drug SN-38 in human plasma
Keywords: Irinotecan; SN-38; Therapeutic drug monitoring; Fluorescence; Anticancer drugs; Diagnostics; Oncology;
Determination of irinotecan and its metabolite SN-38 in dried blood spots using high-performance liquid-chromatography with fluorescence detection
Keywords: Irinotecan; SN-38; Dried blood spots; High-performance liquid chromatography; Fluorescence detection; Therapeutic drug monitoring;
Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers
Keywords: Nanomedicine; Irinotecan; SN-38; Dendrimer; Colorectal cancer; Drug delivery; Therapeutic index;
Synthesis and biological evaluation of hypoxia-activated prodrugs of SN-38
Keywords: Hypoxia-activated prodrug; SN-38; 2-Nitroimidazole;
Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE
Keywords: Camptothecin (PubChem CID: 24360); SN-38 (PubChem CID: 104842); Irinotecan (PubChem CID: 60838); Sorafenib (PubChem CID: 216239); Topotecan (PubChem CID: 60700); FUBP1; AlphaScreen; Camptothecin; SN-38; HCC;
CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk
Keywords: CRC; Colorectal cancer; CQ; chloroquine; 3-MA; 3-methyladenine; ROS; reactive oxygen species; LMP; lysosomal membrane potential; âÏm; mitochondrial membrane potential; NAC; N-acetyl-L-cysteine; Vit-C; vitamin C; DMSO; dimethyl sulfoxide; Pep-A; pepstat
Development and validation of an UPLC-MS/MS method for the quantification of irinotecan, SN-38 and SN-38 glucuronide in plasma, urine, feces, liver and kidney: Application to a pharmacokinetic study of irinotecan in rats
Keywords: Irinotecan; SN-38; Pharmacokinetics; UPLC-MS/MS; SN-38 glucuronide;
SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery
Keywords: Local chemotherapy delivery; SN-38; Poly(lactic acid) electrospun nanofibers; Pediatric solid tumor; Pharmacokinetics; Microdialysis
A theranostic micelleplex co-delivering SN-38 and VEGF siRNA for colorectal cancer therapy
Keywords: Micelles; Micelleplex; SN-38; VEGF siRNA; MRI; Colorectal cancer
Impact of obesity on accumulation of the toxic irinotecan metabolite, SN-38, in mice
Keywords: Obesity; Ugt1a1; SN-38; Irinotecan; Colorectal cancer; Chemotherapy; Pharmacokinetics;
Synthesis, characterization and targeting chemotherapy for ovarian cancer of trastuzumab-SN-38 conjugates
Keywords: ADCs; antibody-drug conjugates; DAR; drug-to-antibody ratio; SALCL; systemic anaplastic large cell lymphoma; LC/MS/MS; liquid chromatography tandem mass spectrometry; DIC; N,Nâ²-diisopropylcarbodiimide; DCC; dicyclohexylcarbodiimide; DCM; dichloromethane
Functional-segregated coumarin-containing telodendrimer nanocarriers for efficient delivery of SN-38 for colon cancer treatment
Keywords: Micelles; Irinotecan; SN-38; Drug delivery; Nanomedicine
Protein corona hampers targeting potential of MUC1 aptamer functionalized SN-38 core-shell nanoparticles
Keywords: SN-38; Hyaluronic acid; MUC1 aptamer; Nanoparticle; Protein corona;
Development and validation of an ultra-high performance LC–MS/MS assay for intracellular SN-38 in human solid tumour cell lines: Comparison with a validated HPLC-fluorescence method
Keywords: SN-38; Ultra-high performance LC–MS/MS; HPLC-fluorescence; Method validation; Method comparison
Determination of irinotecan and its metabolite SN-38 in rabbit plasma and tumors using a validated method of tandem mass spectrometry coupled with liquid chromatography
Keywords: CPT, camptothecin; CPT-11, irinotecan; CV, coefficient of variation; IS, internal standard; LLE, liquid-liquid extraction; MRM, multiple reaction monitoring; SD, standard deviationIrinotecan; SN-38; Camptothecin; Rabbit; VX2 tumor; LC–MS/MS
Cell diameter measurements obtained with a handheld cell counter could be used as a surrogate marker of G2/M arrest and apoptosis in colon cancer cell lines exposed to SN-38
Keywords: MTT; 3-[4,5- dimethylthiazol-2-yl],5-diphenyltetrazoliumbromide; BrdU; 5-bromo-2â²-deoxyuridine; WST; water soluble tetrazolium salt; NAD(P)H; nicotinamide adenine dinucleotide (phosphate); PI; propidium iodide; CV; coefficients of variation; MSI; micros
Fabrication of biodegradable micelles with sheddable poly(ethylene glycol) shells as the carrier of 7-ethyl-10-hydroxy-camptothecin
Keywords: Micelle; SN-38; Reduction-triggered drug release; Stability; Solubility; Cytotoxicity
A new UPLC-MS/MS method for the determination of irinotecan and 7-ethyl-10-hydroxycamptothecin (SN-38) in mice: Application to plasma and brain pharmacokinetics
Keywords: Irinotecan; SN-38; LC–MS/MS; Pharmacokinetics; Brain distribution; Carboxylesterase
Preparation and in vitro characterization of SN-38-loaded, self-forming polymeric depots as an injectable drug delivery system
Keywords: biodegradable polymers; cancer; controlled release; depot; site-specific delivery; SN-38;
Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38
Keywords: SN-38; Nanoparticle; PLGA; Pegylation; Folate targeting; Biodistribution; Nanotechnology
Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect
Keywords: Drug delivery system; EPR effect; NK012; SN-38; Clinical trial
Pharmacokinetics of SN2310, an Injectable Emulsion that Incorporates a New Derivative of SN-38 in Patients with Advanced solid Tumors
Keywords: pharmacokinetics; metabolite; clearance; prodrug; SN2310; SN-38; SN-38G; camptothecin;
Cytotoxicity and Topo I targeting activity of substituted 10--nitrogenous heterocyclic aromatic group derivatives of SN-38
Keywords: SN-38; Derivatives; Cytotoxicity; Topo I inhibitionTopoisomerase I, Topo I; camptothecin, CPT
Preparation and in vitro evaluation of actively targetable nanoparticles for SN-38 delivery against HT-29 cell lines
Keywords: Folate targeting; Nanoparticles; Nanotechnology; PLGA; SN-38
Effect of erythropoietin, 5-fluorouracil and SN-38 on the growth of DLD-1 cells
Keywords: erythropoietin; 5-fluorouracil; SN-38; colon cancer cells
Inhibition of Akt signaling by SN-38 induces apoptosis in cervical cancer
Keywords: SN-38; Cervical cancer; p53; Akt1
Molecular changes to HeLa cells on continuous exposure to SN-38, an active metabolite of irinotecan hydrochloride
Keywords: SN-38; Irinotecan; Multidrug resistance; ABCG2/BCRP; HeLa cell
Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles
Keywords: Star-shaped copolymer; Micelle; Photodynamic therapy; SN-38; Chemotherapy; Colon cancer
Food–drug interaction of (−)-epigallocatechin-3-gallate on the pharmacokinetics of irinotecan and the metabolite SN-38
Keywords: Biliary elimination; (−)-Epigallocatechin-3-gallate (EGCG); Food–drug interaction; SN-38
Importance of UDP-glucuronosyltransferase 1A1â6 for irinotecan toxicities in Japanese cancer patients
Keywords: UGT1A1; Pharmacogenetics; Irinotecan; SN-38;
Development and validation of reversed phase liquid chromatographic method utilizing ultraviolet detection for quantification of irinotecan (CPT-11) and its active metabolite, SN-38, in rat plasma and bile samples: Application to pharmacokinetic studies
Keywords: Irinotecan (CPT-11); SN-38; Plasma; Bile; Ultraviolet detection; Pharmacokinetics
Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: Possible contribution of P-glycoprotein
Keywords: Irinotecan (CPT-11); Quercetin; SN-38; P-glycoprotein; Caco-2; Pharmacokinetics
Simultaneous determination of irinotecan (CPT-11) and SN-38 in tissue culture media and cancer cells by high performance liquid chromatography: Application to cellular metabolism and accumulation studies
Keywords: CPT-11; SN-38; Metabolism; Accumulation; HPLC
HPLC method for determination of SN-38 content and SN-38 entrapment efficiency in a novel liposome-based formulation, LE-SN38
Keywords: HPLC; SN-38; Liposomes; Validation; Entrapment efficiency
Effects of different combinations of gefitinib and irinotecan in lung cancer cell lines expressing wild or deletional EGFR
Keywords: Gefitinib; CPT-11; SN-38; EGFR; Combination; Lung cancer
Pharmacogenetics of irinotecan metabolism and transport: An update
Keywords: CPT-11; SN-38; CYP3A; CES; UGT1A; ABCB1; ABCC1; ABCC2; ABCG2
Liquid chromatographic-tandem mass spectrometric assay for the simultaneous quantification of Camptosar® and its metabolite SN-38 in mouse plasma and tissues
Keywords: Liquid chromatography; Tandem mass spectrometry; Camptothecin; CPT-11; SN-38; Pharmacokinetics; Mice;
Liposomalization of SN-38 as active metabolite of CPT-11
Keywords: SN-38; ethyl-10-hydroxy-camptothecin; PEG; polyethyleneglycol; RES; reticuloendothelial system; DSPC; l-α-distearoylphosphatidylcholine; DSPG; l-α-distearoylphosphatidyl-dl-glycerol; PEG-DSG; 1-monomethoxypolyethylene-glycol-2,3-distearoylglycerol; SN-L
pH-dependent association of SN-38 with lipid bilayers of a novel liposomal formulation
Keywords: SN-38; Liposomes; Lyophilization; Bilayer; Interaction; Fluorescence; Anisotropy;
A simple and sensitive LC/MS/MS assay for 7-ethyl-10-hydroxycamptothecin (SN-38) in mouse plasma and tissues: application to pharmacokinetic study of liposome entrapped SN-38 (LE-SN38)
Keywords: Camptothecin; SN-38; Liposome; LC/MS/MS; Pharmacokinetics; Mice;
MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (β-d-glucuronate)
Keywords: ABC transporter; ATP-binding cassette transporter; ACNU; 3-[(4-amino-2-methyl-5-pyrimidinyl) methyl]-1-(2-chloroethyl)-1-nitrosourea; ADM; adriamycin; AG-A; agosterol A; azidoAG-A; [125I] 11-azidophenyl agosterol A; AZT; azidothymidine; BSO; buthionine su
Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition
Keywords: ABC; ATP binding cassette; ABCP; placenta specific ABC transporter; BCRP; breast cancer resistance protein; β-gal.; β-galactosidase; Hst; Hoechst 33342; MDR1; human multidrug resistance protein (P-glycoprotein, ABCB1); MRP; human multidrug resistance as