کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10612668 986648 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization and targeting chemotherapy for ovarian cancer of trastuzumab-SN-38 conjugates
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Synthesis, characterization and targeting chemotherapy for ovarian cancer of trastuzumab-SN-38 conjugates
چکیده انگلیسی
Schematic displays the structures of three HER2-targeting antibody-drug conjugates (ADCs): T-SN38 A, T-SN38 B and T-SN38 C. T-SN38 A prepared with the hydrophobic ester linkage linker A which contained ester bond cleavage site; T-SN38 B contains hydrophobic linker B with carbonate cleavage site; T-SN38 C contains linker C with hydrophilic PEG4 fragment and carbonate cleavage site. Results of in vitro and in vivo showed T-SN38 A, B and C (Drug Antibody Rate, DAR = 3.7, 3.2, 3.4) have great potential for HER2-positive ovarian cancer.171
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 220, Part A, 28 December 2015, Pages 5-17
نویسندگان
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