Keywords: PC12 cells; Rat adrenal pheochromocytoma cells; SNCA; α-synuclein; pDNA; plasmid DNA; BBB; blood-brain barrier; GNP; gold nanoparticles; CTS; chitosan; DTPA; 3,3â²-dithiodipropionic acid; NHS; N-hydroxysuccinimide; DTSP; dithiobis-(succinimidyl propio
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Synthesis, characterization, and application of a novel multifunctional stationary phase for hydrophilic interaction/reversed phase mixed-mode chromatography
Keywords: HPLC; High-Performance Liquid Chromatography; RPLC; Reversed-Phase Liquid Chromatography; HILIC; Hydrophilic Interaction Liquid Chromatography; DCC; Dicyclohexylcarbodiimide; HOBT; 1-Hydroxybenzotriazole hydrate; DCM; Dichloromethane; H; Hexane; EtOAc; Et
Keywords: Polyoxometalates; Supramolecular assembly; Dicyclohexylcarbodiimide; Bulky molecule; Molecular machine;
Keywords: AA; adipic acid; AcA; acrylic acid; AIBN; α,αâ²-azoisobutyronitrile; AM; additive manufacturing; BM; 4,4-bismaleimidodiphenylmethane; BMP; butyl-3-mercapto propionate; BPO; benzoyl peroxide; BOD; biochemical oxygen demand; CA; Candida Antarctica; CAD;
Keywords: 5-Lipoxygenase inhibitor; Inflammation; Triazole; Polyphenol; Caffeic acid; Zileuton; 5-LO; 5-Lipoxygenase; LT; Leukotriene; AA; Arachidonic Acid; SAR; Structure-Activity Relationship; CuAAC; Copper(I)-catalysed Azide Alkyne Cycloaddition; DCC; Dicyclohex
Keywords: DCC; dicyclohexylcarbodiimide; DCU; dicyclohexylurea; DEG; diethylene glycol; DMAP; 4 (N,N-dimethylamino)pyridine; EDA; 1,2-ethylenediamine; EEDQ; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; LCA; lithocholic acid; OES-LCA; oligoester of diethylene gly
Keywords: AcOEt; ethyl acetate; Boc; tert-butoxycarbonyl; Boc2O; Boc anhydride; DCC; dicyclohexylcarbodiimide; DIAD; diisopropylazodicarboxylate; DMAP; 4-(N,N-dimethylamino)pyridine; DMF; N,N-dimethylformamide; PPh3; triphenylphosphine; tBu; tert-butyl; TEA; trieth
Keywords: DAPI; 4â²,6-diamidino-2-phenylindole; DCC; dicyclohexylcarbodiimide; EDC; N-(3-dimethylaminopropyl)-Nâ²-ethyl-carbodiimide; FITC; fluorescein isothiocyanate; NBT/BCIP; nitro-blue tetrazolium chloride and 5-bromo-4-chloro-3â²-indolyphosphate p-toluidine
N-acetylcysteine modified hyaluronic acid-paclitaxel conjugate for efficient oral chemotherapy through mucosal bioadhesion ability
Keywords: HA; hyaluronic acid; PTX; paclitaxel; NAC; N-acetylcysteine; DCC; dicyclohexylcarbodiimide; DMAP; 4-dimethylaminopyridine; DMF; N,N-dimethylformamide; NAC-HA-PTX; NAC modified HA-PTX; CMC; critical micelle concentration; C6; coumarin 6; DS; the degree of
Structure-activity relationships of rationally designed AMACR 1A inhibitors
Keywords: α-Methylacyl-CoA racemase (AMACR, P504S); Drug lipophilicity; Enzyme inhibitors; Rational drug design; Structure-activity relationships; AMACR; α-methylacyl-CoA racemase; CDI; carbonyldiimidazole; DAST; (Diethylamino)sulfur trifluoride; DCC; Dicyclohexy
New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8
Keywords: Cysteine protease; Inhibitor; Aziridine; Rhodesain; Cruzain; Leishmania; DCC; Dicyclohexylcarbodiimide; DMAP; 4-(Dimethylamino)pyridine; DPSI; (S,S)-Diphenylsulfimine; GB/VI methodology; Generalized Born/Volume Integral methodology; LE; ligand efficiency;
Impact of surface grafting density of PEG macromolecules on dually fluorescent silica nanoparticles used for the in vivo imaging of subcutaneous tumors
Keywords: NPs; nanoparticles; EPR; enhanced permeation and retention effect; i.v.; intravenous; RES; reticuloendothelial system; PEG; polyethylene glycol; FRI; fluorescence reflectance imaging; NIR; near infra-red; TEOS; Tetraethyl orthosilicate; MPS; (3-mercaptopr
Structural requirements of acylated Gly-l-Ala-d-Glu analogs for activation of the innate immune receptor NOD2
Keywords: Muramyl dipeptide; Immunomodulator; Desmuramylpeptide; NOD2 agonist; Immunostimulant; Immunoadjuvant; CARD; caspase activation and recruitment domain; DCC; dicyclohexylcarbodiimide; DMAP; 4-dimethylaminopyridine; EDC; 1-ethyl-3-(3-dimethylaminopropyl)carb
Poly(lactic acid) based hydrogels
Keywords: PLA; poly(lactic acid); PDLA; poly(D-lactic acid); PLLA; poly(L-lactic acid); PLGA; poly(lactide-co-glycolide) or poly(D,L-lactide-co-glycolide); PEG; poly(ethylene glycol); DCC; dicyclohexylcarbodiimide; PEOz; poly (2-ethyl-2-oxazoline); EPR; enhanced pe
The chemistry of organo silanetriols
Keywords: AChE; acetylcholine esterase; AFM; atomic force microscopy; AKD; alkyl ketene dimer; APTES; 3-aminopropyltriethoxysilane; ASA; alkenyl succinic anhydride; aq.; aqueous; BDE; bond dissociation enthalpy; bpy; 4,4'-bipyridine; BSA; bovine serum albumin; CE
An update on the stereoselective synthesis of γ-amino acids
Keywords: ABO; 2,7,8-trioxabicyclo[3.2.1]octane; Ac; acetyl; ACPECA; 4-aminocyclopent-2-ene-1-carboxylic acid; AHPPA; 4-amino-3-hydroxy-5-phenylpentanoic acid; AMCP; 2-(aminomethyl)-cyclopentanecarboxylic acid; APCH; 2-(1-aminopropyl)cyclohexanecarboxylic acid; APT
Amphiphilic xanthones as a potent chemical entity of anti-mycobacterial agents with membrane-targeting properties
Keywords: Mycobacteria; Tuberculosis; Xanthone; Membrane targeting; ACN; acetonitrile; ATP; adenosine triphosphate; CFU; colony forming unit; CLSI; Clinical & Laboratory Standards Institute; CMFDA; 5-chloromethylfluorescein diacetate; CYP; cytochrome P450; CL; card
Synthesis of photoreactive ivermectin B1a derivatives and their actions on Haemonchus and Bombyx glutamate-gated chloride channels
Keywords: AVM; avermectin; DCC; dicyclohexylcarbodiimide; DIPEA; N,N-diisopropylethylamine; DMAP; 4-(dimethylamino)pyridine; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; EDC; 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide; GABA; γ-aminobutyric acid; GABAC
Synthesis of a mixed-model stationary phase derived from glutamine for HPLC separation of structurally different biologically active compounds: HILIC and reversed-phase applications
Keywords: HPLC; high-performance liquid chromatography; RPLC; reversed-phase liquid chromatography; NPLC; normal-phase liquid chromatography; HILIC; hydrophilic interaction chromatography; DCC; dicyclohexylcarbodiimide; DCM; dichloromethane; H; hexane; EtOAc; ethyl
Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides
Keywords: ADC; antibody-drug conjugate; MMAE; monomethyl-auristatin-E; PAB; p-aminobenzyloxy; mAb; monoclonal antibody; PEG; poly(ethylene glycol); MWCO; molecular weight cut-off; HPLC; high performance liquid chromatography; Q-TOF; Quadrupole-time-of-flight; RP-HP
Synthesis, characterization and targeting chemotherapy for ovarian cancer of trastuzumab-SN-38 conjugates
Keywords: ADCs; antibody-drug conjugates; DAR; drug-to-antibody ratio; SALCL; systemic anaplastic large cell lymphoma; LC/MS/MS; liquid chromatography tandem mass spectrometry; DIC; N,Nâ²-diisopropylcarbodiimide; DCC; dicyclohexylcarbodiimide; DCM; dichloromethane
Stereoselective synthesis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors
Keywords: HMG-CoA reductase inhibitors; Statins; Chiral β-hydroxy-δ-lactone; Chiral 3,5-syn-diol acid; Asymmetric synthesis; Ac; acetyl; Ar; aryl; Bn; benzyl; Bz; benzoyl; n-Bu; butyl; t-Bu; tert-butyl; CDI; 1,1â²-carbonyldiimidazole; BINOL; 1,1â²-bi-2-naphthol
Discovery and SAR studies of methionine-proline anilides as dengue virus NS2B-NS3 protease inhibitors
Keywords: HQRJJHXKCFABSI-UONOGXRCSA-N; SAR; structure and activity relationship; NS2B-NS3; nonstructural protein 2B and 3; DENV; dengue virus; Ki; inhibition constant; TFA; trifluoroacetic acid; EtOAc; ethyl acetate; DCM; dichloromethylene; EtOH; ethyl alcohol; DMA
Development of a novel amide-silica stationary phase for the reversed-phase HPLC separation of different classes of phytohormones
Keywords: HPLC; high-performance liquid chromatography; RPLC; reversed-phase liquid chromatography; NPLC; normal-phase liquid chromatography; HILIC; hydrophilic interaction chromatography; DCC; dicyclohexylcarbodiimide; DCM; dichloromethane; H; hexane; EtOAc; ethyl
Effects of mycophenolic acid-glucosamine conjugates on the base of kidney targeted drug delivery
Keywords: CKD; chronic kidney disease; MGC; mycophenolic acid-glucosamine conjugate; MPA; mycophenolic acid; LMWC; low molecular weight chitosan; MMF; mycophenolate mofetil; DMF; N,N-Dimethylformamide; DCM; dichloromethane; DCC; dicyclohexylcarbodiimide; DMAP; 4-
Rotor architecture in the yeast and bovine F1-c-ring complexes of F-ATP synthase
Keywords: yF1c10(I); crystal form I of yeast F1c10 sub-complex; yF1c10(II); crystal form II of yeast F1c10 sub-complex; yF1; yeast F1-ATPase structure; bF1c8; crystal of bovine F1c8 sub-complex; TMH; transmembrane helix; EM; electron microscopy; AMP-PNP; adenylyl-i
Tetrahedron report number 960Syntheses of cyanines: a review
Keywords: Cyanine dyes; Polymethine dyes; Squarines; Chiral cyanine dyes; Fullerenes; Cyclodextrins; BSA; bovine serum albumin; α-CD; α-cyclodextrin; DBF; di-n-butylformamide; DBHT; di-O-benzoyl hydrogen tartrate; DCC; dicyclohexylcarbodiimide; DIEA; diisopropyl
Electron-donating para-methoxy converts a benzamide-isoquinoline derivative into a highly Sigma-2 receptor selective ligand
Keywords: RT; room temperature; DCC; dicyclohexylcarbodiimide; THF; tetrahydrofuran; Ar; aromatic ring; OMe; methoxy; EtOH; ethanol; DTG; 1,3-di(2-tolyl)guanidine; [125I]-IAF; 1-N-(2â²,6â²-dimethyl-morpholino)-3-(4-azido-3-[125I]iodo-phenyl propane; Sigma-2 recep
Production of monoclonal antibodies against hop-derived (Humulus lupulus L.) prenylflavonoids and the development of immunoassays
Keywords: X; xanthohumol; IX; isoxanthohumol; 8-PN; 8-prenylnaringenin; EQ; equol; DAID; daidzein; GEN; genistein; COUM; coumestrol; END; enterodiol; ENL; enterolactone; E2; 17β-estradiol; BSA; bovine serum albumin; ELISA; enzyme-linked immunosorbent assay; ABTS;
The genus Dracunculus - A source of triacylglycerols containing odd-numbered Ï-phenyl fatty acids
Keywords: ACN; acyl carbon number; APCI; atmospheric pressure chemical ionization mass spectrometry; BHT; butylated hydroxy toluene; AG; diacylglycerol(s); DCC; dicyclohexylcarbodiimide; DMAP; 4-dimethylaminopyridine; DPPH; 2,2-diphenyl-1-picrylhydrazyl; ECN; equiv
The Barton ester free-radical reaction: a brief review of applications
Keywords: Radical reaction; Barton ester; Thiohydroxamate ester; Decarboxylation; Ac; acetyl; AIBN; 2,2â²-azobisisobutyronitrile; DCC; dicyclohexylcarbodiimide; DIPEA; diisopropylethylamine; DMAP; N,N-4-dimethylaminopyridine; DME; ethylene glycol dimethyl ether; D
Synthesis and biological evaluation of novel neamine-nucleoside conjugates potentially targeting to RNAs
Keywords: Docking; Interaction; Neamine-nucleoside; SPR; 16S RNA; Ac; acetyl; Arg; argnine; BAIB; [bis(acetoxy)-iodo]benzene; BOC; tert-butoxycarbonyl; DCC; dicyclohexylcarbodiimide; DMF; N,N-dimethyl formamide; DMSO; dimethyl sulfoxide; Eda; ethylenediamine; Et;
Tetrahedron report number 892Azobenzenes-synthesis and carbohydrate applications
Keywords: Ac; acetyl; BBCP; bis(2,2â²-bipyridyl)copper(II) permanganate; Boc; tert-butoxycarbonyl; s-Bu; sec-Butyl; t-Bu; tert-butyl; Bz; benzoyl; CAN; cerium ammonium nitrate; CD; cyclodextrin; DCC; dicyclohexylcarbodiimide; DIB; diacetoxyiodobenzene; DMF; dimeth
Preparation of oligonucleotide microarrays on modified glass using a photoreactive heterobifunctional reagent, 1-N-(maleimidohexanoyl)-6-N-(anthraquinon-2-oyl) hexanediamine (MHAHD)
Keywords: MHAHD; 1-N-(maleimidohexanoyl)-6-N-(anthraquinon-2-oyl) hexanediamine; THF; tetrahydrofuran; NHS; N-hydroxysuccinimide; DCC; dicyclohexylcarbodiimide; TLC; thin layer chromatography; NMI; N-methylimidazole; DMSO; dimethylsulfoxide; Heterobifunctional reag
ÎÏ and ÎpH are equivalent driving forces for proton transport through isolated F0 complexes of ATP synthases
Keywords: DCCD; dicyclohexylcarbodiimide; CCCP; carbonyl cyanide m-chlorophenylhydrazone; TBT; tributlytin; ATP synthase; F0 part; H+-transport; Pyranine; Driving force;
Remarkable stability of the proton translocating F1FO-ATP synthase from the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1
Keywords: BN-PAGE; Blue-native polyacrylamide gel electrophoresis; CF1FO; chloroplast ATP synthase; chl a; chlorophyll a; DCCD; dicyclohexylcarbodiimide; DDM; n-dodecyl-β-d-maltoside; ESI-MS; electrospray ionisation mass spectrometry; MALDI-TOF-MS; matrix-assisted
Synthesis of cyclonucleosides having a C-C bridge
Keywords: Ac; acetyl; AIBN; azobisisobutyronitrile (2,2â²-azobis(2-methylpropionitrile)); An; anisyl; BOM; benzyloxymethyl; Bu; butyl; Bz; benzoyl; CAN; ceric ammonium nitrate; DBU; diazadicycloundecane; DCC; dicyclohexylcarbodiimide; DMAP; 4-dimethylaminopyridine
Segment coupling to a highly hindered N-terminal, alamethicin-related α-aminoisobutyric acid (Aib) residue
Keywords: Aib; α-aminoisobutyric acid residue; Boc; tert-butyloxycarbonyl; DCC; dicyclohexylcarbodiimide; DB(DMAP); 2,6-di-t-butyl-4-(dimethylamino)pyridine; DCM; dichloromethane; DIC; N,Nâ²-diisopropylcarbodiimide; DIEA; N,N-diisopropylethylamine; DMF; N,N-dimet
Salt shock induces state II transition of the photosynthetic apparatus in dark-adapted Dunaliella salina cells
Keywords: Chl; chlorophyll; DCCD; dicyclohexylcarbodiimide; LHCII; light harvesting chlorophyll a/b binding proteins; PSI; photosystem I; PSII; photosystem II; ATP content; LHCII phosphorylation; Salt shock; State transition; Dunaliella salina;
Development of murine monoclonal antibodies to methamphetamine and methamphetamine analogues
Keywords: CNS; central nervous system; mAb; monoclonal antibody; THF; tetrahydrofuranne; Boc; Di-tert-butyl dicarbonate; TFA; trifluoroacetic acid; Pd/C; Palladium on carbon; DCC; dicyclohexylcarbodiimide; HOBt; 1-hydroxybenzotriazole; SMCC; 4-(N-maleimidomethyl)cy
A cationic cytofectin with long spacer mediates favourable transfection in transformed human epithelial cells
Keywords: BCA; bicinchoninic acid; Chol-T; 3β[N-(Nâ²,Nâ²-dimethylaminopropane)-carbamoyl] cholesterol; DCC; dicyclohexylcarbodiimide; DC-Chol; dimethyl aminoethane carbamoyl cholesterol 3β[N-(Nâ²,Nâ²-dimethylaminoethane)-carbamoyl] cholesterol; DMF; dimethylf
Synthetic applications of fluorous solid-phase extraction (F-SPE)
Keywords: Fluorous; Light fluorous; Fluorous silica gel; Fluorous solid-phase extraction (F-SPE); Reverse F-SPE; Plate-to-plate SPE; Parallel synthesis; High-throughput synthesis; Solution-phase synthesis; Separation; Reagents; Reactants; Catalysts; Chiral auxiliar
2-(Aryl)-3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT Inhibitors
Keywords: 4-thiazolidinones; HIV-RT; NNRTIs; Dicyclohexylcarbodiimide; QSAR
Synthesis and evaluation of the antitrypanosomal and antiplasmodial activities of new 4-aminobicyclo[2.2.2]octane derivatives
Keywords: 4-Aminobicyclo[2.2.2]octane derivatives; Trypanosoma b. rhodesiense; Plasmodium falciparum; In vitro assays; 4-Methylthiosemicarbazones; Aromatic esters; CC; column chromatography; CH2Cl2; dichloromethane; DCC; dicyclohexylcarbodiimide; 4-DMAP; 4-dimethyl
Synthesis and in vitro evaluation of macromolecular antitumour derivatives based on phenylenediamine mustard
Keywords: PDM; N,N-di(2-chloroethyl)-4-phenylenediamine mustard; PHEG; poly-[N-(2-hydroxyethyl)-l-glutamine]; PEG; poly(ethylene glycol); Z-; benzyloxycarbonyl-; MMC; mitomycin C; EDTA; ethylenediaminetetraacetic acid; NMR; nuclear magnetic resonance; s; singlet; b
The 2-aminoglucosamide motif improves cellular uptake and photodynamic activity of tetraphenylporphyrin
Keywords: Photodynamic therapy; Glucosylation; Porphyrin; Chlorin; Targeting; In vitro; ATP; adenosine triphosphate; Boc; tert-butoxycarbonyl; BSA; bovine serum albumin; CDCl3; chloroform-d; CH2Cl2; dichloromethane; DCC; dicyclohexylcarbodiimide; DDQ; 2,3-dichloro
The role of α-synuclein in neurodegenerative diseases
Keywords: αSp22; O-glycosylated α-synuclein; 6-OHDA; 6-hydroxydopamine; Aβ; β-amyloid; AD; Alzheimer's disease; A; adenine; Ala; alanine; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; AR-JP; autosomal recessive juvenile parkinsonism; BS3;
Acyclic α-nitro ketones: a versatile class of α-functionalized ketones in organic synthesis
Keywords: α-Nitro ketones; Acyclic; Organic synthesis; AIBN; azobisisobutyronitrile; ALA-5; δ-aminolevulinic acid; CIMP; 2-chloro-5-iodomethylpyridine; DBU; 1,8-diazobicyclo[5.4.0]undec-7-ene; DCC; dicyclohexylcarbodiimide; DHRGC; dynamic high-resolution gas chro