کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503739 1557436 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38
چکیده انگلیسی

SN-38, the active metabolite of irinotecan, poses a challenge in terms of drug delivery due to its low solubility and labile lactone ring. The aim of this study was to develop a SN-38 nanoparticulate delivery system to evaluate the in vivo blood profile and biodistribution properties of nanoparticles (NPs).Poly lactide-co-glycolide (PLGA) NPs that were covalently bound to polyethylene glycol-folate (PEG-FOL) were prepared, and their in vivo biodistribution in rats was investigated. Either the SN-38 solution or SN-38 NP suspension was administered intravenously into the tail vein at a dose of 2 mg SN-38 eq./kg. As expected, SN-38 NPs showed a higher plasma concentration in vivo when compared with free SN-38 during a 24 h period. Compared with the SN-38 solution, both folate targeted and non-targeted NPs exhibited superior drug concentration in body organs such as the liver, spleen, and lung at 1 and 8 h post-administration.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 406, Issues 1–2, 15 March 2011, Pages 122–127
نویسندگان
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