دانلود مقالات ISI درباره بیمار + ترجمه فارسی

SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signaling

Keywords: بیمار; CID; ZAP70; SYK; TCR signaling; TREC newborn screening; Live vaccine adverse event;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Borrelia-induced cytokine production is mediated by spleen tyrosine kinase (Syk) but is Dectin-1 and Dectin-2 independent

Keywords: بیمار; Borrelia; Recognition; Dectin-1; Dectin-2; Syk; Cytokines

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

In vivo and in vitro anti-inflammatory activities of Persicaria chinensis methanolic extract targeting Src/Syk/NF-κB

Keywords: بیمار; Pc-ME; methanolic extract of Persicaria chinensis; HPLC; High performance liquid chromatography; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TLR; Toll-like receptors (TLR); NF-κB; nuclear factor-κB; Akt; p

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Activation of the NLRP3 inflammasome by vault nanoparticles expressing a chlamydial epitope

Keywords: بیمار; C. trachomatis; Chlamydia trachomatis; PmpG; polymorphic membrane protein G; CARD; caspase recruitment domain; MOMP; major outer membrane protein; PAMPs; pathogen associated molecular patterns; DAMPs; danger associated molecular patterns; NLR; Nod-like re

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

n-3 Polyunsaturated fatty acids inhibit Fc ε receptor I-mediated mast cell activation

Keywords: بیمار; AA; arachidonic acid; ANOVA; analysis of variance; β-hex; β-hexosaminidase; BMMC; bone marrow-derived mast cells; CCL2; chemokine (C-C motif) ligand 2; cys-LT; cysteinyl leukotrienes; DHA; docosahexaenoic acid; DNP; 2,4-dinitrophenol; DPA; docosapentaen

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Hypermethylation in gastric cancer

Keywords: بیمار; 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; ADAM23; ADAM metallopeptidase domain 23; APC; adenomatosis polyposis coli; ATP; adenosine-triphosphate; BCL6B; B-Cell CLL/Lymphoma 6, Member B; BGS; bisulfite genomic sequencing; BMP-2; bone morphoge

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer

Keywords: بیمار; SYK; Spleen tyrosine kinase; Epithelial–mesenchymal transition; Protein phosphorylation; Signal transduction; Apoptosis

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors

Keywords: بیمار; Innate immunity; C-type lectin receptors; Myeloid cells; BDCA; blood DC antigen; CEACAM; carcinoembryonic antigen-related cell adhesion molecule; CLR; C-type lectin receptor; CTL; cytotoxic T lymphocyte; CTLD; C-type lectin domain; DAMP; damage-associated

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Interferon-α induces altered transitional B cell signaling and function in Systemic Lupus Erythematosus

Keywords: بیمار; Lupus; B cell; SYK; Hyper-responsive; Interferon-alphaAbs, antibodies; SLE, Systemic Lupus Erythematosus; BCR, B cell receptor; IFN, interferon; p-, phospho-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Cell type-specific differences in β-glucan recognition and signalling in porcine innate immune cells

Keywords: بیمار; CR3; complement receptor 3; ROS; reactive oxygen species; FAK; focal adhesion kinase; Syk; spleen tyrosine kinase; MAMPs; microorganism-associated molecular patterns; DCs; dendritic cells; LAL; limulus amebocyte lysate; mAbs; monoclonal antibodies; MDM; m

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Down-regulation of mir-542-3p promotes neointimal formation in the aging rat

Keywords: بیمار; MicroRNA; Vascular smooth muscle cells; Proliferation; Aging; Syk

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

CXCL12 and ADAM23 hypermethylation are associated with advanced breast cancers

Keywords: بیمار; ADAM23; disintegrin and metalloprotease domain 23; APC; adenomatous polyposis coli; BC; breast cancer; BRMS1; breast cancer metastasis suppressor 1; CDH1; cadherin 1, type 1; cfDNA; cell-free DNA; CMI; cumulative methylation index; CXCL12; chemokine C-X-C

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6

Keywords: بیمار; Bd-EE; Boerhavia diffusa L. ethanol extract; HPLC; high performance liquid chromatography; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TLR; Toll-like receptor (TLR); NF-κB; nuclear factor-κB; AP-1; Activat

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Epstein-Barr virus Latent Membrane Protein 2A (LMP2A)-mediated changes in Fas expression and Fas-dependent apoptosis: Role of Lyn/Syk activation

Keywords: بیمار; B cells; Epstein-Barr virus; Latency Membrane Protein 2A (LMP2A); B cell receptor (BCR); Lyn; Syk; Fas (CD95); Apoptosis; PARP;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2015 سفارش ترجمه

A critical role for the regulation of Syk from agglutination to aggregation in human platelets

Keywords: بیمار; Agglucetin; Convulxin; Glycoprotein Ibα; Integrin αIIbβ3; Syk; ADAP; adhesion and degranulation promoting adapter protein; FcRγ; Fc receptor γ-chain; FITC; fluorescein isothiocyanate; GP; glycoprotein; LAT; linker for activation of T-cells; mAb; mono

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Blockade of Syk ameliorates the development of murine sclerodermatous chronic graft-versus-host disease

Keywords: بیمار; Syk; Chronic GVHD; Systemic sclerosis; CXCR4; Memory T cells

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets

Keywords: بیمار; Ginkgolide B; Platelets; Syk; p38MAPK; PF4; CD40L;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

The Toll-like receptor 2/1 (TLR2/1) complex initiates human platelet activation via the src/Syk/LAT/PLCγ2 signalling cascade

Keywords: بیمار; Human platelets; TLR2; Pam3CSK4; Syk; LAT; PLCγ2;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

(5-Hydroxy-4-oxo-4H-pyran-2-yl)methyl 6-hydroxynaphthalene-2-carboxylate, a kojic acid derivative, inhibits inflammatory mediator production via the suppression of Syk/Src and NF-κB activation

Keywords: بیمار; (5-Hydroxy-4-oxo-4H-pyran-2-yl)methyl 6-hydroxynaphthalene-2-carboxylate; Anti-inflammatory effect; NF-κB; Syk; Src;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1

Keywords: بیمار; Ms-EE; ethanolic extract of Myrsine seguinii; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumour necrosis factor; ERK; extracellular signal-related kinase; TLR; toll-like receptors (TLR); MAPK; mit

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: Insight into disease biology and new targeted therapies

Keywords: بیمار; Chronic lymphocytic leukemia; CLL; Microenvironment; Nurselike cells; Stromal cells; CXCR4; CXCL12; B cell receptor; BCR; SYK; BTK; PI3Kδ; Chemokines; Chemokine receptors; T cells; NK cells;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Microenvironment dependency in Chronic Lymphocytic Leukemia: The basis for new targeted therapies

Keywords: بیمار; Chronic Lymphocytic Leukemia; microenvironment; nurselike cells; stromal cells; CXCR4; CXCL12; B cell receptor; SYK; BTK; PI3Kδ

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Molecular targets on mast cells and basophils for novel therapies

Keywords: بیمار; Mast cell; basophil; mediator; receptor; signaling protein; survival protein; drug; therapy; BCL-2; B-cell lymphoma 2; BH; BCL-2 homology; Bs; Basophils; BTK; Bruton tyrosine kinase; CB; Endocannabinoid receptor; CRAC; Calcium release-activated calcium;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation

Keywords: بیمار; ROS; Syk; STAT1; CD36; Foam cell;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2014 سفارش ترجمه

Mycoepoxydiene inhibits antigen-stimulated activation of mast cells and suppresses IgE-mediated anaphylaxis in mice

Keywords: بیمار; Mycoepoxydiene; Mast cell; Passive cutaneous anaphylaxis; IgE; Syk;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Saucerneol F inhibits tumor necrosis factor-α and IL-6 production by suppressing Fyn-mediated pathways in FcεRI-mediated mast cells

Keywords: بیمار; Saucerneol F; Mouse bone marrow-derived mast cells; Proinflammatory cytokine; Transcriptional factor; Fyn; Syk;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

In vitro and in vivo anti-inflammatory effect of Rhodomyrtus tomentosa methanol extract

Keywords: بیمار; PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumour necrosis factor; ERK; extracellular signal-related kinase; TLR; Toll-like receptors (TLR); MAPK; mitogen activated protein kinase; NF-κB; nuclear fact

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Development of a metastatic fluorescent Lewis Lung carcinoma mouse model: Identification of mRNAs and microRNAs involved in tumor invasion

Keywords: بیمار; miRNA; microRNA; HGF; hepatocyte growth factor; SYK; spleen tyrosine kinase; MMP; matrix metalloproteinase; LL-Kat; Lewis Lung carcinoma Katushka; KEGG; Kyoto Encyclopedia of Genes and Genomes; FDR; False Discovery Rate; GFP; Green Fluorescent Protein; EM

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

CCN4 induces vascular cell adhesion molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion

Keywords: بیمار; CCN4; OA; VCAM-1; Syk; Integrin;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Methanol extract of Hopea odorata suppresses inflammatory responses via the direct inhibition of multiple kinases

Keywords: بیمار; PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumour necrosis factor; ERK; extracellular signal-related kinase; TLR; Toll-like receptor; MAPK; mitogen activated protein kinase; NF-κB; nuclear factor-κB;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

REVIEWSmall molecules in the treatment of systemic lupus erythematosus

Keywords: بیمار; Systemic lupus erythematosus; Kinase inhibitors; Jak; Syk; HDAC inhibitors;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells

Keywords: بیمار; Syk; Calpain; Calpastatin; PTP1B; NF-κB; Bcl-2;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Tau protein kinases: Involvement in Alzheimer's disease

Keywords: بیمار; AD; Alzheimer's disease; APP; amyloid precursor protein; Arg; Abl-related gene; SFK; Src family kinase; Aβ; β-amyloid; BBB; blood brain barrier; LD50; lethal dose 50; c-Abl; c-Abelson; Cables; c-Abl-binding adaptator protein; CaMKII; Ca2+/calmodulin-dep

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2013 سفارش ترجمه

B-lymphocyte lineage cells and the respiratory system

Keywords: بیمار; B cells; plasma cells; plasmablasts; respiratory diseases; AID; Activation-induced cytidine deaminase; APRIL; A proliferation-inducing ligand; BAFF; B cell-activating factor of the TNF family; BAL; Bronchoalveolar lavage; BCMA; B-cell maturation antigen

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2013 سفارش ترجمه

Omalizumab increases the intrinsic sensitivity of human basophils to IgE-mediated stimulation

Keywords: بیمار; Human; basophil; allergy; Fc receptors; ED50; Effective density for 50% maximum response; HR; Histamine release; HSA; Human serum albumin; IL-3R; IL-3 receptor; LTC4; Leukotriene C4; PAG; PIPES-albumin-glucose; PIPES; Piperazine-N,N′-bis(2-ethanesulfoni

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

The biological rationale and clinical efficacy of inhibition of signaling kinases in chronic lymphocytic leukemia

Keywords: بیمار; Chronic lymphocytic leukemia; Microenvironment; Signaling; BTK; Syk; PI-3 kinase

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

DJ-1 regulates mast cell activation and IgE-mediated allergic responses

Keywords: بیمار; DJ-1; reactive oxygen species; mast cells; allergy; FcεRI-mediated signals; AD; Atopic dermatitis; BMMC; Bone marrow-derived mast cell; DNP; 2,4-Dinitrophenyl; H2O2; Hydrogen peroxide; KO; Knockout; LAT; Linker for activation of T cells; MAP; Mitogen-a

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase

Keywords: بیمار; GBDUVEXHPMNVRW-UHFFFAOYSA-N; UJXIKUVGGQECLJ-UHFFFAOYSA-N; FVSUKLKFSDSIEF-UHFFFAOYSA-N; OHAIFZDRLDEOAC-UHFFFAOYSA-N; PVCKRSKEOOWVMP-UHFFFAOYSA-N; LXMWGYNOGUKODT-UHFFFAOYSA-N; CQZZZUNOWZUNNG-UHFFFAOYSA-N; YBKODNZGBUDZRA-UHFFFAOYSA-N; Itk; interleukin-2-indu

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Pyrazine-based Syk kinase inhibitors

Keywords: بیمار; Syk; 2-Aminopyrazine; LAD2

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Immunoglobulin G1 immune complex upregulates interferon-γ-induced nitric oxide production via ERK1/2 activation in murine microglia

Keywords: بیمار; CNS; central nervous system; EAE; experimental autoimmune encephalomyelitis; ERK; extracellular signal-regulated kinase; FcγR; Fcγ receptor; IC; immune complex; IgG; Immunoglobulin G; IL; interleukin; iNOS; inducible nitric oxide synthatase; L-NMMA; NG-

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets

Keywords: بیمار; FcRγ-chain; Fc receptor γ-chain; SLP-76; SH2 domain-containing leukocyte protein of 76 KDa; PLCγ2; phospholipase C γ 2; LAT; linker for activation of T cells; TxA2; thromboxane A2; Syk; spleen tyrosine kinase; RGDS; Arg-Gly-Asp-Ser; ITAM; immunorecep

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Src/NF-κB-targeted inhibition of LPS-induced macrophage activation and dextran sodium sulphate-induced colitis by Archidendron clypearia methanol extract

Keywords: بیمار; PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumor necrosis factor; ERK; extracellular signal-related kinase; TLR; Toll-like receptors (TLR); MAPK; mitogen activated protein kinase; NF-κB; nuclear facto

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2

Keywords: بیمار; Syk; Tensin2; Tyrosine phosphorylation; Signal transduction;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action

Keywords: بیمار; PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumor necrosis factor; ERK; extracellular signal-related kinase; TLR; Toll-like receptors (TLR); MAPK; mitogen activated protein kinase; NF-κB; nuclear facto

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Src and Syk are targeted to an anti-inflammatory ethanol extract of Aralia continentalis

Keywords: بیمار; PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumour necrosis factor; ERK; extracellular signal-related kinase; TLR; Toll-like receptors (TLR); MAPK; mitogen activated protein kinase; NF-κB; nuclear fact

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Methanol extract of Osbeckia stellata suppresses lipopolysaccharide- and HCl/ethanol-induced inflammatory responses by inhibiting Src/Syk and IRAK1

Keywords: بیمار; Os-ME; methanol extract of Osbeckia stellata; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TNF-α; tumor necrosis factor-alpha; ERK; extracellular signal-related kinase; TLR; toll-like receptor; MAPK; mitogen

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Arctigenin suppresses receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages

Keywords: بیمار; Arctigenin; Osteoclast differentiation; RANKL; Bone marrow macrophages; Syk;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Double-edged sword effect of biochanin to inhibit nuclear factor kappaB: Suppression of serine/threonine and tyrosine kinases

Keywords: بیمار; AP-1; activator protein 1; C3-toxin; Clostridium botulinum C3 transferase; CE; cytoplasmic extracts; Cox2; cyclooxygenase 2; ICAM; intercellular adhesion molecule; NF-κB; nuclear transcription factor kappaB; IL; interleukin; IκB; inhibitory subunit of N

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Suppression of the basophil response to allergen during treatment with omalizumab is dependent on 2 competing factors

Keywords: بیمار; Basophil; anti-IgE; peanut; spleen tyrosine kinase; IgE receptor; AUC; Area under the curve; BHR; Basophil histamine release; HSA; Human serum albumin; OFC; Oral food challenge; PAG; PIPES-albumin-glucose; PIPES; Piperazine-N,N′-bis(2-ethanesulfonic aci

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1

Keywords: بیمار; Primary immunodeficiency; innate immunity; chronic mucocutaneous candidiasis; monocytes; AIRE; Autoimmune regulator; APECED; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy; CARD9; Caspase recruitment domain-containing protein 9; CMC;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه