Keywords: شناسایی هدف; Tuberculosis; Clinical isolates; Quinoloxyacetamides; Drug discovery; Target identification;
مقالات ISI شناسایی هدف (ترجمه نشده)
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Keywords: شناسایی هدف; CDC; Centers for Disease Control and Prevention; MDR; Multi-Drug Resistance; NCBI; National Center for Biotechnology Information; BLAST; Basic Local Alignment Search Tool; DEG; Database of Essential Genes; e-value; expect value; VFDB; Virulence Factors Da
Keywords: شناسایی هدف; TAG; Triacylglycerol; HTS; high throughput screening; G3P; glycerol-3-phosphate; GPAT; acyl-CoA:glycerol-3-phosphate acyltransferase; LPA; lysophosphatidic acid; LPAAT; acyl-CoA:lysophosphatidic acid acyltransferase; PA; phosphatidic acid; PAP; Phosphatid
Keywords: شناسایی هدف; Cisplatin; Nephrotoxicity; Structure-toxicity relationship (STR); Biotin labeling; Chemical proteomics; Target identification;
Keywords: شناسایی هدف; Transient interaction; Magnetic nanoparticle; Target identification; Peroxisomal targeting signal PTS1; Pex5p;
Keywords: شناسایی هدف; Herbal medicine; Polypharmacological effects; RNA-seq; Transcriptome-based inference method; Target identification;
Keywords: شناسایی هدف; Dynamic modelling; Multi-objective optimization; Large-scale; Metabolic engineering; Target identification; Up/down-regulation;
Keywords: شناسایی هدف; Data integration; Information technologies; Target identification; Computer-aided drug discovery
Keywords: شناسایی هدف; Natural and traditional medicines; Target identification; Chemical biology; Quantitative proteomics; SILAC; iTRAQAkt, protein kinase B; CSNK1G3, casein kinase 1, gamma 3; DMSO, dimethyl sulfoxide; ICAT, isotope-coded affinity tag; iTRAQ, isobaric tag for
Keywords: شناسایی هدف; Cell migration; Autophagy; Filopodia; Lamellipodia; Target identification; 14-3-3; GLUT; VCP;
Keywords: شناسایی هدف; Bioactive small molecules; Target identification; CETSA, transcriptome sequencing; CRISPR/Cas9; Profiling; Target prediction; Chem-seq;
Keywords: شناسایی هدف; Affinity resin; Target identification; Antibodies; Photochemistry; Protein purification;
Keywords: شناسایی هدف; GIMJFXHTNOGPAM-UHFFFAOYSA-N; CKUAMXWZIHXZJC-LOSJGSFVSA-N; YBJHBAHKTGYVGT-LXZQMHNESA-N; RMZKVCKJEHAWTI-XEHMEICKSA-N; OOLVIVWLBJDLCW-UHFFFAOYSA-N; RKOKHAJYHOICFY-QFIPXVFZSA-N; BMCWUEGJCOGXTM-YANBTOMASA-N; AZEXWHKOMMASPA-UHFFFAOYSA-N; VRJGPUZOUFNEGB-UHFFFAOY
Keywords: شناسایی هدف; Chemical identification; High-resolution mass spectrometry; Mass spectral library; Mass spectrometry; Metrology; Non-target identification; Prediction of spectra; Qualitative analysis; Spectral interpretation; Target identification; B; Magnetic sector mas
Keywords: شناسایی هدف; target identification; translational medicine; multiple-component and multiple-target drugs; gut microbiota; remote target
Keywords: شناسایی هدف; HIP, haploinsufficiency profiling; HOP, homozygous profiling; MoA, mechanism of action; FAS, fatty acid synthase; Cmpd, compoundChemogenomic profiling; Target identification; Mechanism of action; Yeast; HIP HOP profiling
Keywords: شناسایی هدف; Uncertainty visualization; Decision-making; Confidence; Performance; Workload; Target identification
Virtual target screening reveals rosmarinic acid and salvianolic acid A inhibiting metallo- and serine-β-lactamases
Keywords: شناسایی هدف; Natural product; Rosmarinic acid; Salvianolic acid; Metallo-β-lactamases; Target identification;
Epoxides related to dioncoquinone B: Synthesis, activity against multiple myeloma cells, and search for the target protein
Keywords: شناسایی هدف; Epoxides; Naphthoquinones; Multiple myeloma; Target identification; Biotinylation;
Caenorhabditis elegans as a model system for target identification and drug screening against neurodegenerative diseases
Keywords: شناسایی هدف; Amyloid; Neurodegenerative diseases; Animal model; C. elegans; Drug screening; Target identification;
Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position
Keywords: شناسایی هدف; Thieno[2,3-d]pyrimidine; Dithiocarbamate; Cytotoxicity; Probe; Target identification; Tubulin; Boc; tert-butyloxycarbonyl; CPT; camptothecin; DMF; N,N-dimethylformamide; DMSO; dimethyl sulphoxide; DSB; DNA double-strand break; EDCI; 1-ethyl-3-(3-dimethyla
Proteome mining for the identification and in-silico characterization of putative drug targets of multi-drug resistant Clostridium difficile strain 630
Keywords: شناسایی هدف; Clostridium difficile; Target identification; Essential protein; Protein-protein interaction;
Evaluation of CAAX prenyl protease II of Leishmania donovani as potential drug target: Infectivity and growth of the parasite is significantly lowered after the gene knockout
Keywords: شناسایی هدف; Leishmania; Target identification; CAAX prenyl protease II; Gene knockout; Ras protein;
HMBA is a putative HSP70 activator stimulating HEXIM1 expression that is down-regulated by estrogen
Keywords: شناسایی هدف; HEXIM1; hexamethylene bis-acetamide inducible protein 1; HMBA; hexamethylene bis-acetamide; HSP70; heat shock protein 70; SAHA; suberanilohydroxamic acid; HDAC; histone deacetylases; SDS/PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; FBS
TiD: Standalone software for mining putative drug targets from bacterial proteome
Keywords: شناسایی هدف; TiD; Target iDentification; DEG; Database of Essential Genes; CEG; Cluster of Essential Genes; MDR; Multi Drug Resistant; GUI; Graphical User Interface; NCBI; National Center For Biotechnology Information; FDA; Food and Drug Administration; KEGG; Kyoto En
Original ArticleDNA-PKcs, a novel functional target of acriflavine, mediates acriflavine's p53-dependent synergistic anti-tumor efficiency with melphalan
Keywords: شناسایی هدف; Acriflavine; Target identification; DNA-PKcs; Melphalan; p53;
Target identification of covalently binding drugs by activity-based protein profiling (ABPP)
Keywords: شناسایی هدف; Covalent binding drugs; Activity based protein profiling; Target identification; Biologically active molecules; Drug targets;
Chemogenomics knowledgebase and systems pharmacology for hallucinogen target identification-Salvinorin A as a case study
Keywords: شناسایی هدف; Hallucinogen; Salvinorin A; Drug abuse; Chemogenomics database; Target identification; Systems pharmacology;
Identification and characterization of β-sitosterol target proteins
Keywords: شناسایی هدف; β-Sitosterol; 17β-HSD4; E-Syt1; Target identification; Phytosterol;
Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506
Keywords: شناسایی هدف; Affinity resins; PEG; Target identification; Carbonic anhydrase II; FKBP12; Benzenesulfonamide; FK506; Calcineurin; Target complex
Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors
Keywords: شناسایی هدف; Tamoxifen; Anticancer drug; Phage display; Target identification
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
Keywords: شناسایی هدف; Nybomycin; Antibiotic; Tuberculosis; Dormant; Target identification;
HIF-1α suppressing small molecule, LW6, inhibits cancer cell growth by binding to calcineurin b homologous protein 1
Keywords: شناسایی هدف; Angiogenesis; Calcineurin b homologous protein 1; Hypoxia-inducible factor-1α; LW6; Target identification; CHP1; calcineurin b homologous protein 1; FBS; fetal bovine serum; HIF-α; hypoxia inducible factor-1 alpha; HUVEC; human umbilical vein endothelia
Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents
Keywords: شناسایی هدف; SK; streptokinase; GAS; Group A Streptococcus; HTS; high-throughput screen; SAR; structure-activity relationship; TPSA; topological polar surface area; c Log P; logarithm of the calculated octanol-water partition coefficient; LDA; lithium diisopropy
The role of microRNAs in melanoma
Keywords: شناسایی هدف; EZH2, enhancer of zeste homolog 2; HGF, hepatocyte growth factor; MITF, microphthalmia-associated transcription factor; NHEM, normal human epidermal melanocyte; YB1, Y box binding protein 1Melanoma; MicroRNA; Expression profiling; Target identification; B
Target detection and classification by measuring and processing bistatic UWB radar signal
Keywords: شناسایی هدف; Bistatic UWB radar; Target detection; Target identification; Support vector machine; Chaos differential evolution;
Small molecule modulators of Wnt/β-catenin signaling
Keywords: شناسایی هدف; APC; adenomatous polyposis coli; CRC; colorectal cancer; Dvl; dishevelled; LEF/TCF; lymphoid enhancer factor/T cell factor; Fzd1; Frizzled1; GFP; green fluorescent protein; GSK3; glycogen synthase kinase 3; SAR; structure-activity relationships; Wnt sig
Design and interpretation of microRNA-reporter gene activity
Keywords: شناسایی هدف; miRNA; Target identification; Luciferase assay; miR-181b; Schizophrenia;
Chemical tagging of a drug target using 5-sulfonyl tetrazole
Keywords: شناسایی هدف; 5-Sulfonyl tetrazole; Chemical tagging; Bioactive small molecule; Receptor protein; Target identification
Bioanalytical strategies for in-vitro and in-vivo evaluation of the toxicity induced by metallic nanoparticles
Keywords: شناسایی هدف; Animal model; Bioanalytical strategy; Cellular uptake; Interaction mechanism; In-vitro assay; In-vivo assay; Metallic nanoparticle (MNP); Target identification; Toxicity assessment; Toxicity marker
Identification and validation of bioactive small molecule target through phenotypic screening
Keywords: شناسایی هدف; ADME; absorption, distribution, metabolism, and excretion; CsA; cyclosporin A; HBC; 4-[3,5-bis-[2-(4-hydroxy-3-methoxy-phenyl)-ethyl]-4,5-dihydro-pyrazol-1-yl]-benzoic acid; HDAC; histone deacetylase; HUVEC; human umbilical vascular endothelial cell; KF;
Identification and validation of protein targets of bioactive small molecules
Keywords: شناسایی هدف; Target identification; Target validation; Chemical biology; Small molecules; Protein targets;
Valosin containing protein (VCP) interacts with macrolide antibiotics without mediating their anti-inflammatory activities
Keywords: شناسایی هدف; Macrolide; Chemical proteomics; Target identification; Valosin containing protein; Inflammation;
Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells
Keywords: شناسایی هدف; ROBKOHOXCCIGKA-YDHLFZDLSA-N; CTIXSYGGXMDSBQ-UHFFFAOYSA-N; RXRSCJCBYDKOQS-LTDRVIOCSA-N; MVXLOAFTFDPCPK-LTDRVIOCSA-N; GTGDGIDWSMIASH-UHFFFAOYSA-N; LQLIXLQXXVQGEH-AAAIIBCSSA-N; UFXCYDLBJWLCQS-LTDRVIOCSA-N; JXTAMIXHZPMMRQ-UHFFFAOYSA-N; MFXXCQOJSTXKBJ-UHFFFAOY
Target identification of bioactive compounds
Keywords: شناسایی هدف; Target identification; Bioactive compounds; Protein function; Chemical genetics;
Proteomic identification of binding targets of isothiocyanates: A perspective on techniques
Keywords: شناسایی هدف; Isothiocyanates; Proteomics; Mass spectrometry; Target identification; Covalent modification
Selective elution of target protein from affinity resins by a simple reductant with a thiol group
Keywords: شناسایی هدف; Affinity resins; Target identification; Carbonic anhydrase II; FKBP12; Benzenesulfonamide; FK506; 2-Mercaptethanol (2ME); AquaFirmus
The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport
Keywords: شناسایی هدف; Natural products; Chemical biology; Target identification; Organic synthesis
Iodine scanning of a phenazine inhibitor of vacuolar sorting
Keywords: شناسایی هدف; Chemical genetics; Target identification; Gravitropism
Evaluation of various inverse docking schemes in multiple targets identification
Keywords: شناسایی هدف; Inverse docking; Target identification; Target database; GOLD; FlexX; TarFisDock; TarSearch-X; TarSearch-M