کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1226491 968307 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proteomic identification of binding targets of isothiocyanates: A perspective on techniques
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Proteomic identification of binding targets of isothiocyanates: A perspective on techniques
چکیده انگلیسی

Intake of cruciferous vegetable is inversely associated with the risk of several cancer types. Isothiocyanates (ITCs) are believed to be important constituents contributing to these cancer-preventive effects. Although several mechanisms, including induction of apoptosis, have been proposed for the anti-carcinogenesis activities of ITCs, detailed upstream triggering events are still not fully understood. Identification of ITC binding targets in cellular proteins is crucial for not only mechanistic studies but also future drug screening and design. In this review, we summarize recent progress in discovery of ITC protein targets from a technical perspective. The advantages and limitations of each method are discussed to facilitate future studies on target discovery of ITCs and perhaps other compounds.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Proteomics - Volume 74, Issue 7, 10 June 2011, Pages 1036–1044
نویسندگان
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