Effect of Trichostatin A on radiation induced epithelial-mesenchymal transition in A549Â cells
Keywords: Radiation; EMT; Trichostatin A; TGFβ1; Docking studies;
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TGF-β1 affects cell-cell adhesion in the heart in an NCAM1-dependent mechanism
Keywords: Heart failure; TGFβ1; Cell adhesion; NCAM1; Intercalated disc; TGFβ1; transforming growth factor beta 1; NCAM1; neural cell adhesion molecule 1; TG; transgenic mice; Dox; doxycycline; MHC; myosin heavy chain; WT; wild-type; ID; intercalated disc;
Research paperTGFβ1 synergizes with FLT3 ligand to induce chemoresistant quiescence in acute lymphoblastic leukemia with MLL gene rearrangements.
Keywords: Acute lymphoblastic leukemia; Mixed-lineage leukemia gene; FLT3 ligand; TGFβ1; Chemoresistance; Cell cycle arrest;
TGFβ1 induces endometrial cancer cell adhesion and migration by up-regulating integrin αvβ3 via SMAD-independent MEK-ERK1/2 signaling
Keywords: TGFβ1; Integrin β3; Integrin αv; Serous endometrial cancer; Type II endometrial cancer; Vitronectin;
THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro
Keywords: ACTB; β-actin; CCL2; chemokine (C-C motif) ligand 2; CCL18; chemokine (C-C motif) ligand 18; CCL22; chemokine (C-C motif) ligand 22; CCR7; chemokine (C-C motif) receptor 7; CD; cluster of differentiation; COX2; cytochrome C oxidase-2; IFNγ; interferon-Î
Chronic stress impairs the local immune response during cutaneous repair in gilthead sea bream (Sparus aurata, L.)
Keywords: COLIVα1; collagen type IV alpha 1 chain; CRTAC2; cartilage acidic protein 2; CSF-1R; colony stimulating factor 1 receptor; GR; glucocorticoid receptor; HPA; hypothalamic-pituitary-adrenal; HSI; hepatosomatic index; K; condition factor; MMC; melanomacroph
MicroRNA-146a-5p attenuates liver fibrosis by suppressing profibrogenic effects of TGFβ1 and lipopolysaccharide
Keywords: Liver fibrosis; LPS; TGFβ1; miR-146a-5p; Bambi;
Binding of coronin 1B to TβRI negatively regulates the TGFβ1 signaling pathway
Keywords: Coronin 1B; TGFβ1; TβRI; VSMCs;
Intrauterine exposure to 17β-oestradiol (E2) impairs postnatal development in both female and male prostate in gerbil
Keywords: Female prostate; Intrauterine exposure; E2; Environment; ESR1; ESR2; AR; TGFβ1; FGF10; CD34; Sex variations;
AAV-mediated gene delivery attenuates neuroinflammation in feline Sandhoff disease
Keywords: AAV; adeno-associated virus; CNS; central nervous system; DCN; deep cerebellar nuclei; GFAP; glial fibrillary acidic protein; Hex; β-N-acetylhexosaminidase; Iba1; ionized calcium-binding protein 1; ICV; intracerebroventricular; IL-1β; interleukin 1 beta
BMP7-induced-Pten inhibits Akt and prevents renal fibrosis
Keywords: Fibrosis; Anti-fibrotic; PTEN; Akt; TGFβ1; Hypoxia;
Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis
Keywords: ACOX-1; acyl-coenzyme A oxidase 1; ALT; alanine aminotransferase; apoE; apolipoprotein E; Arg-1; arginase-1; ASTX; astaxanthin; Casp; caspase; CVD; cardiovascular disease; CPT-1α; carnitine palmitoyltransferase 1α; CD68; cluster of differentiation 68; C
Cytochrome P450-derived eicosanoids and heart function
Keywords: AA; arachidonic acid; ACS; acute coronary syndrome; ALA; alpha-linolenic acid; AMI; acute myocardial infarction; AMPK; 5Ⲡadenosine monophosphate-activated protein kinase; Ang II; angiotensin II; ANP; atrial natriuretic peptide; BaP; benzo(α)pyrene; BK
Anti-fibrotic effects of chronic treatment with the selective FXR agonist obeticholic acid in the bleomycin-induced rat model of pulmonary fibrosis
Keywords: ACE2; angiotensin I converting enzyme 2; AGT; angiotensinogen; ATI; alveolar epithelial cells type I; ATII; alveolar epithelial cells type II; BALF; bronchial alveolar lavage fluid; BMP2; bone morphogenetic protein 2; BMPR1A; bone morphogenetic protein re
Quantification of angiogenic sprouting under different growth factors in a microfluidic platform
Keywords: GF/GFs; growth factors; ECM; extracellular matrix; EC/ECs; endothelial cells; PDGF-BB; Human Platelet Derived Growth Factor-BB; VEGF; Vascular Endothelial Growth Factor; TGFβ1; Human Transforming Growth Factor-Beta 1; BMP2; Human Bone Morphogenetic Prote
Characterisation of a novel, high affinity and selective αvβ6 integrin RGD-mimetic radioligand
Keywords: αvβ6; alpha-v beta-6; RGD; arginyl-glycinyl-aspartic acid; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; DPU; Discovery Performance Unit; DMSO; dimethyl sulphoxide; ELISA; enzyme-linked immunosorbent assay; FCS; foetal calf serum; HE
Bone marrow fibrosis with fibrocytic and immunoregulatory responses induced by β-catenin activation in osteoprogenitors
Keywords: Wnt/β-catenin signaling; Bone marrow; Fibrosis; TGFβ1; Immunoregulatory responses;
Expression of transforming growth factor β1 promotes cholangiocarcinoma development and progression
Keywords: TGFβ1 inhibitor; Liver fibrosis; Bile duct tumor; miRNA-34a; CCA; cholangiocarcinoma; TGFβ1; transforming growth factor beta 1; miR-34a; microRNA-34a; shRNA; short hairpin RNA; FBS; fetal bovine serum; BDE-Neu; HER2/Neu oncogene; GAPDH; glyceraldehyde-3
Synergistic effect of vitamin D and low concentration of transforming growth factor beta 1, a potential role in dermal wound healing
Keywords: αSMA; alpha smooth muscle actin; COL1; type 1 collagen; CTGF; connective tissue growth factor; ECM; extracellular matrix; FN1; fibronectin 1; HPRT; hypoxanthine-guaninephosphoribosyltransferase gene; HTS; hypertrophic scar (s); siRNA; small interfering R
A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells
Keywords: EOC; epithelial ovarian cancer; PTM; post-translational modification; GALNT3; N-acetylgalactosaminyltransferase 3; GalNAc-Ts; GalNAc-transferases; KD; knockdown; shRNA; short hairpin RNA; siRNA; small interfering RNA; MUC1; mucin-1; Ac4GalNAz; peraceetyla
Integrins and integrin-related proteins in cardiac fibrosis
Keywords: α-SMA; α-smooth muscle actin; Ang II; angiotensin II; CFs; cardiac fibroblasts; CM; cardiac myocyte; ED-A FN; ED-A fibronectin; EC; endothelial cells; EndMT; endothelial-mesenchymal transition; EMT; epithelial-mesenchymal transition; ECM; extracellu
Collagen VI-NG2 axis in human tendon fibroblasts under conditions mimicking injury response
Keywords: TGFβ1; transforming growth factor β1; PCM; pericellular matrix; Tendon repair; Collagen VI; NG2 proteoglycan; Transforming growth factor β1; Cell migration;
Chronic expression of Ski induces apoptosis and represses autophagy in cardiac myofibroblasts
Keywords: Myofibroblast; Ski; Apoptosis; Autophagy; Cardiac fibrosis; TGFβ1;
Effect of MTHFR, TGFβ1, and TNFB polymorphisms on osteoporosis in rheumatoid arthritis patients
Keywords: ACR; American College of Rheumatology; BMD; bone mineral density; CI; confidence interval; LTA; lymphotoxin alpha; MHC; major histocompatibility complex; MTHFR; methylene tetrahydrofolate reductase; OR; odds ratio; OP; osteoporosis; Ï2; Pearson chi squar
mAb C19 targets a novel surface marker for the isolation of human cardiac progenitor cells from human heart tissue and differentiated hESCs
Keywords: CPC; cardiac progenitor cell; mAb; monoclonal antibody; hESC; human embryonic stem cell; MACS; magnetic-activated cell sorting; EB; embryoid body; Sca-1; stem cell antigen-1; KDR; kinase domain receptor; TGFβ1; transforming growth factor beta 1; cTnI; ca
Chronic lung injury in the neonatal rat: Up-regulation of TGFβ1 and nitration of IGF-R1 by peroxynitrite as likely contributors to impaired alveologenesis
Keywords: Peroxynitrite; Protein Nitration; Growth factors; Alveolar formation; Oxygen toxicity; Bronchopulmonary Dysplasia; TGFβ1;
Label-free relative quantification applied to LC-MALDI acquisition for rapid analysis of chondrocyte secretion modulation
Keywords: Extracellular matrix; Cartilage; Chondrocyte; Secretome; TGFβ1; Profile Analysis;
Redox-regulated fate of neural stem progenitor cells
Keywords: ARE; antioxidant response element; bHLH; basic helix-loop-helix; BMI1; B lymphoma Mo-MLV insertion region 1 homolog; CtBPs; C-terminal binding proteins; DLL4; delta-like protein 4; DVL; disheveled; DOUX; dual oxidases; ES; embryonic stem cells; EGFR; epid
Vasoprotective effects of neurocompensatory response to balloon injury during diabetes involve the improvement of Mas signaling by TGFβ1 activation
Keywords: Angiotensin-(1-7); Carotid balloon injury; Type I-diabetes; Hydrogen peroxide; TGFβ1;
ANRIL inhibits p15INK4b through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma
Keywords: ANRIL; antisense non-coding RNA in the INK4 locus; ESCC; esophageal squamous cell carcinoma; qPCR; quantitative real-time polymerase chain reaction; TGFβ1; transforming growth factor β1; lncRNAs; long non-coding RNAs; TβRII; TGFβ type II receptor; Tβ
Research ArticleGli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor β1 in mice
Keywords: HE; hepatic encephalopathy; AOM; azoxymethane; TGFβ1; transforming growth factor beta 1; Gli1; glioma-associated oncogene homolog 1; TGFβR2; TGFβ receptor 2; Shh; sonic hedgehog; Ihh; indian hedgehog; HBC; (2-hydropropyl)-β-cyclodextrin; VM; vivo-morp
NFkappaB activation is essential for miR-21 induction by TGFβ1 in high glucose conditions
Keywords: MicroRNA; miR-21; Diabetic wound healing; TGFβ1; NFκB;
Schisandrin B suppresses TGFβ1-induced stress fiber formation by inhibiting myosin light chain phosphorylation
Keywords: Schisandra chinensis; Schisandrin B; TGFβ1; Stress fiber; Vascular smooth muscle cell; Vascular fibrosis;
Paracrine interactions between LNCaP prostate cancer cells and bioengineered bone in 3D in vitro culture reflect molecular changes during bone metastasis
Keywords: AR; androgen receptor; hOB; human osteoblast; IL-6; Interleukin 6; IPA; Ingenuity Pathway Analysis; KLK; kallikrein; PSA; prostate specific antigen; KRT8; cytokeratin 8; PCa; prostate cancer; PEG; Polyethylene glycol; TEB; tissue engineered bone construct
HMGA2 induces transcription factor Slug expression to promote epithelial-to-mesenchymal transition and contributes to colon cancer progression
Keywords: ChIP; chromatin immunoprecipitation; DAPI; 4â²,6-diamidino-2-phenylindole dihydrochloride; EGF; epidermal growth factor; EMT; epithelial-to-mesenchymal transition; ERK1/2; extracellular signal-regulated kinase 1/2; FBS; fetal bovine serum; HMGA2; high mo
Nrf2 ameliorates diabetic nephropathy progression by transcriptional repression of TGFβ1 through interactions with c-Jun and SP1
Keywords: DM; diabetes mellitus; DN; diabetic nephropathy; ESDR; end-stage renal disease; GFR; glomerular filtration rate; GBM; glomerular basement membrane; ECM; extracellular matrix; ROS; reactive oxygen species; Nrf2; nuclear factor erythroid 2-related factor 2;
Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response
Keywords: iNOS; lupus nephritis; NF-κB; Nrf2; ROS; TGFβ1;
Synergistic effects of chitosan scaffold and TGFβ1 on the proliferation and osteogenic differentiation of dental pulp stem cells derived from human exfoliated deciduous teeth
Keywords: SHED; Chitosan; TGFβ1; Proliferation; Osteogenic differentiation;
Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model
Keywords: 3D tumor model; Boolean model; EMT; Invasion; Personalized medicine; Targeted therapy; BioVaSc; Biological Vascularized Scaffold; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; MUC1; mucin-1; PI; proliferation index; TGF
Tolerogenic dendritic cells generated with IL-10/TGFβ1 relieve immune thrombocytopenia in mice
Keywords: Immune thrombocytopenia; Tolerogenic dendritic cells; Platelet; IL-10; TGFβ1;
TGFβ1 alters androgenic metabolites and hydroxysteroid dehydrogenase enzyme expression in human prostate reactive stromal primary cells: Is steroid metabolism altered by prostate reactive stromal microenvironment?
Keywords: 6S; cancer-derived primary stromal cells; A-dione; 5α-androstanedione; 5-diol; androstenediol; 4-dione; androstenedione; ANOVA; analysis of variance; AR; androgen receptor; DHEA; dehydroepiandrosterone; DHEA sulfate; DHEAS; DHT; dihydrotestosterone; DMEM
Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells
Keywords: MSC; mesenchymal stem cell; SMC; smooth muscle cell; BMP4; bone morphogenetic protein 4; Egr2; early growth response 2; Egr1; early growth response 1; Tgfβ1; transforming growth factor β1; α-SMA; actin alpha 2 smooth muscle aorta; Srf; serum response f
Activation of integrin β1-focal adhesion kinase-RasGTP pathway plays a critical role in TGF beta1-induced podocyte injury
Keywords: TGFβ1; Integrin; FAK; Grb2; GTP-Ras; Podocyte apoptosis;
Transdermal siRNA-TGFβ1-337 patch for hypertrophic scar treatment
Keywords: HSc; hypertrophic scar; TGFβ1; transforming growth factor, beta 1; TGF-β2; transforming growth factor, beta 2; TGF-β3; transforming growth factor, beta 3; siRNA; small interfering RNA; G1; G1 phase of the cell cycle; LAP; latency-associated peptide; IH
Coronary adventitial cells are linked to perivascular cardiac fibrosis via TGFβ1 signaling in the mdx mouse model of Duchenne muscular dystrophy
Keywords: Muscular dystrophy; Fibrosis; TGFβ1; Sca1; Type I collagen; Perivascular; Adventitia;
The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes
Keywords: RAAS; renin-angiotensin-aldosterone system; AngII; angiotensin II; BMI; body-mass index; 25(OH)D; 25-hydroxyvitamin D; 1,25(OH)2D; 1,25-dihydroxyvitamin D; PTH; parathyroid hormone; PAI-1; plasminogen activator inhibitor 1; IL-6; interleukin 6; HOMA-I
Nop-7-associated 2 (NSA2), a candidate gene for diabetic nephropathy, is involved in the TGFβ1 pathway
Keywords: NSA2; Nop-7-associated 2; TGFβ1; transforming growth factor beta 1; HMCL; human mesangial cell line; siRNA; short interfering RNA; NG; normal glucose; HG; high glucose; NSA2; TGFβ1; Hyperglycemia; Nuclear translocation; Diabetic nephropathy;
Podocytes and the struggle against glucose toxicity: New targets for treatment?
Keywords: ROS; reactive oxygen species; GBM; glomerular basement membrane; TGFβ1; transforming growth factor β1; ATP; adenosine triphosphate; GLUT1; glucose transporter 1; DCCT; Diabetes Control and Complications Trial; EDIC; Epidemiology of Diabetes Intervention
TGFβ1 SNPs and radio-induced toxicity in prostate cancer patients
Keywords: TGFβ1; Radiotherapy; Toxicity; Prostate cancer; Polymorphism; SNP;
Potentiation of amyloid-β peptide neurotoxicity in human dental-pulp neuron-like cells by the membrane lipid peroxidation product 4-hydroxynonenal
Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; DAPI; 4,6-diamidino-2-phenylindole; DPNLC; dental-pulp neuron-like cells; DPPC; dental-pulp progenitor cells; GFAP; glial fibrillary acidic protein; HHE; trans-4-hydroxy-2-hexenal; HNE; 4-hydroxynonenal; IL; inter