Keywords: Escherichia coli; Staphylococcus aureus; Bovine mammary epithelial cells; TLR4; TLR2; NF-κB;
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Keywords: LPS; lipopolysaccharide; LBP; lipopolysaccharide binding protein; CI; cold ischemia; WI/R; warm ischemia/reperfusion; LTx; liver transplantation; I/R; ischemia/reperfusion; CD14; cluster of differentiation 14; TLR4; toll-like receptor 4; TNF-α; tumor nec
Keywords: LT; leukotriene; FABP; fatty acid binding protein; AFABP; adipocyte fatty acid binding protein; EFABP; epithelial fatty acid binding protein; HFABP; heart fatty acid binding protein; HETE; hydroxyeicosatetraenoic acid; PG; prostaglandin; MCP-1; monocyte c
Keywords: PAI-1; plasminogen activator inhibitor-1; uPA; urokinase; tPA; tissue plasminogen activator; NF-κB; nuclear factor kappa-B; LPS; lipopolysaccharide; TNF; tumor necrosis factor; IL-1; interleukin-1; IL-6; interleukin-6; TLR4; toll-like receptor 4; ERK; ex
Keywords: ANOVA; analysis of variance; AUC; areas under the curve; BSA; bovine serum albumin; ELISA; enzyme-linked immunosorbent assay; GFAP; glial fibrillary acidic protein; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; HHBSS; Hank's HEPES-buffered
Keywords: BBB; blood-brain barrier; EP; ethyl pyruvate; HMGB1; high-mobility group box1; ICH; intracerebral hemorrhage; RAGE; receptor for advanced glycation end products; TLR4; toll-like receptor-4; TUNEL; terminal deoxynucleotidyl transferase-mediated dUTP-biot
Keywords: HMGB1; Necrosis; Apoptosis; TLR4; RAGE;
Keywords: Interleukins; Inflammation; Lipopolysaccharide; M1-M2; Macrophage; Neuroinflammation; Neuroprotection; Neuronal cell death; TLR4; Drug-screening;
Keywords: Puerarin; Nickel; Liver; Inflammation; TLR4; CREBALT, alanine aminotransferase; AST, aspartate aminotransferase; CREB, cAMP-responsive element binding protein; COX-2, cyclooxygenase-2; IL-6, interleukin-6; NF-κB, nuclear factor-κB; Ni, nickel; ROS, reacti
Keywords: Cancer; neuropathic pain; TLR4; MCP-1; TNF-α
Keywords: Adolescence; Binge ethanol treatment; TLR4; Epigenetic changes; Anxiety-like behavior; Ethanol preference; Rewarding effects; Prelimbic medial prefrontal cortex
Reduced release of TNFα and IP-10 after ex vivo blood stimulation with endotoxin is associated with poor outcome after stroke
Keywords: Stroke; Inflammation; Outcome; Cytokines; DAMPS; damage-associated molecular patterns; GM-CSF; granulocytemacrophage colony-stimulating factor; HMGB1; high mobility group box 1; IL; interleukin; INF; interferon; IP-10; interferon-gamma-inducible protein 1
Investigation into the genetic diversity in toll-like receptors 2 and 4 in the European badger Meles meles
Keywords: Toll-like receptor; Polymorphism; Badger; Meles meles; TLR2; TLR4;
Activation of liver X receptors inhibit LPS-induced inflammatory response in primary bovine mammary epithelial cells
Keywords: Liver X receptors; T0901317; TLR4; Lipid raft; Cytokines; NF-κB;
Melatonin mediated Foxp3-downregulation decreases cytokines production via the TLR2 and TLR4 pathways in H. pylori infected mice
Keywords: Melatonin; H. pylori; TLR2; TLR4; Foxp3; MAPK; NF-κ B;
LPS-induces IL-6 and IL-8 gene expression in bovine endometrial cells “through DNA methylation”
Keywords: LPS; Lipopolysaccharide; TLR4; Toll-Like Receptor 4; IL-6; interleukin 6; IL-8; interleukin 8; MeCP2; methyl CpG-binding protein 2; ELISA; Enzyme-linked immunosorbent assay; qRT-PCR; RNA extraction and quantitative real-time PCR; cDNA; complementary DNA;
PGE2 downregulates LPS-induced inflammatory responses via the TLR4-NF-κB signaling pathway in bovine endometrial epithelial cells
Keywords: PGE2; Bovine endometrial epithelial cells; TLR4; Inflammatory response;
Decabromodiphenyl ether (BDE-209) enhances foam cell formation in human macrophages via augmenting Toll-like receptor 4-dependent lipid uptake
Keywords: BDE-209; Macrophages; Foam cell formation; TLR4; Atherosclerosis;
Effects of guluronic acid (G2013) on SHIP1, SOCS1 induction and related molecules in TLR4 signaling pathway
Keywords: G2013; Guluronic acid; SHIP1; SOCS1; TLR4; MyD88;
LPS enhances platelets aggregation via TLR4, which is related to mitochondria damage caused by intracellular ROS, but not extracellular ROS
Keywords: Lipopolysaccharide; TLR4; Platelet aggregation; Intracellular ROS;
Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia
Keywords: SIRT1 polymorphism; Oxidative stress; TLR4; IL-7; Alzheimer's disease;
MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice
Keywords: miR-29a; Cholestasis; Liver fibrosis; TLR2; TLR4; Proinflammatory cytokines;
miR-93-3p alleviates lipopolysaccharide-induced inflammation and apoptosis in H9c2 cardiomyocytes by inhibiting toll-like receptor 4
Keywords: Cardiomyocytes; Apoptosis; LPS; miR-93-3p; TLR4;
Treatment targets for M2 microglia polarization in ischemic stroke
Keywords: PACAP; pituitary adenylate cyclase-activating polypeptide; OGA; beta-N-acetylglucosaminidase; FAM19A3; TAFA3, TAFA family (TAFA1-5); TPA; tissue plasminogen activator; GSH; glutathione-SH; NGF; nerve growth factor; BCL-2/BCL-X1; B cell leukemia/lymphoma
Analgesic effects of TLR4/NF-κB signaling pathway inhibition on chronic neuropathic pain in rats following chronic constriction injury of the sciatic nerve
Keywords: TLR4; NF-κB signaling pathway; Chronic neuropathic pain; Chronic constriction injury; Mechanical withdrawal threshold; Thermal withdrawal latency;
Let-7b ameliorates Crohn's disease-associated adherent-invasive E coli induced intestinal inflammation via modulating Toll-Like Receptor 4 expression in intestinal epithelial cells
Keywords: CD; Crohn's disease; AIEC; adherent-invasive E coli; TLR4; toll-like receptor 4; LPS; lipopolysaccharide; IECs; intestinal epithelial cells; WT; wild type; IL-10 KO; interleukin-10 knockout; SPF; specific pathogen free; TNF-α; tumor necrosis factor-α;
TLR4 mediates high-fat diet induced physiological changes in mice via attenuating PPARγ/ABCG1 signaling pathway
Keywords: TLR4; Inflammation; Lipid accumulation; PPARγ; ABCG1;
Anti-inflammatory action of Athyrium multidentatum extract suppresses the LPS-induced TLR4 signaling pathway
Keywords: LPS; lipopolysaccharide; ALI; acute lung injury; BALF; bronchoalvelar lavage fluid; NO; nitric oxide; PGE2; prostaglandin E2; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase; TLR4; toll-like receptor 4; TNF-α; tumor necrosis factor-α; IL; i
Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4
Keywords: Streptococcus pneumoniae; Autolysis; DNA-binding protein; DnaK; EF-Tu; GAPDH; TLR4;
A pathogenetic role for M1 macrophages in peritoneal dialysis-associated fibrosis
Keywords: PD; Peritoneal dialysis; PDFs; peritoneal dialysis fluids; PF; peritoneal fibrosis; LC; Liposomes clodronate; LV; Liposomes vehicle; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; TLR4; Toll-like receptor 4; α-SMA; alpha-smooth muscle
Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways
Keywords: Akt; protein kinase B; Atg; autophagy related gene; CNS; central nervous system; COX-2; cyclooxygenase-2; CQ; chloroquine; ERK; extracellular signal-regulated kinase; IL-1β; interleukin-1β; iNOS; inducible nitric oxide synthase; JNK; c-jun NH2-terminal
Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549â¯cells
Keywords: Nickel; Lung cancer cell; Quercetin; Chrysin; TLR4; NF-κB; IκB; inhibitor of NF-κB; IKKβ; IκB kinase β; Myd88; myeloid differentiation factor 88; MMP-9; metalloproteinases 2 and 9; TLR4; Toll-like receptor;
Atractylodin attenuates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome and TLR4 pathways
Keywords: Atractylodin; Inflammation; Acute lung injury; NLRP3; TLR4;
The posttraumatic activation of CD4+ T regulatory cells is modulated by TNFR2- and TLR4-dependent pathways, but not by IL-10
Keywords: CARS; compensatory anti-inflammatory response syndrome; CD4+ Treg; CD4+ FoxP3+ regulatory T cell; IL-10; interleukin-10; MFI; mean fluorescence intensity; MODS; multiple organ dysfunction syndrome; PKC-θ; protein kinase C-θ; ROTEM®; rotational thromboe
Molecular characterization and expression analysis of TLR1 and TLR4 from the endangered fish Dabry's sturgeon (Acipenser dabryanus)
Keywords: Acipenser dabryanus; TLR1; TLR4; Gene expression; Immunity;
Molecular mechanism of LPS-induced TNF-α biosynthesis in polarized human macrophages
Keywords: TTP; tristetraprolin; TRIF; TIR-domain-containing adapter-inducing interferon-β; TRAM; TRIF-related adapter molecule; IRF3; interferon regulatory factor 3; IFNAR; interferon-α/β receptor; ActD; actinomycin D; TIRAP; TIR-domain-containing adapter protei
LPS promotes HBO1 stability via USP25 to modulate inflammatory gene transcription in THP-1 cells
Keywords: HBO1; histone acetyltransferase binding to origin recognition complex 1; UPS25; ubiquitin specific peptidase 25; LPS; lipopolysaccharide; Cdt1; Chromatin Licensing And DNA Replication Factor 1; HDAC11; histone deacetylase 11; MCM; Minichromosome Maintenan
Mogroside IVE attenuates experimental liver fibrosis in mice and inhibits HSC activation through downregulating TLR4-mediated pathways
Keywords: α-SMA; α-smooth muscle actin; ALT; alanine aminotransferase; AST; aspartate aminotransferas; CCl4; carbon tetrachloride; Col I; collagen I; ECM; extracellular matrix; HIF; hypoxia inducible factor; HSCs; hepatic stellate cells; JNK; c-Jun N-terminal kin
LncRNA myocardial infarction-associated transcript (MIAT) contributed to cardiac hypertrophy by regulating TLR4 via miR-93
Keywords: LncRNA; MIAT; MiR-93; TLR4; AngII; Cardiac hypertrophy;
Expression and function of TLR4- induced B1R bradykinin receptor on cardiac fibroblasts
Keywords: Cardiac Fibroblast; TLR4; Kinin Receptors; Collagen; PGI2; NO;
Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38-MAPK and TLR4/NF-κB signaling pathways
Keywords: Oridonin; Diabetic nephropathy; Inflammatory response; TLR4; p38-MAPK; NF-κB;
Ubiquitination and SUMOylation in the chronic inflammatory tumor microenvironment
Keywords: Inflammation-associated cancer; Ubiquitin-proteasome system (UPS); Small ubiquitin-like modifier (SUMO); Tumor microenvironment; Cytokine profile; Transcription factors; 15d-PGJ2; 15-Deoxy-Delta-12,14-prostaglandin J2; AR; androgen receptor; Ala; alanine;
Ex-vivo generation of drug-eluting islets improves transplant outcomes by inhibiting TLR4-Mediated NFkB upregulation
Keywords: Islet; Surface modification; Diabetes; TLR4; Inflammation; Transplantation;
Myeloid differentiation protein 2 induced retinal ischemia reperfusion injury via upregulation of ROS through a TLR4-NOX4 pathway
Keywords: MD2; TLR4; HMGB1; NOX4; Retinal ischemia-reperfusion injury;
Protective effects of total alkaloids from Dendrobium crepidatum against LPS-induced acute lung injury in mice and its chemical components
Keywords: Dendrobium crepidatum; Orchidaceae; Acute lung injury; Indolizine-type alkaloids; TLR4; TAD; total alkaloids of D. crepidatum; LPS; lipopolysaccharide; ALI; acute lung injury; prednisone; PDN; MPO; myeloperoxidase; TLR4; toll-like receptor 4; MyD88; myel
The Selective Glucocorticoid Receptor Modulator Cort 113176 Reduces Neurodegeneration and Neuroinflammation in Wobbler Mice Spinal Cord
Keywords: ALS; amyotrophic lateral sclerosis; CD11b; a CD antigen that contains a conserved domain and serves as a marker of microglia; GFAP; glial fibrillary acidic protein; GLAST; glutamate aspartate transporter; GLT-1; glutamate transporter 1; GR; glucocorticoid
Ulinastatin mediates suppression of regulatory T cells through TLR4/NF-κB signaling pathway in murine sepsis
Keywords: Regulatory T cell (Treg); TLR4; Ulinastatin; Sepsis; Inflammation; Immune response;
MyD88 and TLR4 Expression in Epithelial Ovarian Cancer
Keywords: BRCA1; breast cancer susceptibility gene 1; BRCA2; breast cancer susceptibility gene 2; CCOC; clear cell ovarian carcinoma; DAB; 3,3â²-diaminobenzidine; ENOC; endometrioid ovarian carcinoma; EOC; epithelial ovarian cancer; HGSOC; high-grade serous ovaria
p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice
Keywords: p204; LPS; TLR4; IFN-β; Inflammatory responses; Macrophages;
Human monocytes stimulated by Shiga toxin 1a via globotriaosylceramide release proinflammatory molecules associated with hemolytic uremic syndrome
Keywords: Gb3Cer; globotriaosylceramide; HC; hemorrhagic colitis; HUS; hemolytic uremic syndrome; Stx; Shiga toxins; Stx1a; Shiga toxin 1a; Stx2a; Shiga toxin 2a; STEC; Shiga toxins-producing Escherichia coli; TLR4; toll-like receptor 4; Proinflammatory mediators;