Li-Fraumeni syndrome: Adrenal cortical tumor in a newborn followed by a choroid plexus tumor
Keywords: Adrenal cortical tumor; Choroid plexus carcinoma; TP53; Li-Fraumeni syndrome;
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Biallelic TP53 gain of function mutations in rapidly progressing solid tumors
Keywords: TP53; Gain of function mutation; Next generation sequencing;
Decreased osteoprogenitor proliferation precedes attenuation of cancellous bone formation in ovariectomized rats treated with sclerostin antibody
Keywords: ANOVA; analysis of variance; BrdU; 5-bromo-2â²-deoxyuridine; CDKN1A; cyclin-dependent kinase inhibitor 1A; CDKN2A; CDKN inhibitor 2A; CE; coefficient of error; CV; coefficient of variation; D; day; E2F1; E2F transcription factor 1; FOXM1; Forkhead box pr
TP53 Mutation as Potential Negative Predictor for Response of Anti-CTLA-4 Therapy in Metastatic Melanoma
Keywords: Anti-CTLA-4; TP53; Melanoma; Biomarker; Tumor mutational burden;
Cross talk between TP53 and c-Myc in the pathophysiology of Diamond-Blackfan anemia: Evidence from RPL11-deficient in vivo and in vitro models
Keywords: Diamond-Blackfan anemia; Ribosomopathy; TP53; c-Myc; Zebrafish; RPL11;
Integration of bioinformatics and experiments to identify TP53 as a potential target in Emodin inhibiting diffuse large B cell lymphoma
Keywords: Emodin; Non-Hodgkin's Lymphoma; Bioinformatics; Interaction network; TP53;
Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer
Keywords: CIP2A; SET; PME-1; MAPK; JAK2; ERK; PPP2R1A; PPP2R2A; PPP2R5A; PPP2R5C; MYC; TP53; E2F1; AKT; Feedback;
Contribution of genotoxic anticancer treatments to the development of multiple primary tumours in the context of germline TP53 mutations
Keywords: TP53; Li-Fraumeni syndrome; Multiple primary cancers; Anticancer treatments; Genotoxicity;
Erythroleukemia-historical perspectives and recent advances in diagnosis and management
Keywords: Pure erythroid leukemia; Acute erythroleukemia - M6a subtype; Acute erythroleukemia - M6b subtype; Erythroblasts; GATA1 protein; PU.1 protein; TP53; Bromodomain protein; MicroRNA;
Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line
Keywords: S-(1,2-dichlorovinyl)-l-cysteine [DCVC]; Trichloroethylene [TCE]; Apoptosis; Lipid peroxidation; Extravillous trophoblasts; Placenta; BAK1; BCL2-antagonist/killer 1; BAX; BCL2-associated X protein; BCL-2; B-cell CLL/lymphoma 2; BCL2A1; BCL2-related protei
Part A: Temporal and dose-dependent transcriptional responses in the liver of fathead minnows following short term exposure to the polycyclic aromatic hydrocarbon phenanthrene
Keywords: SREBF1; sterol regulatory element binding transcription factor 1; FASN; fatty acid synthase; HSD17B12; hydroxysteroid (17-beta) dehydrogenase 12; ACACA; acetyl-CoA carboxylase alpha; CYB5A; cytochrome b5 type A (microsomal); SLC27A4; solute carrier family
Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals
Keywords: TP53; Drug sensitivity; Targeted therapeutics; Signal transduction inhibitors;
Regulation and biological roles of the multifaceted miRNA-23b (MIR23B)
Keywords: miRNAs; MicroRNAs; C9orf3; Chromosome 9 Open Reading Frame 3; pri-miRNAs; primary miRNA; pre-miRNAs; precursor miRNAs; miRISC; miRNA-induced silencing complex; ECs; endothelial cells; VSMCs; vascular smooth muscle cells; ACTA2; smooth muscle α-actin; MYH
Influence of silibinin and β-β-dimethylacrylshikonin on chordoma cells
Keywords: Chordoma; β-β-dimethylacrylshikonin; Silibinin; Apoptosis; ACTB; actin beta; AKT; AKT serine/threonine kinase; BAD; BCL2 associated agonist of cell death; BAK; BCL2 antagonist/killer; BAX; BCL2 associated X protein; BCL-2; B cell leukemia/lymphoma 2; BH
Assessment of the expression of the BRCA1, BRCA2, TP53, MDM2, BAX and CASP-3 genes in normal and tumor tissues for patients with breast cancer in Morocco
Keywords: Breast cancer; BRCA1; TP53; BAX; CASP-3; Tumor;
The prognostic value of TP53 and its correlation with EGFR mutation in advanced non-small cell lung cancer, an analysis based on cBioPortal data base
Keywords: TP53; EGFR; Non-small cell lung cancer; Mutation; Prognosis; Exon;
Identification of key microRNAs associated with diffuse large B-cell lymphoma by analyzing serum microRNA expressions
Keywords: DLBCL; diffuse large B-cell lymphoma; DEMs; Differentially expressed miRNAs; KEGG; Kyoto Encyclopedia of Genes and Genomes; PPI; protein-protein interaction; qRT-PCR; quantitative reverse transcription polymerase chain reaction; TP53; tumor protein p53;
Genetic profiles of different subsets of Merkel cell carcinoma show links between combined and pure MCPyV-negative tumors
Keywords: Merkel cell carcinoma; SNP microarray; Copy number aberrations; Next-generation sequencing; TP53; RB1;
HPV infection and p16INK4A and TP53 expression in rare cancers of the uterine cervix
Keywords: BSCC; basaloid squamous cell carcinoma; BE-RMS; botryoid-type embryonic rhabdomyosarcoma; GS without AML; granulocytic sarcoma without acute myeloid leukemia; LMS; leiomyosarcoma; PNET; primitive neuroectodermal tumor; SCNEC; small cell neuroendocrine car
A chimeric protein PTEN-L-p53 enters U251 cells to repress proliferation and invasion
Keywords: PTEN-Long; TP53; PTEN-L-p53; Cancer; U251 cells;
Clinical significance and prognostic relevance of KRAS, BRAF, PI3K and TP53 genetic mutation analysis for resectable and unresectable colorectal liver metastases: A systematic review of the current evidence
Keywords: Colorectal liver metastases; Gene; KRAS; BRAF; TP53; PIK3CA;
Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer
Keywords: Oncogene; p21; PPM1D; TP53; Wip1;
ROS modifiers and NOX4 affect the expression of the survivin-associated radio-adaptive response
Keywords: Survivin; NOX4; ROS modifiers; TP53; Adaptive response; Ionizing radiation;
Ampullary carcinoma-A genetic perspective
Keywords: AVC; ampulla of vater carcinoma; KRAS; Kirsten rat sarcoma viral oncogene homolog; OS; overall survival; RFS; recurrence free survival; HER2; human epidermal growth factor receptor 2; BRAF; B rapidly activated fibrosarcoma; BRCA2; breast cancer 2; TP53; t
C9orf72 is essential for neurodevelopment and motility mediated by Cyclin G1
Keywords: ALS; amyotrophic lateral sclerosis; C9-ALS-FTD; patients with C9orf72-mediated ALS-FTD; DENN; differentially expressed in normal and neoplastic cell; EGFP; enhanced green fluorescent protein; FTD; frontotemporal dementia; MO; morpholino; qPCR; quantit
Impact of obesity and overweight on DNA stability: Few facts and many hypotheses
Keywords: AGEs; advanced glycation end products; AP-1; activating protein -1; APE1; apurinic/apyrimidinic endonuclease 1; BER; base excision repair; BMI; body mass index; CAF; cafeteria diet; CAT; Catalase; CBMN-Cyt; cytokinesis block micronucleus cytome assay; CEL
Mutations in TP53, PIK3CA, PTEN and other genes in EGFR mutated lung cancers: Correlation with clinical outcomes
Keywords: Mutation; Lung cancer; Adenocarcinoma; EGFR; TP53; PIK3CA; PTEN; Kinase inhibitor; Erlotinib;
Do cytogenetics affect the post-remission strategy for older patients with AML in CR1?
Keywords: Acute myeloid leukemia; Age; AML; Azacitidine; Clofarabine; Consolidation; CPX-351; Cytarabine; Cytogenetics; Daunorubicin; Decitabine; Minimal residual disease; MRD; Reduced intensity conditioning; RIC; Risk; TP53; Transplant;
ESR1 single nucleotide polymorphism rs1062577 (c.*3804TÂ >Â A) alters the susceptibility of breast cancer risk in Iranian population
Keywords: ATM; ataxia-telangiectasia mutated; BRCA1; BReast CAncer gene 1; BRCA2; BReast CAncer gene 2; CHECK2; checkpoint kinase 2; ER; estrogen receptor; ESR1; estrogen receptor 1; HER2; human epidermal growth factor 2; PR; progesterone receptor; PTEN; phosphatas
TP53 gene status is a critical determinant of phenotypes induced by ALKBH3 knockdown in non-small cell lung cancers
Keywords: Human AlkB homolog 3; Non-small cell lung cancer; TP53; p53; Apoptosis; 1-meA; 1-methyladenine; 3-meC; 3-methylcytosine; ALK; anaplastic lymphoma kinase; ALKBH3; AlkB homolog 3; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and RAD3-relat
Constitutional mosaicism of a de novo TP53 mutation in a patient with bilateral choroid plexus carcinoma
Keywords: TP53; mosaic mutation; de novo; choroid plexus carcinoma; next generation sequencing;
Original ArticleChronic lymphocytic leukemia with isochromosome 17q: An aggressive subgroup associated with TP53 mutations and complex karyotypes
Keywords: Chronic lymphocytic leukemia; Isochromosome 17q; TP53; IGHV; Complex karyotype; Survival;
Original ArticlePrognostic and predictive effects of TP53 co-mutation in patients with EGFR-mutated non-small cell lung cancer (NSCLC)
Keywords: TP53; EGFR; Non-small cell lung cancer; Survival; Tyrosine kinase inhibitors;
Overexpression of TP53 mutation-associated microRNA-182 promotes tumor cell proliferation and migration in head and neck squamous cell carcinoma
Keywords: HNSCC; head and neck squamous cell carcinoma; miRNAs; microRNAs; miR-182; microRNA-182; β-TrCP2; beta-transducin repeat-containing protein-2; Head and neck squamous cell carcinoma; TP53; MicroRNA-182; Proliferation and migration; β-TrCP2;
Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis
Keywords: TP53; rs1042522; Polymorphism; Prostate cancer; Meta-analysis;
The roles of subcellularly located EGFR in autophagy
Keywords: AMPK; AMP-activated protein kinase; ATG; autophagy-related; BCL2; B-cell lymphoma 2; BCL2L1; BCL2 like 1; BNIP3; BCL2/Adenovirus E1B-binding protein Nip3; CME; clathrin-mediated endocytosis; cytoSTAT3; cytoplasmic STAT3; Dsbs; double strand breaks; ECD; e
Roles of TP53 in determining therapeutic sensitivity, growth, cellular senescence, invasion and metastasis
Keywords: TP53; miRs; MDM2; Nutlin-3 chemosensitivity; Cellular senescence; Invasion; Metastasis;
A case of oncocytic papillary cystadenocarcinoma of the parotid gland—Pathological and molecular features of a rare tumor
Keywords: Parotid gland; Cystadenocarcinoma; Mitochondria; Androgen receptor; TP53; SNP
Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients
Keywords: Adenocarcinoma; Clinicopathological characteristics; NSCLC; RET rearrangement; Smoking history; TP53;
Porocarcinomas harbor recurrent HRAS-activating mutations and tumor suppressor inactivating mutations
Keywords: Porocarcinoma; Poroma; HRAS; TP53; Epidermal growth factor receptor; RB1
Methylation levels of P16 and TP53 that are involved in DNA strand breakage of 16HBE cells treated by hexavalent chromium
Keywords: Chromium(VI); Methylation; p16; TP53; DNA strand breakage; Epigenetic biomarker
Gene expression profiling reveals the role of RIG1 like receptor signaling in p53 dependent apoptosis induced by PUVA in keratinocytes
Keywords: PUVA; 8-methoxypsoralen plus UVA; RIG-1; retinoic acid induced gene 1; MDA5; melanoma differentiation associated gene 5; MAVS; mitochondrial antiviral signaling protein; TBK; TANK-binding kinase 1; IKKε; inhibitor of kappaB kinase epsilon; IRF3; interfer
TP53 dysfunction in diffuse large B-cell lymphoma
Keywords: TP53; miRNA; Copy number alterations; MDM2; Mutation
In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma
Keywords: BRCA1/2; BRCA1 or BRCA2; CDK; cyclin-dependent kinase; FBS; heat-inactivated fetal bovine serum; HGSOC; high-grade serous ovarian carcinoma; HR; homologous recombination; IP; intraperitoneal; pADPr; poly(ADP-ribose) polymer; PARP; poly(ADP-ribose) polymer
TP53 dysfunction in CLL: Implications for prognosis and treatment
Keywords: 17p deletion; TP53; ATM; CLL; BCR kinase inhibitors; Venetoclax;
Molecular pathogenesis of pancreatic ductal adenocarcinoma
Keywords: CDKN2A; driver genes; KRAS; pancreatic ductal adenocarcinoma; PanIN; SMAD4; TP53
Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells
Keywords: ACTA2; Actin, alpha, smooth muscle; ANGPTL4; Angiopoietin-like 4; ANOVA; Analysis of variance; AXIN; Axis inhibition protein; BMP; Bone morphogenic protein; BMPR1B; BMP receptor 1B; CACNA2D3; Calcium channel, voltage-dependent, alpha 2/delta subunit 3; CC
Wilms tumor gene 1 (WT1), TP53, RAS/BRAF and KIT aberrations in testicular germ cell tumors
Keywords: Wilms tumor gene 1 (WT1); TP53; KIT; Testicular germ cell tumors; Next generation sequencing
Whole-arm translocation of der(5;17)(p10;q10) with concurrent TP53 mutations in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS): A unique molecular-cytogenetic subgroup
Keywords: Der(5;17); complex karyotypes; TP53; acute myeloid leukemia (AML); myelodysplastic syndrome (MDS)
Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence
Keywords: MITF; AKT; Phosphorylation; TP53; Senescence;