Keywords: سیستم پروتئازوم Ubiquitin; Liver; Proliferation; Cancer; Tumor-Suppressor Proteins; Progenitor Cells; BrdU; bromodeoxyuridine; cDNA; complementary DNA; C/EBP; CCAAT/enhancer binding protein; Co-IP; co-immunoprecipitation; CUGBP1; CUG triplet repeat binding protein 1; DEN; diethylni
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Keywords: سیستم پروتئازوم Ubiquitin; AD; Alzheimer's disease; CBD; corticobasal degeneration; FTD; frontotemporal degeneration; FDA; Food and Drug Administration; GST-UBL; glutathione-S-transferase-ubiquitin-like domain; HD; Huntington's disease; MWM; Morris water maze; MCI; mild cognitive i
Keywords: سیستم پروتئازوم Ubiquitin; 53BP1; p53 binding protein 1; BRCA1; breast cancer protein 1; DDB1; DNA damage-binding protein 1; DSB; double-strand break; H3; histone 3; H3K9me; methylation of histone 3 lysine 9; HR; homologous recombination; INM; inner nuclear membrane; LBR; lamin B r
Keywords: سیستم پروتئازوم Ubiquitin; BTZ; bortezomib; CFZ; carfilzomib; C-L; caspase-like; CNS; central nervous system; CT-L; chymotrypsin-like; CYPs; cytochrome P450 enzymes; iP; immunoproteasome; IXZ; ixazomib; MM; multiple myeloma; OPZ; oprozomib; PD; pharmacodynamic; PI; proteasome inhib
Keywords: سیستم پروتئازوم Ubiquitin; PD; Parkinson's disease; AD; Alzheimer's disease; ROS; reactive oxygen species; SNpc; substantia nigra pars compacta; MnSOD; manganese superoxide dismutase; CuSOD; copper superoxide dismutase; NO; nitric oxide; O2â; superoxide anion; ONOOâ; peroxy
Keywords: سیستم پروتئازوم Ubiquitin; Lipid metabolism; Muscle protein synthesis; mTOR signaling; Proteolysis; Ubiquitin proteasome system;
Keywords: سیستم پروتئازوم Ubiquitin; Cd; cadmium; Zn; zinc; Cu; copper; CdCl2; cadmium chloride; bCd; whole blood Cd; bpCd; blood plasma Cd; sCd; serum Cd; spCd; seminal plasma Cd; uCd; urine Cd; 8 -OHdG; 8-hydroxy-2â²-deoxyguanosine; E2; estradiol; FSH; follicle stimulating hormone; T; tes
Keywords: سیستم پروتئازوم Ubiquitin; AAA; ATPases associated with diverse cellular activities; 17-AAG; 17-N-allylamino-17-demethoxygeldanamycin; ABC; ATP-binding cassette; ABCE1; ATP binding cassette subfamily E member 1; AD; Alzheimer's disease; AIF; apoptosis inducing factor; Akt; Alpha se
Keywords: سیستم پروتئازوم Ubiquitin; OS; oxidative stress; CNS; central nervous system; ROS; reactive oxygen species; SOD; superoxide dismutase; CAT; catalase; Cu; copper; Zn; zinc; Mn; manganese; Fe; iron; Ni; nickel; DA; dopamine; PHOX; NADPH oxidase; Nrf2; nuclear factor erythroid 2-relat
Keywords: سیستم پروتئازوم Ubiquitin; APAP; acetaminophen; ALD; alcoholic liver disease; BAG4; Bcl2-associated athanogene 4; CCCP; carbonyl-cyanide m-chlorophenyl hydrazine; Clec16a; c-type lectin domain family 16, member A; Dfcp1; double FYVE-containing protein 1; DUB; deubiquitinating enzym
Keywords: سیستم پروتئازوم Ubiquitin; mTOR; mammalian target of rapamycin; NF-κB; nuclear factor κ B; Stat1/3; signal transducer and activator of transcription 1/3; UPS; ubiquitin proteasome system; LMP; low molecular mass protein; Proteasome; mTOR; Heart; Rapamycin; Immunoproteasome; Infla
Keywords: سیستم پروتئازوم Ubiquitin; AMPK; AMP-activated protein kinase; ASK1; apoptosis signal-regulating kinase 1; Atg; autophagy-related; ARE; AU-rich element; AUF; ARE RNA binding protein; BRF; butyrate response factor; CaMK; Ca2Â +/calmodulin-dependent protein kinase; CUGBP; CUG-binding
Keywords: سیستم پروتئازوم Ubiquitin; ASK1; apoptosis signal-regulating kinase; ALS; amyotrophic lateral sclerosis; Apaf-1; apoptotic protease-activating factor; ATF6; activating transcription factor 6; Atg12; autophagy-related gene 12; C9ORF72; chromosome 9 open reading frame 72; CHIP; carbo
Keywords: سیستم پروتئازوم Ubiquitin; ACE; angiotensin-converting enzyme; ANF; atrial natriuretic factor; BNP; brain natriuretic peptide; DCM-CD; dilated cardiomyopathy with conduction defects; EDMD; Emery-Dreifuss muscular dystrophy; EHT; engineered heart tissue; KI; knock-in; KO; knock-ou
Keywords: سیستم پروتئازوم Ubiquitin; ECM; extracellular matrix; BCC; breast cancer cell; CM; conditioned media; TEM; trans-endothelial migration; GAG; glycosaminoglycan; HS; heparan sulfate; CS; chondroitin sulfate; HA; hyaluronan; UPS; ubiquitin proteasome system; FBS; fetal bovine serum; H
Keywords: سیستم پروتئازوم Ubiquitin; Hb-Y-X; hydrophobic-tyrosine-X motif; PA; proteasome activator; CSN; COP9 signalosome; CRL; Cullin RING E3 ligase; PAN; proteasome-activating nucleotidase; Ribophagy; Ribosome autophagy; UbD; ubiquitin-binding domain; DUb; deubiquitinationg enzyme; UPS; u
Keywords: سیستم پروتئازوم Ubiquitin; Ub; ubiquitin; SCF; Skp-Cullin-F-box; HECT; homologous to E6 carboxyl terminus; RING; really Interesting New Gene; SUMO; small ubiquitin-like modifier; UPS; ubiquitin proteasome system; UFD; ubiquitin fusion degradation; ERAD; endoplasmic reticulum-associ
Keywords: سیستم پروتئازوم Ubiquitin; FOXO; forkhead box O; GC; glucocorticoids; MuRF-1; muscle RING-finger protein-1; mTOR; mammalian target of rapamycin; IGF-I; Insulin-like Growth Factor-I; eIF4E; eukaryotic translation initiation factor 4E; S6K1; ribosomal protein kinase 1; 4E-BP1; eukary
The reductase TMX1 contributes to ERAD by preferentially acting on membrane-associated folding-defective polypeptides
Keywords: سیستم پروتئازوم Ubiquitin; Endoplasmic reticulum; ER-Associated degradation; Oxido-reductase; Protein folding and quality control; TMX1; Ubiquitin proteasome system;
Novel reno-protective mechanism of Aspirin involves H2AK119 monoubiquitination and Set7 in preventing type 1 diabetic nephropathy
Keywords: سیستم پروتئازوم Ubiquitin; Diabetic nephropathy; Ubiquitin proteasome system; Histone ubiquitination; Renal fibrosis; Mysm1; Set7;
Differential protein expression of hippocampal cells associated with heavy metals (Pb, As, and MeHg) neurotoxicity: Deepening into the molecular mechanism of neurodegenerative diseases
Keywords: سیستم پروتئازوم Ubiquitin; Metal exposure; Proteomics; Pathway visualization; Neurodegenerative diseases; AD; Alzheimer's disease; APP; Amyloid precursor protein; Aβ; Amyloid-beta; CAM; Calmodulin; ETC; Electron transport chain; GAD; glutamate decarboxylase; Glu; Glutamate; GO; Ge
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
Keywords: سیستم پروتئازوم Ubiquitin; 7-AAD; 7-amino-actinomycin D; ABC; ATP-binding cassette; AEC; 3-amino-9-ethyl carbazole; ATD; acute toxicity determination; Atg5; autophagy protein 5; ATP; adenosine-5â²-triphosphate; BCL-2; B-cell lymphoma 2; Bip/GRP78; binding immunoglobulin protein/78
Overexpression of Arabidopsis ubiquitin ligase AtPUB46 enhances tolerance to drought and oxidative stress
Keywords: سیستم پروتئازوم Ubiquitin; Water stress; U-box PUB E3; Ubiquitin proteasome system; Abiotic stress; Plant U-box; Ubiquitin ligase;
Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
Keywords: سیستم پروتئازوم Ubiquitin; Nrf2; type 2 diabetes; natural products; hyperglycemia; cellular stress; insulin sensitivity; β-cell function; vascular complications; AGE; advanced glycation end products; AhR; arylhydrocarbon receptor; AMPK; AMP-activated kinase; ARE; antioxidant respo
Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase
Keywords: سیستم پروتئازوم Ubiquitin; Lipin-1; BTRC; Degradation; Polyubiquitination; Lipid metabolism; Protein localization; UPS; ubiquitin proteasome system; PAP1; phosphatidate phosphatase type-1; BTRC; beta-transducin repeat-containing protein; FBXW11; F-box and WD-40 domain protein 11; C
Redox regulation of proteasome function
Keywords: سیستم پروتئازوم Ubiquitin; Abcd1; ATP binding cassette subfamily D member 1; AD; Alzheimer's disease; ALD; adrenoleukodystrophy; ALS; amyotrophic lateral sclerosis; AP-1; activator protein-1; APP; amyloid precursor protein; CNS; central nervous system; DDI; DNA-damage inducible 1;
Alterations of ubiquitin related proteins in the pathology and development of schizophrenia: Evidence from human and animal studies
Keywords: سیستم پروتئازوم Ubiquitin; Schizophrenia; Neurodevelopmental animal model; Human brain cohort; E2 ubiquitin conjugating enzyme; E3 ligases; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; DLPFC; dorsolateral prefrontal cortex; FBXL21; F-Box and Leucine rich repeat protein
Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster
Keywords: سیستم پروتئازوم Ubiquitin; Proteasome; TDP-43 accumulation; Neurodegeneration; Drosophila; ALS; amyotrophic lateral sclerosis; IBMPDF; inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia; NMJ; neuromuscular junction; Npl4; nuclear protein localizati
Hidden targets of ubiquitin proteasome system: To prevent diabetic nephropathy
Keywords: سیستم پروتئازوم Ubiquitin; Diabetic nephropathy; Ubiquitin proteasome system; E2 conjugating enzymes; E3 ligases; Deubiquitinases; Histone ubiquitination;
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: سیستم پروتئازوم Ubiquitin; α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
Immune defects caused by mutations in the ubiquitin system
Keywords: سیستم پروتئازوم Ubiquitin; Ubiquitin; nuclear factor κB; immunodeficiency; CVID; Common variable immunodeficiency; DUB; Deubiquitinating enzyme; EDA-ID; Ectodermal dysplasia with immunodeficiency; HECT; Homologous to EGAP C-terminus; HOIL-1; Heme-oxidase iron responsive element bi
Linking muscarinic receptor activation to UPS-mediated object memory destabilization: Implications for long-term memory modification and storage
Keywords: سیستم پروتئازوم Ubiquitin; Acetylcholine; Labile; Prediction error; Recognition; Reconsolidation; Ubiquitin proteasome system;
Cyclin F: A component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer
Keywords: سیستم پروتئازوم Ubiquitin; Cyclin F; Ubiquitin proteasome system; E3 ubiquitin ligase; Amyotrophic lateral sclerosis; Cancer;
Puromycin induces SUMO and ubiquitin redistribution upon proteasome inhibition
Keywords: سیستم پروتئازوم Ubiquitin; Nuclear protein sequestration; Puromycin; Small ubiquitin-related modifier (SUMO); Ubiquitin proteasome system; Promyelocytic leukemia nuclear bodies; SUMO; small ubiquitin-related modifier; PML-NBs; promyelocytic leukemia-nuclear bodies; RNF4; really int
UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension
Keywords: سیستم پروتئازوم Ubiquitin; UPS; ubiquitin proteasome system; HS; hindlimb suspension; MuRF1; muscle ring finger protein-1; UBE2D2; ubiquitin-conjugating enzyme E2 D2; UBE2B; ubiquitin-conjugating enzyme E2 B; MHC; myosin heavy chain; SPR; surface plasmon resonance; Y2H; yeast two-h
The proteasome - victim or culprit in autoimmunity
Keywords: سیستم پروتئازوم Ubiquitin; Ubiquitin proteasome system; Proteasome-associated autoinflammatory syndromes; Interferonopathy; Autoimmune diseases; Proteasome inhibition;
Cloning and characterization of carboxyl terminus of heat shock cognate 70-interacting protein gene from the silkworm, Bombyx mori
Keywords: سیستم پروتئازوم Ubiquitin; Carboxyl terminus of heat shock cognate 70-interacting protein (CHIP); E3 ligase; Ubiquitin proteasome system; Bombyx mori
Interference with Akt signaling pathway contributes curcumin-induced adipocyte insulin resistance
Keywords: سیستم پروتئازوم Ubiquitin; Curcumin; Protein kinase B; Autophagy; Ubiquitin proteasome system; AdipocytesAkt, Protein kinase B (PKB/Akt); BFA, Bafilomycin A1; CHX, Cycloheximide; CQ, Chloroquine; Cur, Curcumin; 2-DG, 2-deoxy-D-glucose; GFPu, A green fluorescence protein (GFP) modif
Soluble receptor for advanced glycation end-products protects against ischemia/reperfusion-induced myocardial apoptosis via regulating the ubiquitin proteasome system
Keywords: سیستم پروتئازوم Ubiquitin; sRAGE; soluble receptor for advanced glycation end-products; I/R; Ischemia/Reperfusion; UPS; Ubiquitin proteasome system; LAD; Left anterior descending coronary artery; STAT; Signal transducer and activator of transcription; RAGE; Receptor for advanced gl
The ubiquitin-like modifier FAT10 in cancer development
Keywords: سیستم پروتئازوم Ubiquitin; AIPL1; aryl-hydrocarbon receptor like-1; APC/C; anaphase-promoting complex/cyclosome; DUB; deubiquitylating enzyme; EMT; epithelial-mesenchymal transition; FAT10; HLA-F adjacent transcript 10; GSK; glycogen synthase kinase; HCC; hepatocellular carcinoma;
Cardiac ubiquitin ligases: Their role in cardiac metabolism, autophagy, cardioprotection and therapeutic potential
Keywords: سیستم پروتئازوم Ubiquitin; ATG; autophagy-related gene; AMPK; AMP activated protein kinase; BECN1; beclin1; b-TrCP; beta-transducin repeat-containing protein; Cbl; Casitas B-lineage lymphoma; CHIP; Carboxyl terminus of Hsc70 interacting protein; CHMP2B; charged multivesicular body
Upregulation of MuRF1 and MAFbx participates to muscle wasting upon gentamicin-induced acute kidney injury
Keywords: سیستم پروتئازوم Ubiquitin; UPS; ubiquitin proteasome system; AKI; acute kidney injury; ATN; acute tubular necrosis; CKD; chronic kidney disease; MuRF1; muscle ring finger protein-1; MAFbx; muscle atrophy F-box protein; MUSA1; muscle ubiquitin ligase of the SCF complex in atrophy-1;
Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors
Keywords: سیستم پروتئازوم Ubiquitin; Ovarian cancer; Bortezomib; Mifepristone; Chloroquine; ER stress; Autophagic flux; mRNA translation; Unfolded protein response; Ubiquitin proteasome system;
Polymerase delta-interacting protein 2 regulates collagen accumulation via activation of the Akt/mTOR pathway in vascular smooth muscle cells
Keywords: سیستم پروتئازوم Ubiquitin; Akt; protein kinase B; Atg; autophagy-related gene; ECM; extracellular matrix; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; eIF4E; eukaryotic translation initiation factor 4E; Hsc70; heat shock cognate protein 70; LC3B; microtubule-associate
Phenazine derivatives cause proteotoxicity and stress in C. elegans
Keywords: سیستم پروتئازوم Ubiquitin; PD; Parkinson's disease; HD; Huntington's disease; PCA; phenazine-1-carboxylic acid; PCN; pyocyanin; 1-HP; 1-hydroxyphenazine; NAC; N-acetyl cysteine; UPS; ubiquitin proteasome system; UPR; unfolded protein response; Phenazines; C. elegans; ER stress; α-
Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells
Keywords: سیستم پروتئازوم Ubiquitin; PD; Parkinson's disease; GD; Gaucher disease; GCase; glucocerebrosidase; Sap C; saposin C; PSAP; prosaposin; LIMP-2; lysosomal integral membrane 2; ER; endoplasmic reticulum; TFEB; transcription factor EB; GSK3; glycogen synthase kinase 3; UPS; ubiquitin
Quality control mechanisms in cellular and systemic DNA damage responses
Keywords: سیستم پروتئازوم Ubiquitin; DNA damage; Ageing; Ubiquitin proteasome system; DNA repair; Progeroid syndromes; Genome stability; ARF; adenosine diphosphate ribosylation factor; AT; ataxia telangiectasia; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; BER; base excis
Characterizing the effect of Bortezomib on Rift Valley Fever Virus multiplication
Keywords: سیستم پروتئازوم Ubiquitin; Rift Valley Fever Virus; Ubiquitin proteasome system; NSs; SAP30; mSin3A; IFN-β;
pVHL interacts with Ceramide kinase like (CERKL) protein and ubiquitinates it for oxygen dependent proteasomal degradation
Keywords: سیستم پروتئازوم Ubiquitin; pVHL; the Von Hippel-Lindau tumor suppressor protein; ECV complex; elongin B/C-Cul2-VHL protein complex; PHD1-3; prolyl hydroxylase domain proteins 1-3; UPS; ubiquitin proteasome system; HIFs; hypoxia inducible factors; ROS; reactive oxygen species;
Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing
Keywords: سیستم پروتئازوم Ubiquitin; AAD; active adenylation domain; 4-PBA; 4-phenylbutyric acid; 6-OHDA; 6-hydroxydopamine; ABCG5/8; ATP-binding cassette sub-family G member 5/8; AD; Alzheimer's disease; AIB1; amplified in breast cancer 1; AIP4; atrophin-1 interacting protein 4; AMPA; α-