کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10022851 | 1589395 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhanced activation of circulating plasmacytoid dendritic cells in patients with Chronic Obstructive Pulmonary Disease and experimental smoking-induced emphysema
ترجمه فارسی عنوان
فعال سازی پیشرفته سلول های دندریتیک پلاسمایی گردش خون در بیماران مبتلا به بیماری ریوی مزمن و آمفیزم ناشی از تجربیات مصرف سیگار
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Plasmacytoid dendritic cells (pDCs) are key cells bridging the innate with adaptive immunity. However, the phenotypic characteristics of circulating pDCs and its role in smoking related-Chronic Obstructive Pulmonary Disease (COPD) remain largely unknown. The aim of this study was analyzed the phenotype of circulating pDCs and the expression of IFN-γ producing CD8+ T cells and IL-17-producing CD8+ T cells in patients with COPD by using multi-colour flow cytometry. The cytokine profiles in peripheral blood from all subjects were measured by ELISA. The influence of cigarette smoke on pDCs was evaluated in an experimental mouse model of emphysema. Circulating pDCs in patients with COPD and in mice exposed to cigarette smoke expressed high levels of co-stimulatory molecules CD40 or CD86 accompanied by exaggerated IFN-γ producing CD8+ T cells and IL-17-producing CD8+ T cells. In vitro, cigarette smoke directly promoted pDCs maturation and release of IFN-α, IL-6 and IL-12, subsequently inducing differentiation of IFN-γ producing CD8+ T cells and IL-17-producing CD8+ T cells from mouse naïve CD8+ T cells. These data suggested that circulating pDCs display an enhanced activation phenotype in patients with COPD and in experimental smoking mouse model of emphysema, which might contribute to exaggerated IFN-γ producing CD8+ T and IL-17-producing CD8+ T cell-mediated immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 195, October 2018, Pages 107-118
Journal: Clinical Immunology - Volume 195, October 2018, Pages 107-118
نویسندگان
Shi-lin Qiu, Liang-jian Kuang, Qi-ya Tang, Min-chao Duan, Jing Bai, Zhi-yi He, Jian-quan Zhang, Mei-hua Li, Jing-min Deng, Guang-nan Liu, Xiao-ning Zhong,