کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10106908 | 1613744 | 2018 | 55 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transient disruption of mouse home cage activities and assessment of orexin immunoreactivity following concussive- or blast-induced brain injury
ترجمه فارسی عنوان
اختلال موقت فعالیت های قفس درون ماوس و ارزیابی ایمونوئوراکتیوی اکسیدین در اثر آسیب مغزی ناشی از ضربه یا انفجار
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کلمات کلیدی
AmCHomogeneity of varianceSleep-wake disordersHOVBlast-induced traumatic brain injurybTBIkilopascalskPaTBSTNeurotraumamTBICCIPSISWDsHRPpost-injuryDABIgGEDSABS3,3′-diaminobenzidine - 3،3'-diaminobenzidineBSA - BSACOV - THETraumatic brain injury - آسیب تروماتیک مغزMild traumatic brain injury - آسیب مغزی آسیبدیده خفیفbovine serum albumin - آلبومین سرم گاوOrexin - اورکسینimmunoglobulin - ایمونوگلوبولینanalyses of variance - تجزیه و تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceConcussion - تکان مغزیexcessive daytime sleepiness - خواب آلودگی بیش از حد در طول روزRoom temperature - دمای اتاقLight emitting diode - دیود ساطع نورLED - رهبریCbi - سیبیCognition - شناختCoefficient of Variation - ضریب تغییرactivity - فعالیتCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیMouse - موشOpen field - میدان بازMicroglia - میکروگلیاهاHorseradish peroxidase - پراکسیداز هوررادیشcontrolled cortical impact - کنترل قشر مغزی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
The employment of explosive weaponry in modern warfare exposes populations to shock wave-induced and impact-related brain injuries. Among the most common clinical complaints resulting from traumatic brain injury (TBI) are sleep-wake disturbances. The current study assessed the acute effects of mild concussive brain injury (CBI) and mild blast wave-induced brain injury (BTBI) on mouse behavior and orexin-A expression. Male C57BL/6J mice were exposed to CBI, BTBI, or sham procedures. Injured animals and their shams were further divided into the following subgroups: 24-h survival in standard group (SG) housing, 72-h survival in SG housing, and 72-h survival in Any-Maze cages (AMc). AMc enabled continuous monitoring of home cage activities. BTBI caused significant but transient decreases in wheel running and ingestive behaviors 24â¯h post-injury (PI), while CBI transiently decreased running and water intake. BTBI resulted in general hypoactivity in the open field (OF) at both PI time points for SG-housed animals. In contrast, CBI did not cause hypoactivity. Mice subjected to CBI traveled more in the center of the OF at both time points PI, suggesting that CBI caused reduced anxiety in mice. Increased activity in the center of the OF was also seen at 24â¯h PI after BTBI. CBI treatment caused increased CD11b immunostaining. However, neither injury was accompanied by an alteration in the number of orexin-A hypothalamic neurons. Taken together, shock wave exposure and concussive injury transiently reduced mouse activities, but some differences between the two injuries were seen.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1700, 1 December 2018, Pages 138-151
Journal: Brain Research - Volume 1700, 1 December 2018, Pages 138-151
نویسندگان
Patricia A. Vu, Laura B. Tucker, Jiong Liu, Eileen H. McNamara, Thanhlong Tran, Amanda H. Fu, Yeonho Kim, Joseph T. McCabe,