کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10128066 | 1645123 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rheological characterization of new thermosensitive hydrogels formed by chitosan, glycerophosphate, and phosphorylated β-cyclodextrin
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A novel thermosensitive hydrogel consisting of phosphorylated β-cyclodextrin (βCD-PH), β-cyclodextrin (βCD) and chitosan was prepared by embedding βCD and βCD-PH, into the well-studied chitosan/αβ-glycerophosphate system (CS/αβGP). The relevance of this work is the use of βCD-PH to partially substitute αβGP as the gelling agent. The role of βCD and βCD-PH on the rheological properties of hydrogels, gelation time, and gelation temperature were investigated. The gelation time for all the samples (CS/αβGP, CS/αβGP/βCD, and CS/αβGP/βCD-PH) was less than a minute at 37â°C, which is suitable for biomedical applications. The gelation temperature for hydrogel CS/αβGP/βCD-PH increased linearly with the addition of βCD-PH within the interval 31.8-37.3â°C, at ratios CS:βCD-PH of 1:0.5, 1:1, 1:1.5 and 1:2 (w/w). The hydrogel thus obtained has potential applications in dual drug delivery (hydrophilic and hydrophobic).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 201, 1 December 2018, Pages 471-481
Journal: Carbohydrate Polymers - Volume 201, 1 December 2018, Pages 471-481
نویسندگان
Carlos Alberto RamÃrez Barragán, Emma Rebeca MacÃas Balleza, Lorena GarcÃa-Uriostegui, Jesús Angel Andrade Ortega, Guillermo TorÃz, Ezequiel Delgado,