کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10143364 | 1646163 | 2019 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
MS resulted in increased stress resilience, increased exploration and an overall anxiolytic behavioural phenotype in male Cdh13+/+ and Cdh13+/â mice. Cdh13 deficiency, however, obliterated most of the effects caused by early-life stress, with Cdh13â/â mice exhibiting delayed habituation, no reduction of anxiety-like behaviour and decreased fear extinction. Our behavioural findings indicate a role of CDH13 in the programming of and adaptation to early-life stress. Finally, our transcriptomic data support the view of CDH13 as a neuroprotective factor as well as a mediator in cell-cell interactions, with an impact on synaptic plasticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 89, 8 March 2019, Pages 158-168
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 89, 8 March 2019, Pages 158-168
نویسندگان
Dominik P. Kiser, Sandy Popp, Angelika G. Schmitt-Böhrer, Tatyana Strekalova, Daniel L. van den Hove, Klaus-Peter Lesch, Olga Rivero,