کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10143894 1646226 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effects of mitochondria-associated long noncoding RNAs in cancer mitochondria: New players in an old arena
ترجمه فارسی عنوان
اثرات موادی غیرکدنی طولانی مدت مرتبط با میتوکندری در میتوکندری سرطان: بازیکنان جدید در عرصه سابق
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی
LncRNAs, as new players in the old battle against cancer, are significant components of gene regulatory networks. Mitochondria-associated lncRNAs have newly been discovered to work in concert with transcription factors and epigenetic regulators to modulate mitochondrial gene expression and mitochondrial function. Many mitochondria-associated lncRNAs regulate mitochondrial biosynthesis, bioenergetics, apoptosis and possibly govern the cross-talk of mitochondria with nuclei. The complexity of mitochondria-associated lncRNAs is now just starting to envisage. In this review, we collected available evidence that reinforces the importance of mitochondria-associated lncRNA in cancer metabolism, apoptosis, and cell senescence. For the non-exhaustive list of mitochondria-associated lncRNAs, we identified 18 lncRNAs in total (mitochondria-encoded lncRNAs or nuclei encoded mitochondria function associated lncRNAs) as emerging new players in cancer mitochondrial function. As lncRNAs exhibit cancer-type-specific expression patterns, they are attractive targets for selective therapeutic interventions. Manipulation of their function may thus represent a valuable strategy for future cancer treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 131, November 2018, Pages 76-82
نویسندگان
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