کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10150419 | 1662997 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of drug loading capacity and release characteristics of PEDOT/naproxen system: Effect of doping ions
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
Conducting polymers are versatile and robust materials that have recently become attractive as controlled drug delivery systems. Possessing ion exchangeable properties, they can serve as carriers for numerous biologically active species, showing particular applicability in neural tissue engineering and regional chemotherapy. In the pursuit of the design of the most effective controlled drug delivery system, we aimed to compare the performance of the conducting polymer-based matrix as a function of doping anion, using chloride, perchlorate and dodecyl sulfate, respectively, as the primary dopants. Due to their different ion radius and mobility, selected ions were found to provide substantial changes into polymer characteristics, having strong effects into the uptake and release of a model drug, naproxen sodium salt. PEDOT/ClO4 matrix, particularly, was found to possess superior properties providing highest mass of the formed polymer (103.45â¯Â±â¯10.09â¯Î¼gâ¯cmâ2), charge storage capacity (44.9â¯mCâ¯cmâ2) and ion exchange capacity (0.122â¯Â±â¯0.003â¯Î¼molâ¯cmâ2), leading also to the highest amounts of loaded (0.024â¯Â±â¯0.002â¯Î¼molâ¯cmâ2) and released (from 0.71â¯Â±â¯0.10â¯Î¼gâ¯cmâ2 to 1.61â¯Â±â¯0.59â¯Î¼gâ¯cmâ2) drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Electrochimica Acta - Volume 289, 1 November 2018, Pages 218-227
Journal: Electrochimica Acta - Volume 289, 1 November 2018, Pages 218-227
نویسندگان
Katarzyna Krukiewicz, Aleksandra Kruk, Roman Turczyn,