کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10150419 1662997 2018 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of drug loading capacity and release characteristics of PEDOT/naproxen system: Effect of doping ions
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Evaluation of drug loading capacity and release characteristics of PEDOT/naproxen system: Effect of doping ions
چکیده انگلیسی
Conducting polymers are versatile and robust materials that have recently become attractive as controlled drug delivery systems. Possessing ion exchangeable properties, they can serve as carriers for numerous biologically active species, showing particular applicability in neural tissue engineering and regional chemotherapy. In the pursuit of the design of the most effective controlled drug delivery system, we aimed to compare the performance of the conducting polymer-based matrix as a function of doping anion, using chloride, perchlorate and dodecyl sulfate, respectively, as the primary dopants. Due to their different ion radius and mobility, selected ions were found to provide substantial changes into polymer characteristics, having strong effects into the uptake and release of a model drug, naproxen sodium salt. PEDOT/ClO4 matrix, particularly, was found to possess superior properties providing highest mass of the formed polymer (103.45 ± 10.09 μg cm−2), charge storage capacity (44.9 mC cm−2) and ion exchange capacity (0.122 ± 0.003 μmol cm−2), leading also to the highest amounts of loaded (0.024 ± 0.002 μmol cm−2) and released (from 0.71 ± 0.10 μg cm−2 to 1.61 ± 0.59 μg cm−2) drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Electrochimica Acta - Volume 289, 1 November 2018, Pages 218-227
نویسندگان
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