Identification of anti-Gram-negative bacteria agents targeting the interaction between ribosomal proteins L12 and L10

In this study, a yeast two-hybrid system was established to detect the interaction between L12 and L10 proteins from E. coli. With this system, we identified two compounds IMB-84 and IMB-87 that block L12-L10 interaction and show bactericidal activity against E. coli.123