کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10158367 | 1666522 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
miRNA-1246 suppresses acute lung injury-induced inflammation and apoptosis via the NF-κB and Wnt/β-catenin signal pathways
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Acute lung injury (ALI) is the common and complicated inflammatory lung disease. MicroRNAs (miRNA) have emerged as novel gene regulatory molecules which play a crucial role in multiple complicated diseases, including ALI. In this study, we aims to identify potential regulatory functions of miRNA-1246 in lipopolysaccharide (LPS)-induced ALI. In ALI mice, miRNA-1246 expression is effectively up-regulated, compared with the control group. miRNA-1246 overexpression effectively increases inflammation and apoptosis of in vitro ALI model. In contrast, miRNA-1246 knockdown effectively inhibits inflammation and cell apoptosis in vitro ALI model. Furthermore, up-regulation of miRNA-1246 significantly induces nuclear factor-kappa B (NF-κB) protein expression, and suppresses Wnt and β-catenin protein expression in vitro ALI model. Following the inhibition of NF-κB or Wnt/β-catenin signal using inhibitors, miRNA-1246 shows no significant effects on ALI-induced inflammation and apoptosis. Taken together, miRNA-1246 mediates ALI-induced lung inflammation and apoptosis via the NF-κB activation and Wnt/β-catenin suppression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 108, December 2018, Pages 783-791
Journal: Biomedicine & Pharmacotherapy - Volume 108, December 2018, Pages 783-791
نویسندگان
Tao Suo, Guo-zhong Chen, Yi Huang, Kao-chang Zhao, Tao Wang, Ke Hu,