کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10161947 | 1114307 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigation of Polycaprolactone Matrices for Intravaginal Delivery of Doxycycline
ترجمه فارسی عنوان
بررسی ماتریس های پلی کاپرولاکتون برای تحویل داخل وریدی دواسی سیکلین
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Polycaprolactone (PCL) matrices loaded with doxycycline were produced by rapidly cooling suspensions of the drug powder in PCL solution in acetone. Drug loadings of 5%, 10%, and 15% (w/w) of the PCL content were achieved. Exposure of doxycycline powder to matrix processing conditions in the absence of PCL revealed an endothermic peak at 65 °C with the main peak at 167 °C, suggesting solvatomorph formation. Rapid “burst release” of 24%-32% was measured within 24 h when matrices were immersed in simulated vaginal fluid (SVF) at 37 °C, because of the presence of drug at or close to the matrix surface, which is further confirmed by scanning electron microscopy. Gradual release of 66%-76% of the drug content occurred over the following 14 days. SVF containing doxycycline released from drug-loaded PCL matrices retained 81%-90% antimicrobial activity compared with the nonformulated drug. The concentrations of doxycycline predicted to be released into vaginal fluid from a PCL matrix in the form of an intravaginal ring would be sufficient to kill Neisseria gonorrhoea and many other pathogens. These results indicate that PCL may be a suitable polymer for controlled intravaginal delivery of doxycycline for the treatment of sexually transmitted infections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 12, December 2015, Pages 4217-4222
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 12, December 2015, Pages 4217-4222
نویسندگان
Meenakshi Pathak, Allan G.A. Coombes, Mark S. Turner, Cheryn Palmer, Dongjie Wang, Kathryn J. Steadman,