کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10161998 | 1114310 | 2015 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development and In Vitro Evaluation of Vitamin E-Enriched Nanoemulsion Vehicles Loaded with Genistein for Chemoprevention Against UVB-Induced Skin Damage
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کلمات کلیدی
Controlled release - انتشار کنترل شدهTocotrienol - توکوتیرنولPhysicochemical properties - خواص فیزیکی و شیمیاییSelf-emulsifying - خود امولسیونBiocompatibility - زیست سازگاریPhotoprotection - عکسبرداریIn vitro models - مدل های in vitroNanoemulsion - نانوامولسیون Skin reactivity - واکنش پذیری پوستCancer chemoprevention - پیشگیری شیمیایی سرطان
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
There is a great need for effective protection against cutaneous pathologies arising from chronic exposure to harmful solar UVB radiations. A promising pharmaceutical strategy to improve the efficacy of chemotherapeutic/preventative natural compounds (e.g., soy isoflavone Genistein, Gen) is to enhance their dermal delivery using nanoemulsion (NE) formulations. This report investigates the development of nanoemulsified tocotrienol(T3)-rich fraction of red palm oil (Tocomin® ), to yield an optimal NE delivery system for dermal photoprotection (z-average size < 150 nm, ζ-potential â â 30 mV, polydispersity index < 0.25). Physicochemical characterization and photostability studies indicate NE formulations utilizing surfactant mixture (Smix) of Solutol® HS-15 (SHS15) blended with vitamin E TPGS (TPGS) as cosurfactant was significantly superior to formulations that utilized Lutrol® F68 (LF68) as the cosurfactant. A ratio of 60:40 of SHS15-TPGS-NE was further identified as lead Tocomin® NE topical platform using in vitro pharmaceutical skin reactivity studies that assess cutaneous irritancy and cytotoxicity. Prototype Tocomin® NE loaded with the antiphotocarcinogenic molecule Gen (Gen-Tocomin® NE) showed slow-release profile in both liquid and cream forms. Gen-Tocomin® NE also showed excellent biocompatibility, and provided substantial UVB protection to cultured subcutaneous L929 fibroblasts, indicating the great potential of our Tocomin® NE warranting further prototype development as topical pharmaceutical platform for skin photoprotection applications. ® 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3510-3523, 2015
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 10, October 2015, Pages 3510-3523
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 10, October 2015, Pages 3510-3523
نویسندگان
Bill Brownlow, Vinay J. Nagaraj, Amy Nayel, Megha Joshi, Tamer Elbayoumi,