کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10162007 1114312 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantifying Dry Milling in Pharmaceutical Processing: A Review on Experimental and Modeling Approaches
ترجمه فارسی عنوان
چگالی دانه خشک در پردازش دارویی: بررسی روشهای تجربی و مدلسازی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی
Particle size reduction by mechanical means is an important unit operation in the pharmaceutical industry, used to improve flow, solubility, and in amorphization of drugs. It is usually achieved by the fracturing of particles under the action of applied energy. Despite being pervasive in the pharmaceutical field, it is one of the least understood processes owing to the complexity of material and process variables involved during milling. To comprehend the process, efforts should be focused on techniques that measure the particle size as well as the control the process. With the ongoing initiative of US FDA to encourage design in quality, the review is focused on some process analytical tools to characterize particle size distribution as well as process modeling tools to simulate particle size reduction. Additionally, an overview of some fundamental aspects related to milling is provided. To this end, the review is limited, mainly concentrating on some of experimental and modeling approaches used to quantify and understand the physics behind the process of dry milling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 8, August 2015, Pages 2401-2413
نویسندگان
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