کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162071 | 1114315 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Systematic Screening of Different Surface Modifiers for the Production of Physically Stable Nanosuspensions
ترجمه فارسی عنوان
غربالگری سیستماتیک اصلاح کننده سطحی مختلف برای تولید نانوساختارهای پایدار فیزیکی
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کلمات کلیدی
Wet ball milling - آسیاب توپ مرطوبParticle size - اندازه ذراتPolymers - بسپار یا پلیمر Physical stability - ثبات فیزیکیSurfactants - سورفکتانتها یا مواد فعال سطحیScreening - غربالگریcritical micelle concentration - غلظت متیل مهمNanosuspensions - نانوساختنSurface modifier - ویرایش سطحStabilization - پایدارسازی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
The role of a surface modifier is important in the formation of stable nanosuspensions. In this study, a simple and systematic screening method for selecting optimum surface modifiers was performed by utilizing a low-energy wet ball milling method. Nine surface modifiers from different classes with different stabilization mechanisms were applied on six different models of active pharmaceutical ingredients (API). Particle size analysis showed that at concentration five times higher than the critical micelle concentration, SDS and sodium cholate (anionic surfactant) showed the highest percent success to produce stable nanosuspensions with particle size smaller than 250Â nm. Similar findings were also shown by poloxamer 188 (nonionic surfactant) and hydroxypropylmethylcellulose E5 (polymeric stabilizer) at concentration 1% (w/v) and 0.8% (w/v), respectively. In addition, combinations of anionic surfactant and nonionic surfactant as well as combinations of anionic surfactant and polymeric stabilizer showed high percent success in the formation of stable nanosuspensions. In general, no correlation can be found between the physicochemical characteristics of the model API (molecular weight, melting point, log P, pKa, and crystallinity) with its feasibility to be nanosized. The concentration and the principle of stabilization of surface modifier determine the formation of stable nanosuspensions. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 3, March 2015, Pages 1128-1140
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 3, March 2015, Pages 1128-1140
نویسندگان
Maria L.A.D. Lestari, Rainer H. Müller, Jan P. Möschwitzer,