کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162087 | 1114316 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dropwise Additive Manufacturing of Pharmaceutical Products for Melt-Based Dosage Forms
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Dissolution - انحلال Polymers - بسپار یا پلیمر Oral drug delivery - تحویل داروی خوراکیProcess analytical technology - تکنولوژی تحلیلی فرایندProcessing - در حال پردازشSurfactants - سورفکتانتها یا مواد فعال سطحیDrug delivery systems - سیستم های تحویل داروSolid dosage form - فرم دوز جامدSolid dispersion - پراکندگی جامدQuality by design - کیفیت طراحی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The US Food and Drug Administration introduced the quality by design approach and process analytical technology guidance to encourage innovation and efficiency in pharmaceutical development, manufacturing, and quality assurance. As part of this renewed emphasis on the improvement of manufacturing, the pharmaceutical industry has begun to develop more efficient production processes with more intensive use of online measurement and sensing, real-time quality control, and process control tools. Here, we present dropwise additive manufacturing of pharmaceutical products (DAMPP) as an alternative to conventional pharmaceutical manufacturing methods. This mini-manufacturing process for the production of pharmaceuticals utilizes drop on demand printing technology for automated and controlled deposition of melt-based formulations onto edible substrates. The advantages of drop-on-demand technology, including reproducible production of small droplets, adjustable drop sizing, high placement accuracy, and flexible use of different formulations, enable production of individualized dosing even for low-dose and high-potency drugs. In this work, DAMPP is used to produce solid oral dosage forms from hot melts of an active pharmaceutical ingredient and a polymer. The dosage forms are analyzed to show the reproducibility of dosing and the dissolution behavior of different formulations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 5, May 2015, Pages 1641-1649
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 5, May 2015, Pages 1641-1649
نویسندگان
Elçn Içten, Arun Giridhar, Lynne S. Taylor, Zoltan K. Nagy, Gintaras V. Reklaitis,