کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162202 | 1114323 | 2015 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Scale Up of Pan Coating Process Using Quality by Design Principles
ترجمه فارسی عنوان
مقیاس فرایند پوشش پان با استفاده از کیفیت با اصول طراحی
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Scale up of pan coating process is of high importance to the pharmaceutical and food industry. The number of process variables and their interdependence in a pan coating process can make it a rather complex scale-up problem. This review discusses breaking down the coating process variables into three main categories: pan-related, spray-related, and thermodynamic-related factors. A review on how to scale up each of these factors is presented via two distinct strategies-“macroscopic” and “microscopic” scale-up. In a Quality by Design paradigm, where an increased process understanding is required, there is increased emphasis on “microscopic” scale-up, which by definition ensures a more reproducible process and thereby robust scale-up. This article also reviews the various existing and new modeling and process analytical technology tools that can provide additional information to facilitate a more fundamental understanding of the coating process. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3589-3611, 2015
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 11, November 2015, Pages 3589-3611
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 11, November 2015, Pages 3589-3611
نویسندگان
Anjali M. Agrawal, Preetanshu Pandey,