کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162397 | 1114328 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization and Release Studies of Liposomal Gels Containing Glutathione/Cyclodextrins Complexes Potentially Useful for Cutaneous Administration
ترجمه فارسی عنوان
توصیف و انتشار مطالعات ژلهای لیپوزومی که حاوی ترکیبات گلوتاتیون / سیکلوکودکسترین هستند، به طور بالقوه مفید برای تزریق پوستی
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
The aim of this work is to develop and characterize a formulation intended for the cutaneous administration of glutathione (γ-glutamylcysteinylglycine, GSH), potentially useful for cellular defense against UV-induced damage. For this purpose, liposomes containing GSH or GSH/cyclodextrins(CDs) inclusion complexes as well as liposomes dispersed within a hydrophilic gel, were evaluated. These formulations were designed in order to obtain a system combining the advantages of liposomes as vehicles for topical drug delivery with those of CDs as penetration enhancers. The studied CDs were the natural (β-CD) and chemically modified (i.e., HP-β-CD and CH3-β-CD) cyclodextrins. The prepared liposomes showed homogeneous size distribution, mean diameter in the range 622-1435 nm, small positive charge (+3.1 to +6.6 mV), and encapsulation efficiency of the peptide in the range 13.6%-23.7%. Release studies showed that the presence of the oligosaccharide may influence to some extent the amount of drug released, whereas stability studies clearly point out that the incorporation in a hydrophilic gel of 2-hydroxyethylcellulose insures a stable formulation maintaining unchanged the characteristics of liposomal vesicles. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:1246-1254, 2014
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 4, April 2014, Pages 1246-1254
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 4, April 2014, Pages 1246-1254
نویسندگان
Annalisa Cutrignelli, Angela Lopedota, Nunzio Denora, Valentino Laquintana, Serena Tongiani, Massimo Franco,