کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162456 | 1114330 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Infrared Thermography for Monitoring of Freeze-Drying Processes: Instrumental Developments and Preliminary Results
ترجمه فارسی عنوان
ترموگرافی مادون قرمز برای نظارت بر فرآیندهای خشک کردن خشک: تحولات ابزار و نتایج اولیه
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کلمات کلیدی
یخ خشک کردن، لیوفیلیزاسیون، دوربین مادون قرمز، ترموگرافی، اسپکتروسکوپ مادون قرمز، رزولوشن فضایی، آب در جامدات سرم انسان، در حال پردازش،
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Coupling an infrared (IR) camera to a freeze dryer for on-line monitoring of freeze-drying cycles is described for the first time. Normally, product temperature is measured using a few invasive Pt-100 probes, resulting in poor spatial resolution. To overcome this, an IR camera was placed on a process-scale freeze dryer. Imaging took place every 120 s through a Germanium window comprising 30,000 measurement points obtained contact-free from â40°C to 25°C. Results are presented for an empty system, bulk drying of cheese slurry, and drying of 1 mL human serum in 150 vials. During freezing of the empty system, differences of more than 5°C were measured on the shelf. Adding a tray to the empty system, a difference of more than 8°C was observed. These temperature differences probably cause different ice structures affecting the drying speed during sublimation. A temperature difference of maximum 13°C was observed in bulk mode during sublimation. When drying in vials, differences of more than 10°C were observed. Gradually, the large temperature differences disappeared during secondary drying and products were transformed into uniformly dry cakes. The experimental data show that the IR camera is a highly versatile on-line monitoring tool for different kinds of freeze-drying processes. © 2014 European Union 103:2088-2097, 2014
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 7, July 2014, Pages 2088-2097
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 7, July 2014, Pages 2088-2097
نویسندگان
HÃ¥kan Emteborg, Reinhard Zeleny, Jean Charoud-Got, Gustavo Martos, Jörg Lüddeke, Holger Schellin, Katharina Teipel,