کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10162524 1114333 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lisinopril Dihydrate: Single-Crystal X-Ray Structure and Physicochemical Characterization of Derived Solid Forms
ترجمه فارسی عنوان
لیزینوپریل دی هیدرات: ساختار کریستال تک کریستالی و خصوصیات فیزیکی و شیمیایی فرم های جامد ترکیب شده
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی
Screening for new solid forms of the antihypertensive lisinopril was performed by recrystallization of the commercial form, lisinopril dihydrate, from various solvents and by exposing the product of its dehydration to a series of vapors under controlled conditions. Modifications other than the dihydrate encountered in the study included new anhydrous and amorphous forms, with intrinsic dissolution rates significantly greater than that of the dihydrate. Further physicochemical characterization included constant and programmed temperature powder X-ray diffraction, differential scanning calorimetry, thermogravimetry, and Fourier transform infrared spectroscopy. In the course of this study, the single-crystal X-ray structure of lisinopril dihydrate, [a = 14.550(2), b = 5.8917(8), c = 14.238(2) Å, β = 112.832(3)° at T = 173(2) K , space group P21, Z = 2], was determined for the first time, revealing its double zwitterionic character in the solid state.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 10, October 2013, Pages 3596-3603
نویسندگان
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