کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10168093 | 1208251 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Heterogeneity in Skeletal Load Adaptation Points to a Role for Modeling in the Pathogenesis of Osteoporotic Fracture
ترجمه فارسی عنوان
عدم همبستگی در تعدیل بار اسکلت نقش مهمی در مدل سازی در پاتوژنز شکستگی استئوپروز دارد
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کلمات کلیدی
فمور، شکستگی بار مکانیکی، پس از یائسگی، فشار،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی
Genetic, environmental, or hormonal factors may cause heterogeneity in skeletal load response. Individuals with reduced sensitivity to load should require higher strains to generate an adaptive response, consequently have weaker bones and fracture more frequently. The purpose of our study was to determine if stresses (proportional to strains) at the femoral neck under equivalent loads were higher in women with a history of fractures compared with women without fractures. We studied postmenopausal women participating in the Canadian Multicentre Osteoporosis Study who had available hip structure analysis data from dual-energy X-ray absorptiometry scans (n = 2168). Women were categorized into 2 groups based on their number of self-reported fractures. We computed stress (megapascals) at the inferomedial margin of the femoral neck in a one-legged stance mode using a 2-dimensional engineering beam analysis. We used linear regression (SAS 9.3) to determine associations between stress, geometry parameters, and number of fractures. Postmenopausal women with 1 or more fractures had higher stress (2.6%), lower narrow neck bone mineral density (4.2%), cross-sectional area (3.9%), and section modulus (9.6%) than postmenopausal women without fractures (all p < 0.05). These findings provide evidence of heterogeneity in load response and suggest an important role for modeling in the pathogenesis of osteoporotic fracture.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Densitometry - Volume 17, Issue 1, January 2014, Pages 170-176
Journal: Journal of Clinical Densitometry - Volume 17, Issue 1, January 2014, Pages 170-176
نویسندگان
Celeste J. Hamilton, Sophie A. Jamal, Thomas J. Beck, Alia S. Khaled, Jonathan D. Adachi, Jacques P. Brown, Kenneth S. Davison, Canadian Multicentre Osteoporosis Study (CaMos) Research Group Canadian Multicentre Osteoporosis Study (CaMos) Research Group,