کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10224985 | 1701146 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oral malignant gastrointestinal neuroectodermal tumour with junctional component mimicking mucosal melanoma
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی قانونی
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چکیده انگلیسی
Malignant gastrointestinal neuroectodermal tumour (GNET) is a recently characterised rare and aggressive tumour that typically arises in association with the small intestine of adults. We present a novel case of this entity and expand the spectrum of its reported morphological features. The patient was a 5-year-old female, the youngest reported patient affected by the condition, and presented with extra-abdominal disease. The histopathological features included the presence of a junctional component of the palatal tumour, which mimicked mucosal melanoma, a feature that has not been previously reported in GNET. Whole genome and RNA sequencing was performed that demonstrated the EWSR1-ATF1 translocation characteristic of GNET. Knowledge of this entity and its features, together with careful morphological assessment supplemented by judicious immunohistochemical and molecular studies should enable the correct diagnosis to be established.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Volume 50, Issue 6, October 2018, Pages 648-653
Journal: Pathology - Volume 50, Issue 6, October 2018, Pages 648-653
نویسندگان
Benjamin M. Allanson, Martin A. Weber, Louise A. Jackett, Charles Chan, Loretta Lau, David S. Ziegler, Meera Warby, Chelsea Mayoh, Mark J. Cowley, Katherine M. Tucker, Georgina V. Long, Annabelle Maher, Antoinette Anazodo, Richard A. Scolyer,