کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10225556 1701188 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of maternal exposure to terror attacks during pregnancy and the risk of schizophrenia in the offspring: A population-based study
ترجمه فارسی عنوان
ارتباط مادران با قرار گرفتن در معرض حملات تروریستی در دوران بارداری و خطر اسکیزوفرنی در پسران: یک مطالعه مبتنی بر جمعیت
کلمات کلیدی
فشار، ریشه های جنین، اپیدمیولوژی، قبل از تولد، ترور، جنون جوانی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی
This study tested the hypothesis that maternal exposure to terror attacks during pregnancy is associated with the risk of schizophrenia in the offspring. A population-based study was conducted of Israeli children born between 1975 and 1995 and that were registered in the Ministry of Interior and followed up in the Ministry of Health from birth to 2015 for the risk of schizophrenia (N = 201,048). The association between maternal exposure to terror attacks during pregnancy and the risk of schizophrenia in the offspring was quantified with relative risks (RR) and their 95% confidence intervals (CI) fitting Cox regression models unadjusted and adjusted for confounders. Sensitivity analyses were performed to test the robustness of the results. The RR of schizophrenia in offspring of mothers exposed to terror attacks during pregnancy compared to offspring of mothers not exposed during pregnancy were estimated unadjusted (RR = 2.51, 95% CI, 1.33, 4.74) and adjusted (RR = 2.53, 95% CI, 1.63, 3.91). In the sensitivity analyses adjusted RRs were estimated using a sibling-based study design (2.85, 95% CI: 1.31-6.21) and propensity matching (2.45, 95% CI: 1.58-3.81). Maternal exposure to terror attacks during pregnancy was associated with an increased risk of schizophrenia in the offspring, possibly indicating a critical period of neurodevelopment that is sensitive to the stress of terror attacks and affected by epigenetic modifications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 199, September 2018, Pages 163-167
نویسندگان
, , , , , , ,