Biotransformation of valencene by cultured cells of Gynostemma pentaphyllum

It has been found that the suspension cultures of Gynostemma pentaphyllum convert valencene (1) into nootkatone (2) as the major product and nootkatol (3) as the minor product. Based on this finding, a further study was conducted to investigate the biotransformation of 1 by other cultured plant cells (Caragana chamlagu, Hibiscus cannabinus).