کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
69422 48763 2016 4 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Sulfation made easy: A new versatile donor for enzymatic sulfation by a bacterial arylsulfotransferase
ترجمه فارسی عنوان
سولفاتى شدن تسهیل می کند: یک کمک دهنده چندمنظوره جدید برای سولفات آنزیمی توسط arylsulfotransferase باکتری
کلمات کلیدی
Biocatalysis؛ سولفاتى شدن؛ روش مصنوعی؛ ترکیبات فنل؛ آریل سولفات ترانسفراز
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
چکیده انگلیسی


• A novel sulfate donor for the enzymatic sulfation of phenolic compounds is reported.
• This donor replaces the commonly used rather toxic P-nitrophenyl sulfate.
• Higher yields are obtained and purification of the sulfated compounds is simple.

An efficient and versatile donor for the sulfation by a bacterial arylsulfotransferase of various phenolic acceptor molecules is reported. Most studies in the past used toxic p-nitrophenyl sulfate as a sulfate donor for sulfation by this enzyme. However both the donor and p-nitrophenol are difficult to remove from the sulfated products. This new donor N-hydroxysuccinimide sulfate is easy to synthesize and has the advantage that at pH values above 7 it hydrolyzes to N-hydroxysuccinimide which is a safe compound and can easily be removed. As examples we demonstrated the formation of sulfated resveratrol and synthesized efficiently 3-sulfo-17-β-estradiol and bisphenol A bisulfate. It is likely that many other phenolic compounds are sulfated using this donor.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 129, July 2016, Pages 43–46
نویسندگان
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