کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10254153 | 160942 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ancestry analysis reveals a predominant Native American component with moderate European admixture in Bolivians
ترجمه فارسی عنوان
تجزیه و تحلیل اجباری نشان می دهد یک جزء بومی آمریکایی غالب با مخلوط متوسط اروپایی در بولیوی ها
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
چکیده انگلیسی
We have genotyped 46 Ancestry Informative Markers (AIMs) in two of the most populated areas in Bolivia, namely, La Paz (Andean region; n = 105), and Chuquisaca (Sub-Andean region; n = 73). Using different analytical tools, we inferred admixture proportions of these two American communities by comparing the genetic profiles with those publicly available from the CEPH (Centre d'Etude du Polymorphisme Humain) panel representing three main continental groups (Africa, Europe, and America). By way of simulations, we first evaluated the minimum sample size needed in order to obtain accurate estimates of ancestry proportions. The results indicated that sample sizes above 30 individuals could be large enough to estimate main continental ancestry proportions using the 46 AIMs panel. With the exception of a few individuals, the results also indicated that Bolivians showed a predominantly Native American ancestry with variable levels of European admixture. The proportions of ancestry were statistically different in La Paz and Chuquisaca: the Native American component was 86% and 77% (Mann-Whitney U-test: un-adjusted P-value = 2.1 Ã 10â5), while the European ancestry was 13% and 21% (Mann-Whitney U-test: un-adjusted P-value = 3.6 Ã 10â5), respectively. The African ancestry in Bolivians captured by the AIMs analyzed in the present study was below 2%. The inferred ancestry of Bolivians fits well with previous studies undertaken on haplotype data, indicating a major proportion of Native American lineages. The genetic differences observed in these two groups suggest that forensic genetic analysis should be better performed based on local databases built in the main Bolivian areas.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International: Genetics - Volume 7, Issue 5, September 2013, Pages 537-542
Journal: Forensic Science International: Genetics - Volume 7, Issue 5, September 2013, Pages 537-542
نویسندگان
Tanja Heinz, Vanesa Álvarez-Iglesias, Jacobo Pardo-Seco, Patricia Taboada-Echalar, Alberto Gómez-Carballa, Antonio Torres-Balanza, Omar Rocabado, Ángel Carracedo, Carlos Vullo, Antonio Salas,